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Ondansetron hydrochloride dihydrate (Ondansetron) API Manufacturers & Suppliers

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Description:

Here you will find a list of producers, manufacturers and distributors of Ondansetron. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Ondansetron 

Synonyms:

Zofran odt , Ondansetron hydrochloride dihydrate  

Cas Number:

99614-02-5 

DrugBank number:

DB00904 

Unique Ingredient Identifier:

4AF302ESOS

Ondansetron is a type of 5HT3 antagonists

5HT3 antagonists are a subcategory of pharmaceutical APIs that play a crucial role in managing various conditions related to the serotonin neurotransmitter system. Serotonin, also known as 5-hydroxytryptamine (5HT), is a neurotransmitter that regulates various physiological functions, including mood, appetite, and gastrointestinal motility.

The 5HT3 antagonists work by selectively blocking the serotonin type 3 receptors in the central and peripheral nervous systems. By doing so, they inhibit the binding of serotonin to these receptors, thereby reducing its effects. This mechanism of action makes them effective in treating conditions such as chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome.

One of the commonly used 5HT3 antagonists is ondansetron, which is available in oral and injectable forms. It is widely prescribed to cancer patients undergoing chemotherapy to alleviate the distressing side effects of nausea and vomiting. Other notable 5HT3 antagonists include granisetron, palonosetron, and dolasetron.

These pharmaceutical APIs offer several advantages, including high selectivity for the 5HT3 receptors, rapid onset of action, and a favorable safety profile. They are typically well-tolerated by patients, with minimal adverse effects. However, healthcare professionals must consider individual patient factors and potential drug interactions when prescribing these medications.

In summary, 5HT3 antagonists are an important subcategory of pharmaceutical APIs that provide effective relief from nausea and vomiting associated with various medical conditions. Their targeted mechanism of action and favorable safety profile make them valuable tools in the management of these symptoms, benefiting patients and improving their overall quality of life.

Ondansetron (5HT3 antagonists), classified under Antiemetics

Antiemetics are a crucial category of pharmaceutical Active Pharmaceutical Ingredients (APIs) used to alleviate and prevent nausea and vomiting, also known as emesis. They play a vital role in managing these distressing symptoms, which can be caused by various factors such as chemotherapy, postoperative recovery, motion sickness, or gastrointestinal disorders.

Antiemetics work by targeting specific pathways in the body that trigger emesis. One common mechanism involves blocking dopamine receptors in the brain, as dopamine plays a significant role in triggering the vomiting reflex. This class of antiemetics is known as dopamine antagonists. Another mechanism involves inhibiting serotonin receptors, which are associated with nausea and vomiting. These agents, called serotonin antagonists, effectively reduce these symptoms.

In addition to dopamine and serotonin antagonists, other types of antiemetics include neurokinin-1 receptor antagonists, antihistamines, and anticholinergics. Each of these classes acts on different pathways in the body to provide relief from nausea and vomiting.

Pharmaceutical companies manufacture antiemetic APIs in accordance with strict quality control guidelines and regulations. These APIs serve as the active ingredients in various formulations, such as tablets, capsules, injections, or suppositories, designed to deliver the desired therapeutic effects.

Overall, antiemetic APIs form an essential category in the pharmaceutical industry, addressing the significant need for effective management of nausea and vomiting. Their development and availability greatly contribute to enhancing patient comfort and quality of life during various medical treatments and conditions.

• Shandong Octagon Chemicals Limited from China, product country of origin China
• Fuan Pharmaceutical (Group) Co., LTD. from China, product country of origin China
• Gonane Pharma from India, product country of origin India
• SETV Global from India, product country of origin India
• Hikal from India, product country of origin India
• TIEFENBACHER API + Ingredients from Germany, product country of origin Unknown
• Unnati Pharmaceuticals Pvt Ltd from India, product country of origin India
• Gedeon Richter from Hungary, product country of origin Unknown
• Natco Pharma from India, product country of origin India
• Dr. Reddy's from India, product country of origin India
• Teva API from Israel, product country of origin Unknown
• Lorem from Spain, product country of origin Spain
• JPN Pharma from India, product country of origin India
• Sun Pharma from India, product country of origin India
• Ipca Labs. from India, product country of origin India
• Shaoxing Hantai Pharma from China, product country of origin China
• Cipla from India, product country of origin Unknown

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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