Amsacrine API Manufacturers

Looking for Amsacrine API 51264-14-3?

Description:

Here you will find a list of producers, manufacturers and distributors of Amsacrine. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Amsacrine 

Synonyms:

Acridinyl anisidide , Amsacrine , m-AMSA , mAMSA  

Cas Number:

51264-14-3 

DrugBank number:

DB00276 

Unique Ingredient Identifier:

00DPD30SOY

Amsacrine is a type of Topoisomerase I Inhibitors

Topoisomerase I inhibitors are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) used in cancer treatment. These inhibitors target the topoisomerase I enzyme, which plays a crucial role in DNA replication and transcription by relieving the torsional strain generated during these processes.

Topoisomerase I inhibitors work by binding to the topoisomerase I-DNA complex, preventing the resealing of DNA strands after they have been cleaved. This leads to the formation of DNA breaks, which subsequently result in the inhibition of DNA replication and transcription. By interfering with these vital cellular processes, topoisomerase I inhibitors impede the growth and proliferation of cancer cells.

Several topoisomerase I inhibitors have been developed and approved for clinical use. These include camptothecin derivatives such as irinotecan and topotecan, as well as non-camptothecin analogs like indenoisoquinolines. These inhibitors have shown efficacy in treating various types of cancer, including colorectal, ovarian, and lung cancers.

Despite their therapeutic potential, topoisomerase I inhibitors can also exhibit side effects, such as myelosuppression, diarrhea, and neutropenia. Therefore, their usage requires careful monitoring and management of adverse effects.

In conclusion, topoisomerase I inhibitors are a vital class of pharmaceutical APIs that hold promise in the treatment of cancer. Their ability to target and inhibit the topoisomerase I enzyme makes them effective in impeding cancer cell growth. Ongoing research aims to further optimize their efficacy and minimize their adverse effects, improving cancer treatment outcomes for patients.

Amsacrine (Topoisomerase I Inhibitors), classified under Anticancer drugs

Anticancer drugs belong to the pharmaceutical API (Active Pharmaceutical Ingredient) category designed specifically to combat cancer cells. These powerful medications play a crucial role in cancer treatment and are developed to target and destroy cancerous cells, preventing their growth and spread.

Anticancer drugs are classified based on their mode of action and can include various types such as chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, and hormonal therapy drugs. Chemotherapy drugs work by interfering with the cell division process, thereby inhibiting the growth of cancer cells. Targeted therapy drugs, on the other hand, are designed to attack specific molecules or genes involved in cancer growth, minimizing damage to healthy cells. Immunotherapy drugs stimulate the body's immune system to recognize and destroy cancer cells. Hormonal therapy drugs are used in cancers that are hormone-dependent, such as breast or prostate cancer, to block the hormones that fuel cancer cell growth.

These APIs are typically synthesized through complex chemical processes in state-of-the-art manufacturing facilities. Stringent quality control measures ensure the purity, potency, and safety of these drugs. Anticancer APIs undergo rigorous testing and adhere to stringent regulatory guidelines before being approved for clinical use.

Due to their critical role in cancer treatment, anticancer drugs are in high demand worldwide. Researchers and pharmaceutical companies continually strive to develop new and more effective APIs in this category to enhance treatment outcomes and minimize side effects. The ongoing advancements in the field of anticancer drug development offer hope for improved cancer therapies and better patient outcomes.

• LGM Pharma from United States, product country of origin World

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