Naloxone API manufacturers
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Country of origin
Established in: 1885
Trusted for 140 years
Global distribution business with API manufacturing facilities
European company with presence in 3 continents
Established in: 2005
Portfolio of over 2,000 APIs
Precise quality control
End-to-end global regulatory support
MOQ: 1 kg
Taking advantage of our own Know-How and raw Material
Operating on GMP guidelines with the most recent technologies and equipment
Unrivalled prices and Flexible business models
Established in: 1963
World’s 1st exclusive API distributor
Portfolio of 600+ APIs
>250 clients in Europe
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Looking for Naloxone 465-65-6?
- Here you will find a list of producers, manufacturers and traders of Naloxone. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- EN 1530 Base , L-Naloxone , N-Allylnoroxymorphone , Nalossone , Naloxona , Naloxone , Naloxonum , Naloxone hydrochloride dihydrate
- Cas Number:
- DrugBank number:
- Unique Ingredient Identifier:
Some technical information about this product: Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other drugs bound to these receptors. When taken in large quantities, opioid medications such as morphine, hydromorphone, methadone, heroin, or fentanyl are capable of causing life-threatening symptoms such as respiratory depression, reduced heart rate, slurred speech, drowsiness, and constricted pupils. If untreated, this can progress to vomiting, absent pulse and breathing, loss of consciousness, and even death.
Naloxone is indicated for the rapid reversal of these symptoms of central nervous system depression in opioid overdose. It's important to note that naloxone only works on opioid receptors within the body, and is therefore not capable of reversing the effects of non-opioid medications such as stimulants like methamphetamine or cocaine, or benzodiazepines like lorazepam or diazepam. Also known as the brand name product Narcan, naloxone is currently available by intramuscular (IM) or subcutaneous (SubQ) injection, nasal spray, or intravenous (IV) infusion. Naloxone IM injections are commonly available in the form of "kits", which is ideal for making overdose treatment accessible and readily available for administration by minimally trained individuals within the community. Kits commonly include the supplies necessary to treat an overdose in a non-medical setting such as alcohol swabs, syringes, a rescue breathing mask, and instructions for use. Frequently also carried by medical and emergency personnel and at events known to be associated with heavy drug use like music festivals, naloxone kits are considered a key component of harm reduction strategies.
You can ask the supplier for more technical information about the product.
Naloxone is a type of Opioid antagonists
Opioid antagonists are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) that play a vital role in the management and treatment of opioid-related disorders. These powerful substances bind to opioid receptors in the brain, blocking the effects of opioids and reversing their potentially life-threatening effects.
Opioid antagonists work by competitively binding to opioid receptors, preventing opioids from attaching to these receptors and inhibiting their activity. This mechanism of action effectively counteracts the effects of opioids, including pain relief, sedation, and respiratory depression. By blocking the receptors, opioid antagonists can rapidly reverse the effects of opioid overdose, providing a vital emergency intervention.
One of the widely used opioid antagonists is naloxone, a highly effective and fast-acting medication. Naloxone is commonly administered in emergency settings, such as hospitals and ambulances, as well as by first responders and bystanders. Its rapid onset of action and short duration make it an essential tool for reversing opioid overdoses, potentially saving lives.
Opioid antagonists not only serve as a critical intervention for overdose cases but also have applications in the management of opioid addiction. By blocking the rewarding effects of opioids, these pharmaceutical APIs can help reduce cravings and prevent relapse in individuals undergoing opioid dependence treatment.
In conclusion, opioid antagonists are indispensable pharmaceutical APIs in combating the devastating effects of opioids. Their ability to bind to opioid receptors and counteract the effects of opioids makes them essential in both emergency situations and addiction treatment. Naloxone, among other opioid antagonists, stands as a crucial tool in saving lives and addressing the opioid crisis.
Naloxone manufacturers | traders | suppliers
We have 13 companies offering Naloxone from 6 different countries.
Get in contact with the supplier of your choice:
- Chr. Olesen Group from Denmark
- LGM Pharma from United States
- ENDOFAR Ilac from Turkey
- TIEFENBACHER API + Ingredients from Germany
- Siegfried from Germany
- Rusan Pharma from India
- Noramco from United States
- Macfarlan Smith from United Kingdom
- S.A.L.A.R.S. from Italy
- Sun Pharma from India
- Sanofi from France
- Resonance Labs. from India
- Mallinckrodt from United States
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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