Pixantrone API Manufacturers
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Looking for Pixantrone API 144510-96-3?
- Description:
- Here you will find a list of producers, manufacturers and traders of Pixantrone. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Pixantrone
- Synonyms:
- PIX
- Cas Number:
- 144510-96-3
- DrugBank number:
- DB06193
- Unique Ingredient Identifier:
- F5SXN2KNMR
About Pixantrone
Why are professionals looking for Pixantrone? Pixantrone is an aza-anthracenedione and DNA intercalator which inhibits topoisomerase II. It is similar in structure to anthracyclines such as mitoxantrone, but exerts fewer toxic effects on cardiac tissue. The lower cardio-toxic effects of pixantrone may be explained, in part, by its redox inactivity. Pixantrone does not bind iron and promotes the formation of reactive oxygen species to a lesser degree than other anthracyclines.
It also inhibits doxorubicinol formation in human myocardium. As a result, it is believed to be less cardiotoxic while still exerting efficacy. Pixantrone was designed to treat relapsed or refractory aggressive non-Hodgkin's lymphoma(NHL) in patients who have failed two prior lines of therapy. For patients suffering from NHL, first line therapies consist of anthracycline containing multi-drug treatments which unfortunately are known to cause irreversible myocardial tissue damage. Patients refractory to treatment, or those who relapse, are discouraged from further anthracycline use due to cumulative cardiotoxicity. Pixantrone dimaleate, administered intravenously, was designed by Cell Therapeutics Incorporated as an alternative second line therapy in refractory or relapsed NHL. It is currently being tested in Phase III trials.
Do you want to buy this product? Send an inquiry to the listed suppliers that meets your quality requirements.
Pixantrone manufacturers | traders | suppliers
We have 1 companies offering Pixantrone produced in 1 different countries.
Get in contact with the supplier of your choice:
- LGM Pharma from United States, product country of origin World
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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