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Etilevodopa | CAS No: 37178-37-3 | GMP-certified suppliers
A medication that supports investigational treatment of Parkinson’s disease by potentially improving motor symptoms through dopamine augmentation in the central nervous system.
Therapeutic categories
Primary indications
- Investigated for use/treatment in parkinson's disease
Product Snapshot
- Etilevodopa is an oral small molecule formulation
- It is primarily investigated for therapeutic use in Parkinson's disease management
- The compound remains in the investigational stage without current FDA or EMA approval
Clinical Overview
The compound has been investigated primarily for its potential application in the treatment of Parkinson's disease, a neurodegenerative disorder characterized by dopaminergic neuron loss in the central nervous system. While detailed pharmacodynamics and specific mechanism of action data are not fully established, etilevodopa is presumed to function as a prodrug or analogue of levodopa, aiming to augment central dopamine levels and thereby alleviate motor symptoms associated with dopamine deficiency.
Pharmacokinetic and metabolic profiles, including absorption, distribution, metabolism, and excretion (ADME) parameters, remain incompletely characterized in published literature. As a tyrosine derivative with catechol structural motifs, it is likely subject to enzymatic conversion pathways relevant to levodopa metabolism, including decarboxylation and methylation, but further data are required for precise characterization.
Safety and toxicity assessments have not been extensively documented, reflecting its investigational status and lack of regulatory approval for clinical use. Potential toxicity may parallel known risks associated with dopaminergic agents, including dyskinesia and neuropsychiatric effects, though direct evidence is lacking.
Etilevodopa does not currently have established brand names and remains an investigational compound within the anti-Parkinson drug category. Its use and development are primarily confined to research settings.
From an API sourcing perspective, procurement should emphasize synthetic purity and compliance with pharmacopeial standards applicable to amino acid derivatives. Analytical verification of chemical identity, residual solvents, and potential impurities is critical due to structural similarity with endogenous compounds and regulatory scrutiny typical for nervous system agents. Batch consistency and stability data are essential to support formulation and regulatory submissions.
Identification & chemistry
| Generic name | Etilevodopa |
|---|---|
| Molecule type | Small molecule |
| CAS | 37178-37-3 |
| UNII | 895X917GYE |
| DrugBank ID | DB06535 |
Formulation & handling
- Etilevodopa is a small molecule compound suitable for oral formulations due to its moderate water solubility and molecular weight.
- Handling should consider its investigational status and potential sensitivity to oxidation due to its tyrosine derivative structure.
- Stability and storage conditions need evaluation to prevent degradation, particularly under exposure to light or moisture.
Regulatory status
Etilevodopa is a type of Other substances
The pharmaceutical industry encompasses a diverse range of active pharmaceutical ingredients (APIs) that are used in the production of various medications. One category of APIs is known as other substances. This category includes substances that do not fall under the conventional classifications such as antibiotics, analgesics, or antihypertensives.
Other substances in pharmaceutical APIs consist of a broad array of chemical compounds with unique properties and applications. These substances play a crucial role in the formulation and development of specialized medications, catering to specific therapeutic needs. The category encompasses various substances like excipients, solvents, stabilizers, and pH adjusters.
Excipients are inert substances that aid in the manufacturing process and enhance the stability, bioavailability, and patient acceptability of pharmaceutical formulations. Solvents are used to dissolve other ingredients and facilitate their incorporation into the final product. Stabilizers ensure the integrity and shelf life of medications by preventing degradation or chemical changes. pH adjusters help maintain the desired pH level of a formulation, which can influence the drug's efficacy and stability.
Pharmaceutical manufacturers carefully select and incorporate specific other substances into their formulations, adhering to regulatory guidelines and quality standards. These substances undergo rigorous testing and evaluation to ensure their safety, efficacy, and compatibility with the desired pharmaceutical product. By employing other substances in API formulations, pharmaceutical companies can optimize drug delivery, improve patient compliance, and enhance therapeutic outcomes.
In summary, the other substances category of pharmaceutical APIs comprises a diverse range of chemicals, including excipients, solvents, stabilizers, and pH adjusters. These substances contribute to the formulation, stability, and performance of medications, enabling pharmaceutical manufacturers to develop specialized products that meet specific therapeutic requirements.
Etilevodopa API manufacturers & distributors
Compare qualified Etilevodopa API suppliers worldwide. We currently have 1 companies offering Etilevodopa API, with manufacturing taking place in 1 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| ChemCon GmbH | Producer | Germany | Germany | CoA, GMP, MSDS | 36 products |
When sending a request, specify which Etilevodopa API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Etilevodopa API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
