Dorzolamide API Manufacturers

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Produced in:

China

Established in: 2011

MOQ: 100 g

Employees: 10+

Fast Response and Good Communication

Willingness To Start From Small

Flexible Payment Terms

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Produced in:

Unknown

Established in: 1963

MOQ: -

Employees: 800+

World’s 1st exclusive API distributor

Portfolio of 600+ APIs

>250 clients in Europe

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Located in:

France

Distributor

Produced in:

Unknown

MOQ: -

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Located in:

France

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Produced in:

Unknown

MOQ: -

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Produced in:

Unknown

Established in: 1944

MOQ: -

Employees: 4,000

14 international API plant sites

Portfolio of 350+ APIs

Teva is among the world’s largest generic drug/API manufacturers

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Located in:

India

Produced in:

India

MOQ: -

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Located in:

India

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India

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Located in:

India

Produced in:

India

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Looking for Dorzolamide API 120279-96-1?

Description:
Here you will find a list of producers, manufacturers and distributors of Dorzolamide. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:
Dorzolamide 
Synonyms:
Dorzolamid , Dorzolamida , Dorzolamide , Dorzolamidum , Dorzolamide hydrochloride  
Cas Number:
120279-96-1 
DrugBank number:
DB00869 
Unique Ingredient Identifier:
9JDX055TW1

About Dorzolamide

What can you use it for? Dorzolamide is a non-bacteriostatic sulfonamide derivative 2 and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and ocular hypertension. It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes. Unlike oral CA inhibitors, dorzolamide has negligible effects of acid-base or electrolyte disturbances and other systemic adverse effects. First marketed in 1995 dorzolamide is available in ophthalmic solutions as monotherapy marketed as Trusopt 6 or in combination with timolol as Cosopt PF.

Do you want to buy this product? Send an inquiry to the listed suppliers that meets your quality requirements

Dorzolamide is a type of Carbonic anhydrase(II) inhibitors


Carbonic anhydrase (CA) inhibitors are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that specifically target the enzyme carbonic anhydrase II (CAII). CAII is a zinc metalloenzyme that plays a crucial role in the regulation of acid-base balance and fluid secretion in various tissues and organs.

These inhibitors are designed to selectively bind to CAII and inhibit its enzymatic activity. By doing so, they disrupt the conversion of carbon dioxide (CO2) to bicarbonate ions (HCO3-) and protons (H+), which is a fundamental process in many physiological functions.

The inhibition of CAII has been found to be useful in the treatment of several medical conditions. One of the most common applications is in the management of glaucoma, a condition characterized by increased intraocular pressure. By inhibiting CAII in the ciliary body of the eye, these inhibitors reduce the production of aqueous humor, thus lowering the intraocular pressure.

In addition to glaucoma, CAII inhibitors have shown promise in the treatment of other disorders such as epilepsy, edema, and certain types of cancer. Their ability to modulate the pH and ion balance in tissues makes them potential therapeutic agents in a wide range of conditions.

The development of CAII inhibitors involves extensive structure-activity relationship studies and optimization of chemical properties to enhance potency, selectivity, and pharmacokinetic properties. Various structural classes of CAII inhibitors have been synthesized and tested, providing a rich pool of potential drug candidates.

In conclusion, carbonic anhydrase II inhibitors are a valuable subcategory of pharmaceutical APIs that hold promise for the treatment of various medical conditions. Continued research and development in this field may lead to the discovery of novel and effective therapies in the future.


Dorzolamide (Carbonic anhydrase(II) inhibitors), classified under Anticoagulants


Anticoagulants are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) used to prevent and treat blood clotting disorders. These medications play a crucial role in various medical conditions, including deep vein thrombosis (DVT), pulmonary embolism (PE), and atrial fibrillation (AF). Anticoagulants work by inhibiting the formation of blood clots or by preventing existing clots from getting larger.

There are different types of anticoagulants available, including direct thrombin inhibitors, vitamin K antagonists, and factor Xa inhibitors. Direct thrombin inhibitors, such as dabigatran, directly target the enzyme thrombin to hinder clot formation. Vitamin K antagonists, like warfarin, interfere with the production of clotting factors that rely on vitamin K. Factor Xa inhibitors, such as rivaroxaban and apixaban, inhibit the activity of factor Xa, a crucial component in the clotting cascade.

Anticoagulants are commonly prescribed to patients at risk of developing blood clots or those with existing clotting disorders. They are often used during surgeries, such as hip or knee replacements, to minimize the risk of post-operative clot formation. Patients with AF, a condition characterized by irregular heart rhythm, may also be prescribed anticoagulants to prevent stroke caused by blood clots.

While anticoagulants offer significant benefits in preventing and treating clot-related conditions, they also carry potential risks, including bleeding complications. Patients taking anticoagulants require careful monitoring to ensure the right dosage is administered, as excessive anticoagulation can lead to hemorrhage. Regular blood tests and close medical supervision are essential to manage the delicate balance between preventing clots and avoiding excessive bleeding.

In conclusion, anticoagulants are a crucial category of pharmaceutical APIs used to prevent and treat blood clotting disorders. They function by inhibiting clot formation or preventing existing clots from enlarging. While highly beneficial, their use requires careful monitoring to minimize the risk of bleeding complications.



Dorzolamide manufacturers | traders | suppliers

We have 8 companies offering Dorzolamide produced in 3 different countries.

Get in contact with the supplier of your choice:

  • Shandong Octagon Chemicals Limited from China, product country of origin China
  • TIEFENBACHER API + Ingredients from Germany, product country of origin Unknown
  • Quimdis from France, product country of origin Unknown
  • PCAS from France, product country of origin Unknown
  • Teva API from Israel, product country of origin Unknown
  • Indoco Remedies from India, product country of origin India
  • Micro Labs from India, product country of origin India
  • Hetero Drugs from India, product country of origin India

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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