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More information about this product: Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression 2781. Furthermore, in 2009 the US FDA approved milnacipran for the additional indication of treating fibromyalgia 26, although other regional regulatory authorities like the EMA, among others, have not yet approved the agent for such treatment, citing lack of robust evidence of efficacy, insufficient demonstration of maintenance of effect, and other concerns 278. Nevertheless, milnacipran demonstrates a somewhat unique characteristic among SNRIs to elicit a relatively balanced reuptake inhibition of both serotonin and noradrenaline, with a somewhat increased preference for noradrenaline reuptake inhibition - which is potentially a point of interest given the plausible proposal that noradrenaline plays an important role in the mitigation of pain signals in the descending inhibitory pain pathways in the brain and spinal cord 14. Moreover, recent research has shown that the levorotatory enantiomer of milnacipran, levomilnacipran, may have the capacity to inhibit the activity of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), which has investigationally been associated with β-amyloid plaque formation - making the agent a possible course of treatment for Alzheimer's disease.
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Milnacipran manufacturers | traders | suppliers
We have 17 companies offering Milnacipran from 5 different countries.
Get in contact with the supplier of your choice:
- Apister life science pvt ltd from India
- Lupin from India
- Centaur Pharma from India
- Mylan from India
- Dr. Reddy's from India
- Glenmark Pharma from India
- Hetero Labs from India
- Dishman Pharmaceuticals and Chemicals from India
- Macleods Pharma from India
- MSN Pharma from India
- Pierre Fabre Medi. from France
- ACE Japan from Japan
- Unichem Labs. from India
- Sumitomo Chemical from Japan
- Cosma from Italy
- Raks Pharma from India
- Derivados Quimicos from Spain
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