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Tribenoside | CAS No: 10310-32-4 | GMP-certified suppliers
A medication that provides anti-inflammatory and vasoprotective effects for managing hemorrhoids, anal fissures, varicose veins, and vascular inflammation.
Therapeutic categories
Product Snapshot
- Tribenoside is available in multiple formulation types including oral capsules, rectal suppositories, and topical creams
- It is primarily utilized for its venotonic and anti-inflammatory properties
- The compound currently remains in the experimental approval stage with no authorized regulatory market approvals
Clinical Overview
The pharmacodynamics and detailed mechanism of action of tribenoside remain not fully elucidated in the public domain. However, it is classified pharmacologically as a capillary stabilizing agent and a vasoprotective, suggesting a role in enhancing capillary resistance and reducing capillary permeability. It is also categorized under anti-inflammatory agents and peripheral nervous system agents, which may indicate analgesic and anti-inflammatory activities relevant to inflammatory vascular conditions.
Key absorption, distribution, metabolism, and excretion (ADME) parameters for tribenoside have not been extensively characterized in the literature. Given its glycosidic structure, it may undergo hydrolytic metabolism potentially yielding aglycone derivatives, but comprehensive human pharmacokinetic data is lacking.
Safety and toxicity profiles for tribenoside are limited due to its experimental status and restricted clinical use. As with related compounds, monitoring for hypersensitivity or local irritation might be prudent when applied topically. No significant systemic toxicity data are available.
Tribenoside is included in drug categories for the treatment of hemorrhoids and anal fissures in topical formulations, as well as analgesics and antirheumatic agents. Notable brands or global approvals appear limited, reflecting its status as an experimental or regionally utilized agent.
For API procurement, attention should be paid to sourcing from manufacturers with established quality control that ensures purity and consistency. Given the compound’s glycosidic nature, storage conditions should prevent hydrolysis or degradation. Compliance with pharmacopeial or regulatory guidelines relevant to glycosidic APIs is recommended to assure batch-to-batch reproducibility and suitability for pharmaceutical formulation.
Identification & chemistry
| Generic name | Tribenoside |
|---|---|
| Molecule type | Small molecule |
| CAS | 10310-32-4 |
| UNII | Z7N0Y673NU |
| DrugBank ID | DB13227 |
Formulation & handling
- Tribenoside is a low water-soluble small molecule primarily formulated for oral and rectal administration.
- Its high LogP suggests considerations for lipid-based or solubility-enhancing formulation strategies to improve bioavailability.
- Forms include capsules, suppositories, and creams indicating versatility in delivery routes but no injectable formulations.
Regulatory status
Tribenoside is a type of Phlebotonics
Phlebotonics is a subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs) that are specifically designed to address venous disorders and promote healthy blood circulation. These APIs are used in the formulation of medications aimed at treating conditions such as chronic venous insufficiency, varicose veins, and hemorrhoids.
Phlebotonics work by strengthening the walls of blood vessels and improving their elasticity. They also help reduce inflammation and edema, which can be common symptoms of venous disorders. By enhancing venous tone and reducing blood stasis, phlebotonics help alleviate pain, swelling, and discomfort associated with these conditions.
The key active ingredients found in phlebotonics include substances like diosmin, hesperidin, rutosides, and troxerutin. These compounds exhibit venotonic properties, meaning they have a positive impact on venous tone and function. Phlebotonics are typically available in various dosage forms such as tablets, capsules, creams, and gels for convenient administration.
Medical professionals often recommend phlebotonics as an adjunctive treatment along with lifestyle modifications such as regular exercise, elevation of the legs, and compression therapy. These medications are generally well-tolerated and have a favorable safety profile.
In conclusion, phlebotonics are a specialized class of pharmaceutical APIs that play a crucial role in managing venous disorders. By improving venous tone, reducing inflammation, and enhancing blood circulation, these medications provide symptomatic relief and improve the overall quality of life for individuals with venous insufficiency, varicose veins, and hemorrhoids.
Tribenoside (Phlebotonics), classified under Others
The others category refers to pharmaceutical APIs that do not fall under specific classifications such as antibiotics, antivirals, analgesics, or cardiovascular drugs. These APIs are diverse in nature and serve various therapeutic purposes, making them a crucial component of pharmaceutical formulations.
Pharmaceutical companies develop APIs in the others category to address specific medical conditions or target novel biological pathways. This category includes APIs used in oncology, neurology, immunology, and other specialized areas of medicine. The APIs in this category are often designed to interact with specific molecular targets or receptors, providing targeted therapeutic effects.
The development of APIs in the others category requires extensive research and testing to ensure their efficacy, safety, and compliance with regulatory standards. Pharmaceutical manufacturers employ advanced techniques such as chemical synthesis, biotechnology, and genetic engineering to produce these APIs.
Due to the broad range of applications and therapeutic uses, APIs in the others category contribute significantly to the advancement of medical treatments. Pharmaceutical companies constantly strive to innovate and discover new APIs within this category to address unmet medical needs and improve patient outcomes.
In conclusion, the others category of pharmaceutical APIs encompasses a diverse range of active ingredients used in drug formulation. These APIs play a crucial role in developing innovative therapies across various therapeutic areas, contributing to advancements in healthcare and patient well-being.
Tribenoside API manufacturers & distributors
Compare qualified Tribenoside API suppliers worldwide. We currently have 3 companies offering Tribenoside API, with manufacturing taking place in 3 different countries. Use the table below to review supplier type, countries of origin, certifications, product portfolio and GMP audit availability.
| Supplier | Type | Country | Product origin | Certifications | Portfolio |
|---|---|---|---|---|---|
| ACS Dobfar | Producer | Italy | Italy | CoA, GMP | 36 products |
| Sandoz | Producer | Austria | Austria | CoA, GMP | 58 products |
| Zhuhai United Labs | Producer | China | China | CoA, GMP | 12 products |
When sending a request, specify which Tribenoside API quality you need: for example EP (Ph. Eur.), USP, JP, BP, or another pharmacopoeial standard, as well as the required grade (base, salt, micronised, specific purity, etc.).
Use the list above to find high-quality Tribenoside API suppliers. For example, you can select GMP, FDA or ISO certified suppliers. Visit our help page to learn more about sourcing APIs via Pharmaoffer.
