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Granisetroni (Granisetron) API Manufacturers & Suppliers

Looking for Granisetron API 109889-09-0?

Description:

Here you will find a list of producers, manufacturers and distributors of Granisetron. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Granisetron 

Synonyms:

granisetronum , Granisetroni , Granisetron hydrochloride  

Cas Number:

109889-09-0 

DrugBank number:

DB00889 

Unique Ingredient Identifier:

WZG3J2MCOL

Granisetron is a type of 5HT3 antagonists

5HT3 antagonists are a subcategory of pharmaceutical APIs that play a crucial role in managing various conditions related to the serotonin neurotransmitter system. Serotonin, also known as 5-hydroxytryptamine (5HT), is a neurotransmitter that regulates various physiological functions, including mood, appetite, and gastrointestinal motility.

The 5HT3 antagonists work by selectively blocking the serotonin type 3 receptors in the central and peripheral nervous systems. By doing so, they inhibit the binding of serotonin to these receptors, thereby reducing its effects. This mechanism of action makes them effective in treating conditions such as chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome.

One of the commonly used 5HT3 antagonists is ondansetron, which is available in oral and injectable forms. It is widely prescribed to cancer patients undergoing chemotherapy to alleviate the distressing side effects of nausea and vomiting. Other notable 5HT3 antagonists include granisetron, palonosetron, and dolasetron.

These pharmaceutical APIs offer several advantages, including high selectivity for the 5HT3 receptors, rapid onset of action, and a favorable safety profile. They are typically well-tolerated by patients, with minimal adverse effects. However, healthcare professionals must consider individual patient factors and potential drug interactions when prescribing these medications.

In summary, 5HT3 antagonists are an important subcategory of pharmaceutical APIs that provide effective relief from nausea and vomiting associated with various medical conditions. Their targeted mechanism of action and favorable safety profile make them valuable tools in the management of these symptoms, benefiting patients and improving their overall quality of life.

Granisetron (5HT3 antagonists), classified under Antiemetics

Antiemetics are a crucial category of pharmaceutical Active Pharmaceutical Ingredients (APIs) used to alleviate and prevent nausea and vomiting, also known as emesis. They play a vital role in managing these distressing symptoms, which can be caused by various factors such as chemotherapy, postoperative recovery, motion sickness, or gastrointestinal disorders.

Antiemetics work by targeting specific pathways in the body that trigger emesis. One common mechanism involves blocking dopamine receptors in the brain, as dopamine plays a significant role in triggering the vomiting reflex. This class of antiemetics is known as dopamine antagonists. Another mechanism involves inhibiting serotonin receptors, which are associated with nausea and vomiting. These agents, called serotonin antagonists, effectively reduce these symptoms.

In addition to dopamine and serotonin antagonists, other types of antiemetics include neurokinin-1 receptor antagonists, antihistamines, and anticholinergics. Each of these classes acts on different pathways in the body to provide relief from nausea and vomiting.

Pharmaceutical companies manufacture antiemetic APIs in accordance with strict quality control guidelines and regulations. These APIs serve as the active ingredients in various formulations, such as tablets, capsules, injections, or suppositories, designed to deliver the desired therapeutic effects.

Overall, antiemetic APIs form an essential category in the pharmaceutical industry, addressing the significant need for effective management of nausea and vomiting. Their development and availability greatly contribute to enhancing patient comfort and quality of life during various medical treatments and conditions.

• Duchefa Farma B.V. from Netherlands, product country of origin China
• Shandong Octagon Chemicals Limited from China, product country of origin China
• Sinoway industrial Co.,Ltd from China, product country of origin China
• Fuan Pharmaceutical (Group) Co., LTD. from China, product country of origin China
• LGM Pharma from United States, product country of origin World
• Chongqing Carelife from China, product country of origin China
• Hubei Haosun Pharma from China, product country of origin China
• Zhejiang Hisun Pharma from China, product country of origin China
• Amino Chemicals from Malta, product country of origin Malta
• Dupont Nutrition from United States, product country of origin Norway
• Vihita Chem from India, product country of origin India
• Dr. Reddy's from India, product country of origin India
• Syn-tech Chem from Taiwan, product country of origin Taiwan
• Hubei Biocause from China, product country of origin China
• Natco Pharma from India, product country of origin India
• Hana Pharmaceutical from South Korea, product country of origin South Korea
• Cipla from India, product country of origin India
• Shaoxing Hantai Pharma from China, product country of origin China
• Sun Pharma from India, product country of origin India

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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