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Pegvorhyaluronidase alfa
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Looking for Pegvorhyaluronidase alfa API 1620390-06-8?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Pegvorhyaluronidase alfa. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Pegvorhyaluronidase alfa
- Synonyms:
- HUMAN HYALURONIDASE PH-20 (HYALURONOGLUCOSAMINIDASE PH-20, SPERM ADHESION MOLECULE 1, EC 3.2.1.35) PRECURSOR-(36-482)-PEPTIDE (MATURE (1-447)-PEPTIDE), PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, GLYCOFORM ALFA, SUBSTITUTED ON N6 OF AN AVERAGE OF 4 TO , PEGylated recombinant human hyaluronidase PH20 , POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-(3-CARBOXYPROPYL)-.OMEGA.-METHOXY-, AMIDE WITH HYALURONOGLUCOSAMINIDASE (HUMAN ISOENZYME PH20)
- Cas Number:
- 1620390-06-8
- DrugBank number:
- DB14912
- Unique Ingredient Identifier:
- P01I4980ZS
General Description:
Pegvorhyaluronidase alfa, identified by CAS number 1620390-06-8, is a notable compound with significant therapeutic applications. Pegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection).
Categories:
Pegvorhyaluronidase alfa is categorized under the following therapeutic classes: Carbon-Oxygen Lyases, Enzymes, Enzymes and Coenzymes, Glycoside Hydrolases, Hydrolases, Lyases, Polysaccharide-Lyases. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Pegvorhyaluronidase alfa is a type of Enzyme Replacements/modifiers
Enzyme replacements/modifiers are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various enzyme-related disorders. Enzymes play a vital role in the normal functioning of the body by catalyzing specific biochemical reactions. However, in certain medical conditions, the body may lack or produce dysfunctional enzymes, leading to serious health complications.
Enzyme replacement therapy (ERT) involves administering exogenous enzymes to compensate for the enzyme deficiency in patients. These enzymes are typically derived from natural sources or produced using recombinant DNA technology. By introducing these enzymes into the body, they can effectively substitute the missing or defective enzymes, thereby restoring normal metabolic processes.
On the other hand, enzyme modifiers are API substances that regulate the activity of specific enzymes within the body. These modifiers can either enhance or inhibit the enzyme's function, depending on the therapeutic objective. By modulating enzyme activity, these APIs can restore the balance of enzymatic reactions, leading to improved physiological outcomes.
Enzyme replacements/modifiers have shown remarkable success in treating various genetic disorders, such as Gaucher disease, Fabry disease, and lysosomal storage disorders. Additionally, they have demonstrated potential in managing enzyme deficiencies associated with rare diseases and certain types of cancer.
The development and production of enzyme replacements/modifiers involve rigorous research, formulation optimization, and adherence to stringent quality control measures. Pharmaceutical companies invest substantial resources in developing these APIs to ensure their safety, efficacy, and compliance with regulatory standards.
Overall, enzyme replacements/modifiers represent a vital therapeutic category in modern medicine, offering hope and improved quality of life for patients with enzyme-related disorders.
