Indomethacin | compare suppliers & send inquiries for free
Looking for Indomethacin 53-86-1?
Learn more about Indomethacin. Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole-3-acetic acid. The pharmacological effect of indometacin is not fully understood, however, it is thought to be mediated through potent and nonselective inhibition of the enzyme cyclooxygenase (COX), which is the main enzyme responsible for catalyzes the rate-limiting step in prostaglandin and thromboxane biosynthesis via the arachidonic acid (AA) pathway.
Indometacin was first discovered in 1963 and it was first approved for use in the USA by the Food and Drug Administration in 1965, 10 along with other acetic acid derivatives such as diclofenac and sulindac that were also developed during the 1960s. Since then, indometacin has been extensively studied in clinical trials as one of the most potent NSAIDs in blocking prostaglandin synthesis and was among the first NSAIDs to be used in the symptomatic treatment of migraine and for headaches that eventually became known as “indomethacin-responsive” headache disorders. Most commonly used in rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute shoulder pains, and acute gouty arthritis, indometacin is currently available as oral capsules as well as other methods of administration, including rectal and intravenous formulations. Intravenous indometacin is administered to close a hemodynamically significant patent ductus arteriosus, as indicated by clinical evidence, in premature infants.
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Indomethacin manufacturers | traders | suppliers
We have 11 companies offering Indomethacin from 5 different countries.
Get in contact with the supplier of your choice:
- Shandong Octagon Chemicals Limited from China
- Gland Pharma from India
- Fabbrica Italiana Sintetici (FIS) from Italy
- Shaoxing Hantai Pharma from China
- Macleods Pharma from India
- CSPC Ouyi Pharma from China
- Taicang Pharmaceutical Factory from China
- Sogo Pharmaceutical from Japan
- Lundbeck Pharma from Italy
- ACE Japan from Japan
- Quimdis from France
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