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Looking for Alglucosidase alfa API 420784-05-0?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Alglucosidase alfa. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Alglucosidase alfa
- Synonyms:
- Acid maltase , Acid-alpha glucosidase , Aglucosidase alfa , Aglucosidase alpha , alpha-1 , 4-glucosidase , Alpha-glucosidase , Lysosomal Alpha-Glucosidase
- Cas Number:
- 420784-05-0
- DrugBank number:
- DB01272
- Unique Ingredient Identifier:
- DTI67O9503
About Alglucosidase alfa
Here, you can find what Alglucosidase alfa is used for, in short. Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. Aglucosidase alfa is produced by recombinant DNA technology in a Chinese hamster ovary cell line.
Alglucosidase alfa degrades glycogen by catalyzing the hydrolysis of a-1- and a-1- glycosidic linkages of lysosomal glycogen. Structurally, Alglucosidase alfa is a glycoprotein with a calculated mass of 98,008 daltons for the 883 residue mature polypeptide chain, and a total mass of approximately 109,000 daltons, including carbohydrates. It is used for the treatment of Pompe disease (GAA deficiency) in infants and pediatric patients.
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