Clozapine API Manufacturers

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Produced in:

Poland

Established in: 1968

MOQ: 5 kg

Employees: 50+

Warehouse stock of nearly all APIs

GMP, GDP and ISO certified

Customisable (small-sized) packages

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • CoA

  • ISO9001

  • MSDS

  • WC

  • GMP

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Located in:

China

Passed ISO9001:2015 and SGS audit

Provide one-stop CDMO service from R&D to production

Certifications: ISO9001: 2015, HALAL Certificate, Kosher Certification

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

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  • CoA

  • GMP

  • ISO9001

  • CEP

  • MSDS

  • BSE/TSE

  • DMF

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Produced in:

China

Established in: 2011

MOQ: 1 kg

Employees: 10+

Fast Response and Good Communication

Willingness To Start From Small

Flexible Payment Terms

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • CoA

  • BSE/TSE

  • GMP

  • MSDS

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Replies can take a few days

Produced in:

China

Established in: 1923

MOQ: 25 kg

Employees: 20+

Service-oriented company

Global supply chain resilience

Support of your new projects from start to commercial realisation

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • CEP

  • WC

  • GMP

  • CoA

  • MSDS

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Replies quickly

Located in:

China
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • WC

  • CoA

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Replies slower than most

Located in:

Poland

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • GMP

  • CoA

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Replies slower than most

Located in:

China
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

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  • CEP

  • coa

  • DMF

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Replies slower than most

Located in:

China
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • WC

  • FDA

  • CEP

  • coa

  • DMF

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Replies slower than most

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

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  • GMP

  • FDA

  • WC

  • coa

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Replies slower than most

Located in:

China
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • coa

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Replies slower than most

Located in:

Italy

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • GMP

  • FDA

  • CEP

  • coa

  • DMF

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Replies slower than most

Located in:

China
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Replies slower than most

Located in:

Germany

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • FDA

  • coa

  • CEP

  • DMF

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Replies slower than most

Located in:

India

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • GMP

  • FDA

  • CoA

  • CEP

  • WC

  • DMF

Located in:

China
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • WC

  • CoA

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • coa

  • ISO

  • CEP

  • DMF

  • EDQM certificate 2017

  • FDA

Located in:

Spain

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • CEP

  • coa

  • GMP

  • FDA

  • KDMF

  • DMF

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Looking for Clozapine API 5786-21-0?

Description:
Here you will find a list of producers, manufacturers and traders of Clozapine. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:
Clozapine 
Synonyms:
Clozapin , Clozapina , Clozapine , Clozapinum  
Cas Number:
5786-21-0 
DrugBank number:
DB00363 
Unique Ingredient Identifier:
J60AR2IKIC

About Clozapine

Learn more about Clozapine. A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.

Clozapine is a type of Atypical antipsychotics


Atypical antipsychotics belong to the subcategory of pharmaceutical active pharmaceutical ingredients (APIs) used in the treatment of various mental disorders, particularly schizophrenia and bipolar disorder. These medications are designed to alleviate the symptoms of psychosis by targeting specific neuroreceptors in the brain.

Unlike traditional antipsychotics, atypical antipsychotics exhibit a different pharmacological profile, providing a more favorable side effect profile and improved efficacy. These medications primarily act on dopamine and serotonin receptors, regulating the neurotransmitter levels in the brain to restore the chemical balance.

The mechanism of action of atypical antipsychotics involves blocking dopamine receptors, particularly D2 receptors, as well as modulating serotonin receptors, notably 5-HT2A receptors. By inhibiting excessive dopamine transmission and enhancing serotonin activity, atypical antipsychotics help reduce hallucinations, delusions, and other psychotic symptoms.

Some commonly used atypical antipsychotics include risperidone, olanzapine, quetiapine, and aripiprazole. These APIs are typically formulated into oral tablets or capsules for convenient administration.

Despite their effectiveness, atypical antipsychotics may have potential side effects such as weight gain, metabolic abnormalities, sedation, and extrapyramidal symptoms. Therefore, close monitoring and individualized treatment plans are essential to ensure optimal therapeutic outcomes.

In conclusion, atypical antipsychotics are a crucial subcategory of APIs used in the treatment of mental disorders. Their distinct pharmacological profile and mechanism of action make them valuable in managing psychosis while minimizing adverse effects.


Clozapine (Atypical antipsychotics), classified under Antipsychotics


Antipsychotics belong to the pharmaceutical API (Active Pharmaceutical Ingredient) category used to treat psychiatric disorders such as schizophrenia, bipolar disorder, and other related conditions. These medications play a crucial role in managing symptoms associated with psychosis, including hallucinations, delusions, and disorganized thinking.

Antipsychotics work by modulating the levels of neurotransmitters in the brain, particularly dopamine and serotonin. They can be categorized into two classes: first-generation (typical) antipsychotics and second-generation (atypical) antipsychotics. Typical antipsychotics primarily target dopamine receptors, while atypical antipsychotics also affect serotonin receptors.

The pharmaceutical API category of antipsychotics includes various well-known drugs, such as haloperidol, chlorpromazine, risperidone, quetiapine, and olanzapine. These APIs are often formulated into different dosage forms, including tablets, capsules, injections, and oral suspensions, to provide flexibility in administration and patient-specific needs.

Antipsychotics offer relief from psychotic symptoms by stabilizing the imbalanced neurotransmitter activity in the brain. However, they may also have certain side effects, such as sedation, weight gain, extrapyramidal symptoms, and metabolic disturbances. It is essential for healthcare professionals to carefully monitor patients receiving antipsychotic treatment to optimize therapeutic benefits while minimizing adverse effects.

In summary, antipsychotics are a vital category of pharmaceutical APIs used to manage psychiatric disorders by modulating neurotransmitter activity in the brain. Their effectiveness in treating psychosis has made them a cornerstone of mental health treatment, providing much-needed relief to individuals suffering from these conditions.



Clozapine manufacturers | traders | suppliers

We have 17 companies offering Clozapine produced in 4 different countries.

Get in contact with the supplier of your choice:

  • Duchefa Farma B.V. from Netherlands, product country of origin Poland
  • Sinoway industrial Co.,Ltd from China, product country of origin China
  • Shandong Octagon Chemicals Limited from China, product country of origin China
  • Otto Brandes GmbH from Germany, product country of origin China
  • Taizhou Xingming from China, product country of origin China
  • Nobilus Ent from Poland, product country of origin Poland
  • Wuhan Shiji Pharma from China, product country of origin China
  • Shouguang Fukang from China, product country of origin Unknown
  • Natco Pharma from India, product country of origin India
  • Changzhou ComWin from China, product country of origin China
  • Cambrex from Italy, product country of origin Unknown
  • Shanghai Zhongxi Sunve from China, product country of origin China
  • Arevipharma from Germany, product country of origin Unknown
  • Mylan from India, product country of origin India
  • Yantai Dongcheng Bio. from China, product country of origin China
  • ZCL Chemicals from India, product country of origin India
  • Medichem from Spain, product country of origin Unknown

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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