Carboxymethylcellulose API Manufacturers
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Looking for Carboxymethylcellulose API 9000-11-7?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Carboxymethylcellulose. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Carboxymethylcellulose
- Synonyms:
- Carbose , Carboxymethyl cellulose , Carmellose , Carmelosa , Cellulose carboxymethyl ether , Cellulose gum , Cellulose, carboxymethyl ether , Thylose
- Cas Number:
- 9000-11-7
- DrugBank number:
- DB11059
- Unique Ingredient Identifier:
- 05JZI7B19X
General Description:
Carboxymethylcellulose, identified by CAS number 9000-11-7, is a notable compound with significant therapeutic applications. Carboxymethylcellulose is a cellulose derivative that consists of the cellulose backbone made up of glucopyranose monomers and their hydroxyl groups bound to carboxymethyl groups. It is added in food products as a viscosity modifier or thickener and emulsifier. It is also one of the most common viscous polymers used in artificial tears, and has shown to be effective in the treatment of aqueous tear-deficient dry eye symptoms and ocular surface staining . The viscous and mucoadhesive properties as well as its anionic charge allow prolonged retention time in the ocular surface . Sodium carboxymethylcellulose is the most commonly used salt.
Indications:
This drug is primarily indicated for: Indicated for the symptomatic relief of burning, irritation and discomfort of the eyes due to dryness or exposure to wind or sun. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Carboxymethylcellulose undergoes metabolic processing primarily in: No pharmacokinetic data available. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Carboxymethylcellulose are crucial for its therapeutic efficacy: No pharmacokinetic data available. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Carboxymethylcellulose is an important consideration for its dosing schedule: No pharmacokinetic data available. This determines the duration of action and helps in formulating effective dosing regimens.
Protein Binding:
Carboxymethylcellulose exhibits a strong affinity for binding with plasma proteins: No pharmacokinetic data available. This property plays a key role in the drug's pharmacokinetics and distribution within the body.
Route of Elimination:
The elimination of Carboxymethylcellulose from the body primarily occurs through: No pharmacokinetic data available. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Carboxymethylcellulose is distributed throughout the body with a volume of distribution of: No pharmacokinetic data available. This metric indicates how extensively the drug permeates into body tissues.
Clearance:
The clearance rate of Carboxymethylcellulose is a critical factor in determining its safe and effective dosage: No pharmacokinetic data available. It reflects the efficiency with which the drug is removed from the systemic circulation.
Pharmacodynamics:
Carboxymethylcellulose exerts its therapeutic effects through: In a randomized clinical study of patients with mild or moderate forms of eye dryness, ophthalmic treatment with sodium carboxymethylcellulose resulted in a diminished frequency of symptoms compared to the placebo group . Carboxymethylcellulose interacts with human corneal epithelial cells to facilitate corneal epithelial wound healing and attenuate eye irritation in a dose-dependent manner . It exhibits protective actions on the ocular surface in various applications; it mediates cytoprotective effects on the ocular surface when applied prior to contact lenses and reduces the incidence of epithelial defects during LASIK . The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Carboxymethylcellulose functions by: Carboxymethylcellulose binds to the surface of corneal epithelial cells via its glucopyranose subunits binding to glucose receptors GLUT-1 . The residence time of carboxymethylcellulose bound to corneal cells is approximately 2 hours as indicated by a short-term binding assay . Binding of carboxymethylcellulose to the matrix proteins stimulated corneal epithelial cell attachment, migration, and re-epithelialization of corneal wounds . This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Toxicity:
Categories:
Carboxymethylcellulose is categorized under the following therapeutic classes: Anorexigenic Agents & Respiratory and CNS Stimulants, Artificial Tears, Bulk-Forming Laxatives, Carbohydrates, Carboxymethylcellulose Sodium, Cellulose, Compounds used in a research, industrial, or household setting, EENT Drugs, Miscellaneous, Gastrointestinal Agents, Glucans, Laxatives, Polysaccharides. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Carboxymethylcellulose include:
- Melting Point: 300
Carboxymethylcellulose is a type of Emollients and protectives
Emollients and protectives are an essential category of pharmaceutical Active Pharmaceutical Ingredients (APIs) used in various topical formulations. These substances play a crucial role in protecting and moisturizing the skin, making them widely utilized in the pharmaceutical and cosmetic industries.
Emollients are substances that help restore and maintain the skin's natural moisture barrier, preventing water loss and promoting hydration. They act by forming a thin film on the skin's surface, reducing transepidermal water loss (TEWL) and improving the skin's texture and elasticity. Common emollients include natural oils, such as jojoba oil, almond oil, and shea butter, as well as synthetic compounds like mineral oil and petrolatum.
Protectives, on the other hand, are API ingredients that shield the skin from harmful external factors, such as irritants, allergens, and environmental pollutants. They create a physical barrier that prevents the penetration of harmful substances into the skin. Protectives are often combined with emollients to provide a dual function of hydration and protection.
The applications of emollients and protectives are vast and encompass a wide range of pharmaceutical and cosmetic products. They are commonly found in moisturizers, creams, lotions, ointments, balms, and sunscreens. These APIs are especially beneficial for individuals with dry or sensitive skin, as they can soothe irritation, reduce redness, and alleviate discomfort.
In conclusion, emollients and protectives are vital categories of pharmaceutical APIs that provide hydration and protection to the skin. Their versatile applications make them crucial ingredients in a wide array of topical formulations, contributing to the overall health and well-being of the skin.
