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Looking for Alglucosidase alfa 420784-05-0?

API | Excipient name:
Alglucosidase alfa 
Synonyms:
Acid maltase, Acid-alpha glucosidase, Aglucosidase alfa, Aglucosidase alpha, alpha-1, 4-glucosidase, Alpha-glucosidase, Lysosomal Alpha-Glucosidase  
Cas Number:
420784-05-0 
DrugBank number:
DB01272 
Unique Ingredient Identifier:
DTI67O9503

About Alglucosidase alfa

Here, you can find what Alglucosidase alfa is used for, in short. Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. Aglucosidase alfa is produced by recombinant DNA technology in a Chinese hamster ovary cell line.

Alglucosidase alfa degrades glycogen by catalyzing the hydrolysis of a-1- and a-1- glycosidic linkages of lysosomal glycogen. Structurally, Alglucosidase alfa is a glycoprotein with a calculated mass of 98,008 daltons for the 883 residue mature polypeptide chain, and a total mass of approximately 109,000 daltons, including carbohydrates. It is used for the treatment of Pompe disease (GAA deficiency) in infants and pediatric patients.

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