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Produced in:
Established in: 1944
MOQ: -
Employees: 4,000
14 international API plant sites
Portfolio of 350+ APIs
Teva is among the world’s largest generic drug/API manufacturers
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Looking for Rosiglitazone API 122320-73-4?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Rosiglitazone. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Rosiglitazone
- Synonyms:
- Rosiglitazon , Rosiglitazona , Rosiglitazone , Rosiglitazonum
- Cas Number:
- 122320-73-4
- DrugBank number:
- DB00412
- Unique Ingredient Identifier:
- 05V02F2KDG
About Rosiglitazone
Here, you can find what Rosiglitazone is used for, in short. Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GSK as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ.
Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone. Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. This is the subject of a clinical trial currently underway.
More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.
Rosiglitazone is a type of Oral antidiabetics
Oral antidiabetics are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) used in the treatment of diabetes mellitus. These APIs are formulated into oral medications that help manage blood glucose levels in individuals with type 2 diabetes, the most common form of diabetes.
Oral antidiabetic APIs work by enhancing the body's ability to utilize insulin or by reducing the amount of glucose produced by the liver. These medications are taken orally, usually in the form of tablets or capsules, and are designed to be conveniently administered by patients themselves.
Within the oral antidiabetics category, there are several subcategories of APIs, each with distinct mechanisms of action and therapeutic benefits. These include biguanides, sulfonylureas, thiazolidinediones, meglitinides, DPP-4 inhibitors, SGLT-2 inhibitors, and alpha-glucosidase inhibitors.
Biguanides, such as metformin, decrease the amount of glucose produced by the liver and improve insulin sensitivity. Sulfonylureas, like glimepiride, stimulate the pancreas to release more insulin. Thiazolidinediones, such as pioglitazone, improve insulin sensitivity in peripheral tissues. Meglitinides, like repaglinide, stimulate insulin release by the pancreas. DPP-4 inhibitors, SGLT-2 inhibitors, and alpha-glucosidase inhibitors work by different mechanisms to control blood sugar levels.
The development and production of high-quality oral antidiabetic APIs involve rigorous quality control measures to ensure the safety and efficacy of the medications. Pharmaceutical companies and research institutions continuously strive to improve existing APIs and develop novel compounds to address the growing prevalence of diabetes worldwide.
Overall, oral antidiabetic APIs play a crucial role in managing diabetes, offering patients an effective and convenient means to control their blood glucose levels and mitigate the long-term complications associated with the disease.
Rosiglitazone manufacturers | traders | suppliers
We have 3 companies offering Rosiglitazone produced in 2 different countries.
Get in contact with the supplier of your choice:
- Chemsynlab from China, product country of origin China
- Teva API from Israel, product country of origin Unknown
- Zhejiang Chemsyn from China, product country of origin China
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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