Request a quote
Request a quote
Global API sourcing simplified
We connect API buyers and suppliers worldwide with speed, trust, and full transparency.

Filters

Filters
Filter
Custom request?
Type
Production region
Qualifications
Show more
Country of origin

Choline alfoscerate API Manufacturers & Suppliers

2 verified results
Take control of your API sourcing
Submit a Special Inquiry and have Pharmaoffer activate verified suppliers.
Start a Special Inquiry Get full access

Commercial-scale Suppliers

China

Distributor
Produced in  China
|

Employees: 50+

|
Audit Report: Currently Eurofins has no report for this supplier. Contact them to let them know you're interested!
Certifications: GMP
|
USDMF
|
MSDS
|
ISO9001
|
CoA

All certificates

GMP
USDMF
MSDS
ISO9001
CoA
Request a quote Request a quote

Italy

Producer
Produced in  Italy
|
Audit Report: Click here for more information on Eurofins audit reports
Certifications: GMP
|
CoA

All certificates

GMP
CoA
Request a quote Request a quote
Take control of your API sourcing
Submit a Special Inquiry and have Pharmaoffer activate verified suppliers.
Start a Special Inquiry Get full access
Get full market intelligence report
Get full market intelligence report
€399,-
All Choline alfoscerate data. Full access. Full negotiation power
Get my report Get my report
When insight is your advantage
Full data, full access, full negotiation power
Get full access Get full access
Total market transparency Total market transparency
|
Supplier trade data access Supplier trade data access
|
Buyer / supplier flow comparison Buyer / supplier flow comparison
Trusted by 30,000+ registered pharma professionals:
Reach multinationals, SMEs, compounding pharmacies & more!
Procaps
Pfizer
Reckitt
Sanofi
Blau
Abbvie

Choline alfoscerate | CAS No: 28319-77-9 | GMP-certified suppliers

A medication that serves as an investigational choline-based compound used in research exploring neurological function and membrane lipid support for development-stage therapeutic applications.

Therapeutic categories

AlcoholsBiological ProductsCarbohydratesGlycerophosphatesGlycerophospholipidsLecithins
Generic name
Choline alfoscerate
Molecule type
small molecule
CAS number
28319-77-9
DrugBank ID
DB04660
Approval status
Experimental drug, Investigational drug
ATC code
N07AX02

Product Snapshot

  • Choline alfoscerate is available as oral capsules and parenteral solutions for intravenous or intramuscular administration
  • It is primarily developed for cognitive and neurodegenerative disorder–related applications
  • It is classified as investigational with no major regulatory approvals in the US or EU

Clinical Overview

Choline alfoscerate (CAS 28319-77-9) is a glycerophosphocholine derivative belonging to the broader class of phosphatidylcholine-related lipids. It represents a choline-containing glycerophosphate in which fatty acid esterification occurs at the glycerol backbone. As a naturally occurring intermediate in phospholipid metabolism, it contributes to the structural and functional integrity of cell membranes. Experimental data indicate that compounds in this class can counteract destabilizing effects of urea on enzymes and macromolecules, consistent with established observations for glycerophosphocholines.

The clinical indication for choline alfoscerate is not specified in the provided dataset, and its regulatory status remains experimental or investigational. As such, no definitive therapeutic claims can be made. Research contexts have focused on its role as a metabolic precursor of choline, a substrate involved in acetylcholine biosynthesis and membrane phospholipid turnover, but a validated mechanism of action has not been established.

Pharmacodynamic characterization is limited. Based on its chemical class, it may participate in pathways related to membrane lipid homeostasis and cholinergic function, but the extent of these actions in humans is not defined. ADME parameters are also insufficiently characterized in the supplied data. General properties of glycerophosphocholine derivatives suggest potential hydrolysis to release choline, followed by typical choline absorption and metabolism, although specific kinetic values for this compound are not provided.

Safety and toxicity information are restricted due to its investigational status. No confirmed clinical safety profile, dose–response relationship, or organ-specific toxicity data are included in the referenced materials. Use in any setting should therefore rely on controlled research protocols.

Choline alfoscerate appears in various regional formulations, but brand names and marketed contexts are not specified in the data. For API procurement, sourcing should prioritize suppliers able to demonstrate identity and purity through validated analytical methods, with particular attention to phospholipid-related impurities and stability under typical storage conditions.

Identification & chemistry

Generic name Choline alfoscerate
Molecule type Small molecule
CAS 28319-77-9
UNII 60M22SGW66
DrugBank ID DB04660

Pharmacology

Targets
TargetOrganismActions
Ganglioside GM2 activatorHumans

Formulation & handling

  • Suitable for both oral solutions/capsules and parenteral solutions due to high aqueous solubility and solid-state stability of the glycerophosphocholine salt.
  • Highly hydrophilic (very low LogP) profile favors rapid dissolution in oral forms but may require stabilizers to limit hydrolysis in aqueous solutions.
  • For injectable formulations, aqueous stability and pH control are key considerations to prevent degradation of the phospholipid moiety.

Regulatory status

Choline alfoscerate is a type of Nootropics


Nootropics, belonging to the pharmaceutical API category, are cognitive enhancers that have gained significant popularity in recent years. These compounds, also known as "smart drugs" or "brain boosters" are designed to improve cognitive functions such as memory, focus, creativity, and overall mental performance.

Nootropics work by influencing neurotransmitters, enzymes, and receptors in the brain, enhancing communication between neurons. This results in improved synaptic plasticity, neuroprotection, and increased blood flow to the brain. Some common types of nootropics include racetams, cholinergics, and herbal supplements like ginkgo biloba and Bacopa monnieri.

The benefits of using nootropics are varied and can be of great interest to individuals seeking cognitive enhancement. Students, professionals, and individuals in demanding mental tasks often turn to nootropics to enhance their productivity and mental clarity. Additionally, nootropics are sometimes used by individuals looking to mitigate age-related cognitive decline.

It is important to note that while nootropics are generally considered safe, it is crucial to consult with a healthcare professional before starting any new supplement regimen. This ensures compatibility with existing medications and prevents potential adverse effects.

As the demand for cognitive enhancers continues to rise, the pharmaceutical industry is investing in research and development to create novel and more potent nootropic compounds. With ongoing advancements in understanding brain function, it is anticipated that nootropics will continue to evolve, offering improved cognitive benefits and expanding their potential applications in the future.

Choline alfoscerate API manufacturers & distributors

Compare qualified Choline alfoscerate API suppliers worldwide. We currently have 2 companies offering Choline alfoscerate API, with manufacturing taking place in 2 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.

SupplierTypeCountryProduct originCertificationsPortfolio
Producer
Italy Italy CoA, GMP18 products
Distributor
China China CoA, GMP, ISO9001, MSDS, USDMF762 products

When sending a request, specify which Choline alfoscerate API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).

Use the list above to find high-quality Choline alfoscerate API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.

We show synonyms and CAS numbers for Choline alfoscerate API to help you connect with the right supplier. However, a synonym or CAS number does not always mean it is exactly the same specification. Always confirm the final specs directly with the supplier before placing an order.

Frequently asked questions about Choline alfoscerate API


Sourcing

Which documents are typically required when sourcing Choline alfoscerate API?
Request the core API documentation set: CoA (3 companies), GMP (2 companies), MSDS (2 companies), ISO9001 (2 companies), FDA (1 company). Confirm versions and validity dates match the destination market to avoid delays in qualification.
Which manufacturers are known to produce Choline alfoscerate API?
Known or reported manufacturers for Choline alfoscerate: Xi'an Tian Guangyuan Biotech Co.,Ltd, Sinoway industrial Co.,Ltd. Evaluate their GMP history, scale, and regional coverage before requesting dossiers or allocating demand.
How can I request quotes for Choline alfoscerate API from GMP suppliers?
Submit quote requests through the supplier listings with your specs and required documents (specifications, target volume, delivery timeline, and destination). Providing consistent details upfront speeds comparable offers and clarifies technical feasibility.
Is a GMP audit report available for Choline alfoscerate manufacturers?
Audit reports may be requested for Choline alfoscerate: 1 GMP audit report available. Confirm the scope and recency of any audit before relying on it for qualification decisions.
How many suppliers offer Choline alfoscerate API on Pharmaoffer?
Reported supplier count for Choline alfoscerate: 3 verified suppliers. Filter listings by certifications, regions, and delivery options to match your qualification plan.
Which countries are known to manufacture Choline alfoscerate API?
Production countries reported for Choline alfoscerate: China (2 producers), Italy (1 producer). Knowing the manufacturing geography helps anticipate logistics lead times and import compliance needs.
Which certifications do suppliers of Choline alfoscerate usually hold?
Common certifications for Choline alfoscerate suppliers: CoA (3 companies), GMP (2 companies), MSDS (2 companies), ISO9001 (2 companies), FDA (1 company). Always verify issuing authorities and expiry dates when reviewing audit packages.

Technical

What is Choline alfoscerate (CAS 28319-77-9) used for?
Choline alfoscerate is used in research settings as a glycerophosphocholine derivative that functions as a metabolic precursor of choline. Studies investigate its potential to influence acetylcholine pathways and membrane lipid metabolism, but no confirmed clinical indication has been established. Its use is therefore limited to controlled experimental contexts.
Which therapeutic class does Choline alfoscerate fall into?
Choline alfoscerate belongs to the following therapeutic categories: Alcohols, Biological Products, Carbohydrates, Glycerophosphates, Glycerophospholipids. This positioning helps teams compare alternative APIs, anticipate pharmacology expectations, and align early research priorities.
What should someone know about the safety or toxicity profile of Choline alfoscerate?
Safety data for Choline alfoscerate are limited because it remains investigational. The provided information includes no confirmed clinical safety profile, dose–response data, or organ‑specific toxicity findings. Any use should occur within controlled research settings where monitoring and risk management can be ensured.
What are important formulation and handling considerations for Choline alfoscerate as an API?
Choline alfoscerate is highly water‑soluble and generally suitable for oral solutions, capsules, and aqueous parenteral formulations. Its hydrophilic nature supports rapid dissolution in oral products but may require stabilizers to limit hydrolysis in solution. For injectable use, controlling pH and maintaining aqueous stability are important to prevent degradation of the phospholipid component. Proper handling should focus on minimizing conditions that promote hydrolysis during manufacturing and storage.
Is Choline alfoscerate a small molecule?
Choline alfoscerate is classified as a small molecule. That classification shapes process design, impurity profiling, and analytical control strategies.
Are there special stability concerns for oral Choline alfoscerate?
Oral Choline alfoscerate is generally stable in solid forms such as capsules, where its glycerophosphocholine salt shows good solid‑state stability. In aqueous oral solutions, its high hydrophilicity increases the risk of hydrolysis, so stabilizers or careful formulation may be needed to limit degradation. pH control can also help maintain stability in liquid preparations.

Pharmaoffer

How does Pharmaoffer’s Smart Sourcing Service help with Choline alfoscerate procurement?
Pharmaoffer's Smart Sourcing Service coordinates compliant suppliers, documentation, and competitive quotes for Choline alfoscerate. It centralizes outreach, follow-ups, and document validation to shorten procurement timelines.
Is Choline alfoscerate included in the PRO Data Insights coverage?
PRO Data Insights coverage for Choline alfoscerate: 57 verified transactions across 14 suppliers and 13 buyers worldwide. Use the dataset to benchmark suppliers and monitor regulatory activity where available.
Where can I access the API market report for Choline alfoscerate?
Market report availability for Choline alfoscerate: Report Available. The report highlights demand trends, pricing drivers, and supplier landscape insights for procurement planning.