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Afamelanotide
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Produced in:
Established in: 2011
MOQ: 1 g
Employees: 10+
Fast Response and Good Communication
Willingness To Start From Small
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Looking for Afamelanotide API 75921-69-6?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Afamelanotide. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Afamelanotide
- Synonyms:
- Melanotan 1 , MT-I
- Cas Number:
- 75921-69-6
- DrugBank number:
- DB04931
- Unique Ingredient Identifier:
- QW68W3J66U
About Afamelanotide
What can you use it for? Afamelanotide is a first-in-class, synthetic, 13-amino acid peptide analogue of the endogenous alpha melanocyte-stimulating hormone (α-MSH). It differs structurally from its endogenous counterpart by only two amino acids - these structural differences improve biological efficacy by imparting a greater affinity for its target and a longer biological half-life Afamelanotide is currently the only approved drug therapy used in the management of erythropoietic protoporphyria, having received approval in the EU in December 20147 and subsequent FDA approval in October 2019. Despite its relatively recent approval, afamelanotide has been available for use as an orphan drug in both the US and EU since 2008.
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Afamelanotide is a type of Melatonin agonists
Melatonin agonists are a class of pharmaceutical active pharmaceutical ingredients (APIs) that interact with melatonin receptors in the body. Melatonin is a hormone naturally produced by the pineal gland in the brain and is involved in regulating the sleep-wake cycle.
Melatonin agonists mimic the effects of melatonin by binding to melatonin receptors in the brain. By activating these receptors, they help regulate circadian rhythms and promote sleep. These APIs are commonly used in the treatment of sleep disorders, such as insomnia and jet lag.
One widely used melatonin agonist is ramelteon, which selectively binds to melatonin receptors MT1 and MT2. It has a high affinity for these receptors, making it effective in promoting sleep without causing significant side effects.
Melatonin agonists offer several advantages over traditional sleep medications. They have a favorable safety profile, with minimal risk of dependence or abuse. Unlike sedative-hypnotic drugs, melatonin agonists do not suppress natural sleep architecture and are less likely to cause daytime drowsiness.
In addition to their sleep-promoting properties, melatonin agonists have shown potential in the treatment of other conditions. Research suggests they may be beneficial in managing circadian rhythm disorders, such as shift work disorder and delayed sleep phase syndrome.
Overall, melatonin agonists are a promising class of pharmaceutical APIs for improving sleep quality and addressing sleep-related disorders. Their unique mechanism of action and favorable safety profile make them a valuable option for individuals seeking effective and reliable sleep aids.
Afamelanotide manufacturers | traders | suppliers
We have 2 companies offering Afamelanotide produced in 2 different countries.
Get in contact with the supplier of your choice:
- Shandong Octagon Chemicals Limited from China, product country of origin China
- Corden Pharma from Germany, product country of origin Belgium
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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