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Etofenamate | CAS No: 30544-47-9 | GMP-certified suppliers
A medication that provides localized analgesic and anti-inflammatory effects for the management of musculoskeletal and joint pain through topical application.
Therapeutic categories
Product Snapshot
- Etofenamate is available in multiple formulation types including topical creams, sprays, gels, patches, and injectable solutions
- It is primarily indicated for anti-inflammatory and analgesic applications
- Etofenamate currently holds experimental status and is not approved by major regulatory agencies such as the FDA or EMA
Clinical Overview
The clinical application of etofenamate focuses on its analgesic and anti-inflammatory effects, particularly for conditions associated with musculo-skeletal discomfort. Although detailed pharmacodynamic and mechanism of action data are not provided, NSAIDs like etofenamate generally exert therapeutic effects by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins that mediate inflammation and pain. Etofenamate is classified among non-selective COX inhibitors, impacting both COX-1 and COX-2 isoenzymes, which explains its anti-inflammatory properties and potential for gastrointestinal and renal adverse effects.
Pharmacokinetic parameters, including absorption, distribution, metabolism, and excretion (ADME), are not detailed in the available data. However, topical formulations are commonly utilized, aiming to deliver the active compound locally to affected tissues while minimizing systemic exposure.
Safety considerations with etofenamate align with the typical NSAID profile. These include risks of nephrotoxicity, gastrointestinal irritation, and potential cardiovascular effects such as hypertension and hyperkalemia. Caution is advised when used in populations vulnerable to these adverse events.
Currently, etofenamate is considered experimental in terms of formal regulatory approval status. It is found in topical products formulated for joint and muscular pain relief, often incorporated to provide localized analgesic and anti-inflammatory effects.
From an API sourcing perspective, strict adherence to quality standards is essential due to etofenamate’s chemical classification and its pharmacological activity. Procurement should ensure compliance with relevant pharmacopeial specifications and verification of purity, impurities, and stability profiles to support safe formulation development and regulatory submissions.
Identification & chemistry
| Generic name | Etofenamate |
|---|---|
| Molecule type | Small molecule |
| CAS | 30544-47-9 |
| UNII | KZF0XM66JC |
| DrugBank ID | DB08984 |
Formulation & handling
- Etofenamate is a small molecule with low water solubility and high lipophilicity (LogP 4.86), suitable for topical and intramuscular formulations.
- Available in topical creams, gels, patches, and intramuscular injections, requiring considerations for formulation stability and solubilization.
- Sensitive formulation handling is necessary to maintain stability in both aqueous and lipid-based delivery systems due to its ester functional group.
Regulatory status
Etofenamate is a type of NSAIDs
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are a widely used subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs). These medications are commonly prescribed for their analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties. NSAIDs work by inhibiting the production of certain enzymes called cyclooxygenases (COX), which play a crucial role in the synthesis of prostaglandins, substances that contribute to pain, inflammation, and fever.
These pharmaceutical APIs are available in various formulations, including tablets, capsules, creams, and gels, making them convenient for different administration routes. Some popular examples of NSAIDs include aspirin, ibuprofen, naproxen, and diclofenac.
NSAIDs are commonly used to treat a wide range of conditions such as arthritis, musculoskeletal injuries, dental pain, menstrual pain, and headaches. They are also effective in managing inflammatory conditions like rheumatoid arthritis and ankylosing spondylitis.
While NSAIDs are generally safe and effective when used as directed, they may have side effects. These can include gastrointestinal issues such as stomach ulcers or bleeding, cardiovascular risks, and kidney problems. Therefore, it is essential to follow the recommended dosage and consult with healthcare professionals to ensure proper and safe usage.
In conclusion, NSAIDs are a subcategory of pharmaceutical APIs that offer analgesic, anti-inflammatory, and antipyretic properties. Their versatility and effectiveness in treating various conditions make them widely prescribed medications. However, it is crucial to be aware of potential side effects and consult healthcare providers for appropriate usage.
Etofenamate (NSAIDs), classified under Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
Etofenamate API manufacturers & distributors
Compare qualified Etofenamate API suppliers worldwide. We currently have 3 companies offering Etofenamate API, with manufacturing taking place in 3 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| AXXO GmbH | Distributor | Germany | European Union | CEP, CoA, EDMF/ASMF, GMP, GDP, MSDS, USDMF | 243 products |
| Bayer | Producer | Germany | Unknown | CEP, CoA, GMP | 42 products |
| Duke Chem | Producer | Spain | Spain | CEP, CoA, GMP | 8 products |
When sending a request, specify which Etofenamate API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Etofenamate API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
