Antiemetics


Antiemetics are a crucial category of pharmaceutical Active Pharmaceutical Ingredients (APIs) used to alleviate and prevent nausea and vomiting, also known as emesis. They play a vital role in managing these distressing symptoms, which can be caused by various factors such as chemotherapy, postoperative recovery, motion sickness, or gastrointestinal disorders.

Antiemetics work by targeting specific pathways in the body that trigger emesis. One common mechanism involves blocking dopamine receptors in the brain, as dopamine plays a significant role in triggering the vomiting reflex. This class of antiemetics is known as dopamine antagonists. Another mechanism involves inhibiting serotonin receptors, which are associated with nausea and vomiting. These agents, called serotonin antagonists, effectively reduce these symptoms.

In addition to dopamine and serotonin antagonists, other types of antiemetics include neurokinin-1 receptor antagonists, antihistamines, and anticholinergics. Each of these classes acts on different pathways in the body to provide relief from nausea and vomiting.

Pharmaceutical companies manufacture antiemetic APIs in accordance with strict quality control guidelines and regulations. These APIs serve as the active ingredients in various formulations, such as tablets, capsules, injections, or suppositories, designed to deliver the desired therapeutic effects.

Overall, antiemetic APIs form an essential category in the pharmaceutical industry, addressing the significant need for effective management of nausea and vomiting. Their development and availability greatly contribute to enhancing patient comfort and quality of life during various medical treatments and conditions.

NameCAS numberCategoryAmount of suppliersAPI market price
Alosetron122852-42-05HT3 antagonistsView 5 Suppliers Average price per kg: $
Aprepitant170729-80-3AntiemeticsView 28 Suppliers Average price per kg: $
Azasetron123040-69-7AntiemeticsView 0 Suppliers Average price per kg: $
Cerium oxalate139-42-4AntiemeticsView 0 Suppliers Average price per kg: $
Chlorobutanol57-15-8AntiemeticsView 0 Suppliers Average price per kg: $
Cilansetron120635-74-75HT3 antagonistsView 1 Suppliers Average price per kg: $
Dexanabinol112924-45-5AntiemeticsView 0 Suppliers Average price per kg: $
Dimenhydrinate523-87-5AntiemeticsView 12 Suppliers Average price per kg: $
Diphenidol972-02-1AntiemeticsView 2 Suppliers Average price per kg: $
Dolasetron115956-12-2AntiemeticsView 5 Suppliers Average price per kg: $
Droperidol548-73-2AntiemeticsView 4 Suppliers Average price per kg: $
Fosaprepitant172673-20-0AntiemeticsView 14 Suppliers Average price per kg: $
Granisetron109889-09-05HT3 antagonistsView 33 Suppliers Average price per kg: $
MaropitantAntiemeticsView 3 Suppliers Average price per kg: $
Ondansetron99614-02-55HT3 antagonistsView 41 Suppliers Average price per kg: $
Ondansetron Compound A119812-29-25HT3 antagonistsView 1 Suppliers Average price per kg: $
Palonosetron135729-56-55HT3 antagonistsView 21 Suppliers Average price per kg: $
Ramosetron132036-88-55HT3 antagonistsView 3 Suppliers Average price per kg: $
Thiethylperazine1420-55-9AntiemeticsView 1 Suppliers Average price per kg: $
Trimethobenzamide138-56-7AntiemeticsView 2 Suppliers Average price per kg: $
Tropisetron89565-68-45HT3 antagonistsView 1 Suppliers Average price per kg: $
Vofopitant168266-90-8AntiemeticsView 0 Suppliers Average price per kg: $