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- Zaltoprofen
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Zaltoprofen | CAS No: 74711-43-6 | GMP-certified suppliers
A medication that provides non-selective anti-inflammatory and analgesic effects for managing pain and inflammation, with considerations for metabolic interactions and safety monitoring.
Therapeutic categories
Product Snapshot
- Zaltoprofen is an oral small molecule formulation
- It is primarily investigated for its anti-inflammatory and analgesic properties
- The compound currently holds experimental status and lacks FDA or EMA approval
Clinical Overview
Pharmacologically, zaltoprofen functions as a non-selective NSAID, impacting the peripheral and sensory systems by inhibiting key inflammatory pathways. It is known to be a substrate for cytochrome P450 enzymes, particularly CYP2C9, implicating potential involvement in metabolic drug interactions. Additionally, it is metabolized by the enzyme UGT2B7. The compound’s metabolism and interaction with these enzyme systems necessitate consideration during formulation development and clinical use.
Although explicit data on its mechanism of action is not extensively documented, zaltoprofen’s classification suggests it inhibited prostaglandin synthesis, similar to other NSAIDs, thereby exerting anti-inflammatory and analgesic effects. However, it is categorized among non-selective NSAIDs, which typically have a risk profile including gastrointestinal irritation and nephrotoxic potential. The drug is also included in groups associated with effects on potassium balance and blood pressure, indicating that its use may require monitoring for hyperkalemia and hypertensive effects in susceptible patients.
Zaltoprofen is established in Japan under various brand names but remains experimental or limited in other global markets. For pharmaceutical formulation scientists and API sourcing managers, sourcing pharmaceutical-grade zaltoprofen requires attention to purity standards that ensure minimal impurities, including process-related substances attributable to its dibenzothiepin framework. Analytical verification of CYP substrate profiles and stability under various formulation conditions is advised to support safe and effective drug development and regulatory compliance.
Identification & chemistry
| Generic name | Zaltoprofen |
|---|---|
| Molecule type | Small molecule |
| CAS | 74711-43-6 |
| UNII | H8635NG3PY |
| DrugBank ID | DB06737 |
Formulation & handling
- Zaltoprofen is a small molecule suitable for oral formulation due to its low water solubility and moderate lipophilicity.
- Its chemical class suggests stability under standard solid handling conditions but may require protection from moisture.
- No peptide or biologic characteristics are present, minimizing concerns related to enzymatic degradation or immunogenicity.
Regulatory status
Zaltoprofen is a type of NSAIDs
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are a widely used subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs). These medications are commonly prescribed for their analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties. NSAIDs work by inhibiting the production of certain enzymes called cyclooxygenases (COX), which play a crucial role in the synthesis of prostaglandins, substances that contribute to pain, inflammation, and fever.
These pharmaceutical APIs are available in various formulations, including tablets, capsules, creams, and gels, making them convenient for different administration routes. Some popular examples of NSAIDs include aspirin, ibuprofen, naproxen, and diclofenac.
NSAIDs are commonly used to treat a wide range of conditions such as arthritis, musculoskeletal injuries, dental pain, menstrual pain, and headaches. They are also effective in managing inflammatory conditions like rheumatoid arthritis and ankylosing spondylitis.
While NSAIDs are generally safe and effective when used as directed, they may have side effects. These can include gastrointestinal issues such as stomach ulcers or bleeding, cardiovascular risks, and kidney problems. Therefore, it is essential to follow the recommended dosage and consult with healthcare professionals to ensure proper and safe usage.
In conclusion, NSAIDs are a subcategory of pharmaceutical APIs that offer analgesic, anti-inflammatory, and antipyretic properties. Their versatility and effectiveness in treating various conditions make them widely prescribed medications. However, it is crucial to be aware of potential side effects and consult healthcare providers for appropriate usage.
Zaltoprofen (NSAIDs), classified under Anti-inflammatory Agents
Anti-inflammatory agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat various inflammatory conditions. These agents play a vital role in alleviating pain, reducing swelling, and controlling inflammation in the body. They are widely employed in the management of diverse medical conditions, including arthritis, autoimmune disorders, asthma, and skin conditions like dermatitis.
Anti-inflammatory APIs primarily function by inhibiting the production of specific enzymes called cyclooxygenases (COX) and lipoxygenases (LOX). These enzymes are responsible for the synthesis of pro-inflammatory molecules known as prostaglandins and leukotrienes, respectively. By suppressing the activity of COX and LOX, anti-inflammatory agents effectively curtail the production of these inflammatory mediators, thereby mitigating inflammation.
Common examples of anti-inflammatory APIs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, aspirin, and naproxen. These agents exhibit analgesic, antipyretic, and anti-inflammatory properties. Another group of anti-inflammatory APIs includes corticosteroids, such as prednisone and dexamethasone, which are synthetic hormones that modulate the body's immune response to control inflammation.
In conclusion, anti-inflammatory agents are a vital category of pharmaceutical APIs widely used to manage inflammation-related disorders. They target enzymes involved in the synthesis of pro-inflammatory molecules, effectively reducing pain and swelling. NSAIDs and corticosteroids are commonly prescribed anti-inflammatory APIs due to their efficacy in controlling inflammation.
Zaltoprofen API manufacturers & distributors
Compare qualified Zaltoprofen API suppliers worldwide. We currently have 3 companies offering Zaltoprofen API, with manufacturing taking place in 2 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| Ipca Labs. | Producer | India | India | CoA, GMP, JDMF, WC | 69 products |
| Kolon Life Science | Producer | South Korea | South Korea | CoA, JDMF | 32 products |
| ZCL Chemicals | Producer | India | India | CoA, Other, FDA, ISO9001, KDMF, USDMF | 30 products |
When sending a request, specify which Zaltoprofen API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Zaltoprofen API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
