Trimetazidine API Manufacturers

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Looking for Trimetazidine API 5011-34-7?

Description:
Here you will find a list of producers, manufacturers and distributors of Trimetazidine. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:
Trimetazidine 
Synonyms:
Trimetazidine dihydrochloride  
Cas Number:
5011-34-7 
DrugBank number:
DB09069 
Unique Ingredient Identifier:
N9A0A0R9S8

About Trimetazidine

Learn more about Trimetazidine. Trimetazidine is a drug for angina pectoris sold under the brand name Vastarel MR. Trimetazidine is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier (France). Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity, which results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation.

High fatty acid oxidation rates are detrimental during ischemia due to an inhibition of glucose oxidation leading to uncoupling of glycolysis and an increase in proton production, which has the potential to accelerate sodium and calcium overload in the heart, which leads to an exacerbation of ischemic injury and decreased cardiac efficiency during reperfusion.

You can ask the supplier for more technical information about the product.

Trimetazidine is a type of Other cardiac agents


The category of other cardiac agents in the pharmaceutical API (Active Pharmaceutical Ingredient) industry encompasses a diverse range of substances that play a crucial role in cardiovascular health. These agents are designed to target specific mechanisms within the cardiovascular system to either treat or manage various cardiac conditions. While they may not fall under the more well-known categories such as beta blockers or calcium channel blockers, they are equally significant in addressing cardiovascular disorders.

One prominent example of an API in this category is ivabradine, which acts as a selective inhibitor of the If current in the sinoatrial node. This unique mechanism allows it to reduce heart rate without affecting other cardiovascular parameters, making it particularly useful in managing stable angina or chronic heart failure.

Another notable API in this category is ranolazine, which exhibits a multi-modal mechanism of action involving inhibition of late sodium channels, resulting in improved myocardial ischemia and decreased angina episodes. It is commonly used in patients with chronic angina who have not adequately responded to other antianginal agents.

Furthermore, agents like trimetazidine, which possesses anti-ischemic and metabolic properties, and molsidomine, a nitric oxide donor, contribute to the category's diversity. They offer additional treatment options for angina and other related cardiac disorders.

The inclusion of these agents in the other cardiac agents category underscores the continuous efforts to develop novel pharmaceutical APIs that address specific cardiovascular conditions. Their distinct mechanisms of action provide healthcare professionals with a broader spectrum of therapeutic options for managing heart-related diseases.

C58


Trimetazidine manufacturers | traders | suppliers

We have 8 companies offering Trimetazidine produced in 2 different countries.

Get in contact with the supplier of your choice:

  • GVK Biosciences Pvt Ltd from India, product country of origin India
  • Maps Labs from India, product country of origin India
  • Aquatic Remedies Pvt Ltd from India, product country of origin India
  • JPN Pharma from India, product country of origin India
  • Themis Medicare from India, product country of origin India
  • USV from India, product country of origin India
  • Sharon Bio-Medicine from India, product country of origin India
  • Cipla from India, product country of origin Unknown

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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