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Prezatide
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Looking for Prezatide API 49557-75-7?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Prezatide. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Prezatide
- Synonyms:
- GHK , Gly-His-Lys , Glycyl-L-histidyl-L-lysine , Glycylhistidyllysine , Growth-modulating peptide (human) , Liver cell growth factor , Tripeptide-1
- Cas Number:
- 49557-75-7
- DrugBank number:
- DB11296
- Unique Ingredient Identifier:
- 39TG2H631E
General Description:
Prezatide, identified by CAS number 49557-75-7, is a notable compound with significant therapeutic applications. Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions . Prezatide is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in chronic obstructive pulmonary disease and metastatic colon cancer are currently being investigated.
Indications:
This drug is primarily indicated for: Commonly used in cosmetic products for the skin and hair . Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Prezatide undergoes metabolic processing primarily in: Prezatide is broken down to histidyl-lysine which is likely further degraded to other metabolites of proteolysis . This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Prezatide are crucial for its therapeutic efficacy: Prezatide both free and in complex with copper can pass through the stratum corneum . Its absorption is pH dependent with the highest absorption occurring at physiological pH. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Prezatide is an important consideration for its dosing schedule: Prezatide is rapidly eliminated within minutes . This determines the duration of action and helps in formulating effective dosing regimens.
Pharmacodynamics:
Prezatide exerts its therapeutic effects through: Prezatide in complex with copper improve skin elasticity, density, and firmness, reduces fine lines and wrinkles, reduces photodamage, increases keratinocyte proliferation . Prezatide also displays anti-oxidant and angiogenic effects and appears to modulate tissue remodeling in injury. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Prezatide functions by: Prezatide in complex with copper increases the synthesis and deposition of type I collagen and glycosaminoglycan . It also increases the expression of matrix metalloproteinase-2 as well as tissue inhibitor of matrix metalloproteinases-1 and -2, suggesting that it plays a role in the modulation of tissue remodeling . It is thought that prezatide's antioxidant activity is due to its ability to supply copper for superoxide dismutase and its anti inflammatory ability due to the blockage the of iron (Fe2+) release during injury . Prezatide also increases angiogenesis to injury sites. The precise mechanisms of these effects are unknown. It is also unknown whether prezatide's effects are due to the action of the tripeptide itself or its ability to localize and transport copper . Prezatide is known to be bound by heparin and heparin sulfate. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Prezatide belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another, classified under the direct parent group Peptides. This compound is a part of the Organic compounds, falling under the Organic acids and derivatives superclass, and categorized within the Carboxylic acids and derivatives class, specifically within the Amino acids, peptides, and analogues subclass.
Categories:
Prezatide is categorized under the following therapeutic classes: Amino Acids, Peptides, and Proteins, Growth Substances, Peptides. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Prezatide is a type of Other substances
The pharmaceutical industry encompasses a diverse range of active pharmaceutical ingredients (APIs) that are used in the production of various medications. One category of APIs is known as other substances. This category includes substances that do not fall under the conventional classifications such as antibiotics, analgesics, or antihypertensives.
Other substances in pharmaceutical APIs consist of a broad array of chemical compounds with unique properties and applications. These substances play a crucial role in the formulation and development of specialized medications, catering to specific therapeutic needs. The category encompasses various substances like excipients, solvents, stabilizers, and pH adjusters.
Excipients are inert substances that aid in the manufacturing process and enhance the stability, bioavailability, and patient acceptability of pharmaceutical formulations. Solvents are used to dissolve other ingredients and facilitate their incorporation into the final product. Stabilizers ensure the integrity and shelf life of medications by preventing degradation or chemical changes. pH adjusters help maintain the desired pH level of a formulation, which can influence the drug's efficacy and stability.
Pharmaceutical manufacturers carefully select and incorporate specific other substances into their formulations, adhering to regulatory guidelines and quality standards. These substances undergo rigorous testing and evaluation to ensure their safety, efficacy, and compatibility with the desired pharmaceutical product. By employing other substances in API formulations, pharmaceutical companies can optimize drug delivery, improve patient compliance, and enhance therapeutic outcomes.
In summary, the other substances category of pharmaceutical APIs comprises a diverse range of chemicals, including excipients, solvents, stabilizers, and pH adjusters. These substances contribute to the formulation, stability, and performance of medications, enabling pharmaceutical manufacturers to develop specialized products that meet specific therapeutic requirements.
