- Raw materials
- Analgesics
- Non-opioid analgesics
- Salicylamide
Filters
Custom request?
Type
Production region
Qualifications
Country of origin
Salicylamide API Manufacturers & Suppliers
5 verified results
Commercial-scale Suppliers
Employees: 455+
All certificates
Employees: 50+
All certificates
All certificates
All certificates
All certificates
Total market transparency
Supplier trade data access
Buyer / supplier flow comparison
Salicylamide | CAS No: 65-45-2 | GMP-certified suppliers
A medication that provides non-narcotic analgesic and anti-inflammatory effects for mild to moderate pain and fever, commonly used in combination analgesic formulations.
Therapeutic categories
Product Snapshot
- Salicylamide is available in multiple formulation types including oral tablets and capsules, topical ointments and sprays, ophthalmic preparations, inhalation liquids, and liquid dosage forms such as elixirs and syrups
- Its primary therapeutic applications include pain relief, anti-inflammatory effects, and topical treatment of localized conditions
- The product is approved for commercial use and distribution in the US market
Clinical Overview
Pharmacologically, salicylamide functions as a non-steroidal anti-inflammatory agent with analgesic properties. It acts primarily through inhibition of cyclooxygenase (COX) enzymes, leading to decreased synthesis of prostaglandins that mediate inflammation and pain. Unlike selective COX-2 inhibitors, salicylamide’s mechanism is consistent with non-selective NSAIDs affecting both COX-1 and COX-2 isoenzymes, which contributes to its antirheumatic and sensory nerve modulatory effects.
Although specific clinical indications for salicylamide alone are not extensively documented, it is commonly used adjunctively in multi-ingredient analgesic preparations. Its pharmacodynamic profile categorizes it within analgesics that do not exert narcotic effects, making it a viable option for symptomatic treatment of pain and febrile conditions without central nervous system depression.
Absorption, distribution, metabolism, and excretion (ADME) data for salicylamide are limited in public literature. However, as an amide analog of salicylic acid, it is expected to exhibit similar metabolic pathways involving hepatic conjugation and renal elimination. Safety considerations include its classification among agents capable of inducing nephrotoxicity and potential disruption of electrolyte balance, such as hyperkalemia. These factors warrant caution in patients with renal impairment or cardiovascular conditions.
Notable usage contexts include its role in combination analgesic products widely available in retail settings, often under generic or regional brand names. Because of its inclusion in multi-component formulations, quality control parameters for salicylamide API procurement should emphasize assay purity, absence of impurities related to degradation or synthesis, and compliance with pharmacopeial specifications. Ensuring consistent batch-to-batch quality is essential to maintain safety and therapeutic efficacy in final dosage forms.
Identification & chemistry
| Generic name | Salicylamide |
|---|---|
| Molecule type | Small molecule |
| CAS | 65-45-2 |
| UNII | EM8BM710ZC |
| DrugBank ID | DB08797 |
Formulation & handling
- Salicylamide is a small molecule suitable for oral, topical, ophthalmic, and respiratory (inhalation) formulations.
- It exhibits moderate water solubility and lipophilicity (LogP 1.17), supporting diverse delivery forms including solids and liquids.
- Formulation stability should consider its phenolic structure, which may be prone to oxidation under certain conditions.
Regulatory status
| Lifecycle | The API's key patents have expired in the US, allowing for generic competition and increased market availability; as a result, the product is in a mature phase with established use and multiple generic alternatives. |
|---|
| Markets | US |
|---|
Supply Chain
| Supply chain summary | The supply landscape for Salicylamide includes multiple originator companies producing branded products primarily in the US market, as evidenced by various first aid kit formulations and specialized pain relief brands. These branded products are predominantly available in the US, with limited indication of presence in EU or other regions. Given the lack of detailed patent information, the existing broad availability of branded products suggests established market competition, potentially with generic alternatives already present or forthcoming. |
|---|
Safety
| Toxicity | Oral, rat LD50: 1890 mg/kg |
|---|
- Handle with appropriate personal protective equipment to avoid ingestion or inhalation
- Avoid contact with skin and eyes due to potential irritation
- Store in a well-ventilated area, as oral toxicity LD50 in rats is 1890 mg/kg
Salicylamide is a type of Non-opioid analgesics
Non-opioid analgesics are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that are widely used for the management of pain. Unlike opioids, which are known to have addictive properties, non-opioid analgesics offer pain relief without the risk of dependence or addiction.
These APIs work by inhibiting the production of prostaglandins, which are substances in the body that contribute to pain and inflammation. Non-opioid analgesics are typically available over-the-counter (OTC) and come in various forms such as tablets, capsules, creams, and gels.
One of the most common non-opioid analgesics is acetaminophen, which is highly effective in relieving mild to moderate pain. It is commonly used to alleviate headaches, toothaches, and musculoskeletal pain. Another popular non-opioid analgesic is non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen. These medications not only reduce pain but also have anti-inflammatory properties, making them particularly useful for conditions such as arthritis.
Non-opioid analgesics are generally well-tolerated but can have potential side effects, including gastrointestinal disturbances and, in rare cases, liver or kidney damage. It is important to follow recommended dosages and consult a healthcare professional if there are any concerns or underlying medical conditions.
In conclusion, non-opioid analgesics are a vital category of pharmaceutical APIs that offer effective pain relief without the risk of addiction. Their accessibility, diverse formulations, and relatively favorable safety profile make them a popular choice for individuals seeking relief from various types of pain.
Salicylamide (Non-opioid analgesics), classified under Analgesics
Analgesics are a category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that are commonly used to relieve pain. They are designed to alleviate discomfort by targeting the body's pain receptors or by reducing inflammation. Analgesics are widely utilized in the medical field to manage various types of pain, ranging from mild to severe.
One of the primary classes of analgesics is nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by inhibiting the production of prostaglandins, substances that contribute to pain and inflammation. This class includes well-known drugs like ibuprofen and naproxen. Another class of analgesics is opioids, which are derived from opium or synthetic compounds that mimic the effects of opium. Opioids act on the central nervous system to reduce pain perception and provide potent pain relief. Examples of opioids include morphine, codeine, and oxycodone.
Analgesics are available in various forms, such as tablets, capsules, creams, and injections, allowing for different routes of administration based on the patient's needs. They are commonly used to manage pain associated with conditions like arthritis, headaches, dental procedures, and post-operative recovery.
It is important to note that analgesics should be used under medical supervision, as improper use or overuse can lead to adverse effects, including gastrointestinal complications, addiction, and respiratory depression in the case of opioids. Therefore, it is crucial for healthcare professionals to assess each patient's individual needs and prescribe the appropriate analgesic and dosage.
In summary, analgesics are a vital category of pharmaceutical APIs used to alleviate pain by targeting pain receptors or reducing inflammation. With various classes and forms available, they provide valuable options for pain management when used responsibly and under medical guidance.
Salicylamide API manufacturers & distributors
Compare qualified Salicylamide API suppliers worldwide. We currently have 5 companies offering Salicylamide API, with manufacturing taking place in 4 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| API Corp. | Producer | Japan | Japan | CoA, JDMF | 11 products |
| Iwaki Seiyaku | Producer | Japan | Japan | CoA, JDMF | 21 products |
| JQC (Huayin) Pharmaceutic... | Producer | China | China | CoA | 8 products |
| Pharm Rx Chemical Corp | Distributor | United States | India | BSE/TSE, CoA, GMP, MSDS | 166 products |
| Polpharma | Producer | Poland | Poland | BSE/TSE, CoA, EDMF/ASMF, FDA, GMP, MSDS | 64 products |
When sending a request, specify which Salicylamide API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Salicylamide API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
