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Located in:

China

Passed ISO9001:2015 and SGS audit

Provide one-stop CDMO service from R&D to production

Certifications: ISO9001: 2015, HALAL Certificate, Kosher Certification

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Produced in:

China

Established in: 2011

MOQ: 1 kg

Employees: 10+

Fast Response and Good Communication

Willingness To Start From Small

Flexible Payment Terms

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Produced in:

China

Established in: 1968

MOQ: 100 g

Employees: 50+

Warehouse stock of nearly all APIs

GMP, GDP and ISO certified

Customisable (small-sized) packages

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Produced in:

Unknown

Established in: 1886

MOQ: -

Employees: 275+

Raw materials, CMO and OTC products

Two GMP certified locations

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Produced in:

China

Established in: 1923

MOQ: 400 kg

Employees: 20+

Service-oriented company

Global supply chain resilience

Support of your new projects from start to commercial realisation

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Located in:

Hungary
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Located in:

India
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Looking for Spironolactone API 52-01-7?

Description:
Here you will find a list of producers, manufacturers and traders of Spironolactone. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:
Spironolactone 
Synonyms:
Espironolactona , Spironolactone , Spironolactonum , Spironolattone , Spironolactone Micronised  
Cas Number:
52-01-7 
DrugBank number:
DB00421 
Unique Ingredient Identifier:
27O7W4T232

About Spironolactone

So, what does it do? Spironolactone is a potassium sparing diuretic like eplerenone that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered1 It is indicated to treat a number of conditions including heart failure, deem, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome. Off label uses of spironolactone involving its antiandrogenic activity include hirsutism, female pattern hair loss, and adult acne vulgaris.

Spironolactone is also frequently used in medical gender transition. Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.

You can find more info about this product by clicking on the DB ID above.

Spironolactone is a type of Diuretics


Diuretics, a subcategory of pharmaceutical active pharmaceutical ingredients (APIs), are compounds commonly used in the treatment of conditions such as hypertension, congestive heart failure, and edema. Diuretics, also known as water pills, function by increasing the production of urine, thereby promoting the excretion of excess water and electrolytes from the body.

There are several types of diuretics, including thiazide diuretics, loop diuretics, and potassium-sparing diuretics. Thiazide diuretics, such as hydrochlorothiazide, work by inhibiting the reabsorption of sodium and chloride in the kidneys, leading to increased urine production. Loop diuretics, such as furosemide, act on the loop of Henle in the kidneys to block the reabsorption of sodium and chloride, resulting in a more potent diuretic effect. Potassium-sparing diuretics, like spironolactone, help retain potassium in the body while still promoting diuresis.

These diuretic APIs are widely used in the pharmaceutical industry to formulate medications that effectively manage fluid retention and related conditions. They are available in various forms, including tablets, capsules, and intravenous formulations. Diuretics are often prescribed as part of combination therapies to enhance their effectiveness and minimize adverse effects.

It is important to note that the use of diuretics should be closely monitored by healthcare professionals due to potential side effects such as electrolyte imbalances, dehydration, and hypotension. Proper dosage and patient-specific considerations are crucial to ensure optimal therapeutic outcomes.

In conclusion, diuretics are a vital subcategory of pharmaceutical APIs used to treat conditions characterized by fluid retention. Their mechanisms of action vary, but they all facilitate increased urine production, assisting the body in eliminating excess fluids. The proper use of diuretics, in combination with medical supervision, can effectively manage various cardiovascular and renal conditions.


Spironolactone (Diuretics), classified under Antihypertensive agents


Antihypertensive agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat high blood pressure, also known as hypertension. These medications are designed to lower blood pressure and reduce the risk of associated cardiovascular complications.

Antihypertensive agents function by targeting various mechanisms involved in blood pressure regulation. Some common classes of antihypertensive agents include angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta-blockers, calcium channel blockers (CCBs), and diuretics.

ACE inhibitors work by inhibiting the enzyme responsible for converting angiotensin I to angiotensin II, a hormone that constricts blood vessels. ARBs, on the other hand, block the receptors to which angiotensin II binds, thereby preventing its vasoconstrictive effects.

Beta-blockers reduce blood pressure by blocking the effects of adrenaline and noradrenaline, which are responsible for increasing heart rate and constricting blood vessels. CCBs inhibit calcium from entering the smooth muscles of blood vessels, resulting in relaxation and vasodilation. Diuretics promote the elimination of excess fluid and sodium from the body, reducing blood volume and thereby lowering blood pressure.

Antihypertensive agents are typically prescribed based on the individual patient's condition and specific needs. They can be used alone or in combination to achieve optimal blood pressure control. It is important to note that antihypertensive agents should be taken regularly as prescribed by a healthcare professional and may require periodic monitoring to ensure their effectiveness and manage any potential side effects.

In summary, antihypertensive agents play a vital role in the management of hypertension by targeting various mechanisms involved in blood pressure regulation. These medications offer significant benefits in reducing the risk of cardiovascular complications associated with high blood pressure.



Spironolactone manufacturers | traders | suppliers

We have 18 companies offering Spironolactone produced in 5 different countries.

Get in contact with the supplier of your choice:

  • Sinoway industrial Co.,Ltd from China, product country of origin China
  • Shandong Octagon Chemicals Limited from China, product country of origin China
  • Duchefa Farma B.V. from Netherlands, product country of origin China
  • Caesar & Loretz GmbH (CAELO) from Germany, product country of origin Unknown
  • Otto Brandes GmbH from Germany, product country of origin China
  • Gedeon Richter from Hungary, product country of origin Unknown
  • Aquatic Remedies Pvt Ltd from India, product country of origin India
  • Hubei Goto Biopharm from China, product country of origin China
  • Tianjin Tianyao from China, product country of origin China
  • Tianjin Tianmao from China, product country of origin China
  • Humble Healthcaare from India, product country of origin India
  • Zhejiang Shenzhou from China, product country of origin China
  • G.D. Searle from United States, product country of origin United States
  • Sanofi from France, product country of origin Unknown
  • Dipharma Francis S.r.l. from Italy, product country of origin Italy
  • Piramal Healthcare from United Kingdom, product country of origin India
  • Tianjin Jinjin from China, product country of origin China
  • Shaoxing Hantai Pharma from China, product country of origin China

Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.

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