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Produced in:
Established in: 2021
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Employees: 19
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Looking for Camostat API 59721-28-7?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Camostat. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Camostat
- Synonyms:
- Camostatum
- Cas Number:
- 59721-28-7
- DrugBank number:
- DB13729
- Unique Ingredient Identifier:
- 0FD207WKDU
General Description:
Camostat, identified by CAS number 59721-28-7, is a notable compound with significant therapeutic applications. Camostat mesylate, or FOY-305, is a synthetic serine protease inhibitor. It was first described in the literature in 1981, as part of research on the inhibition of skin tumors in mice. Camostat mesylate inhibits cholecystokinin, pro-inflammatory cytokines, and serine proteases, leading to it being investigated for multiple indications including the treatment of COVID-19. Camostat mesylate was first approved in Japan in January 2006.
Indications:
This drug is primarily indicated for: Camostat mesylate is indicated in Japan to treat chronic pancreatitis and drug induced lung injury. It is also being investigated as a potential treatment for COVID-19. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Camostat undergoes metabolic processing primarily in: Camostat mesylate is hydrolyzed by carboxyesterate to the active 4-(4-guanidinobenzoyloxy) phenylacetate. The active metabolite is further hydrolyzed by arylesterase to 4-guanidinobenzoic acid. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Camostat are crucial for its therapeutic efficacy: A 200mg oral dose of camostat mesylate leads to the active metabolite reaching a Cmax of 87.1 ± 29.5 ng/mL, with a Tmax of 40 min, and an AUC of 10,400 ± 1,400 ng\*min/mL. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Camostat is an important consideration for its dosing schedule: The half life of camostat mesylate is 3.8-4.7h. This determines the duration of action and helps in formulating effective dosing regimens.
Protein Binding:
Camostat exhibits a strong affinity for binding with plasma proteins: Camostat mesylate is 25.8-28.2% protein bound to human serum proteins _in vitro_. This property plays a key role in the drug's pharmacokinetics and distribution within the body.
Route of Elimination:
The elimination of Camostat from the body primarily occurs through: Camostat mesylate is 89.8-95.6% eliminated in the urine and 1.0-1.7% eliminated in the feces. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Camostat is distributed throughout the body with a volume of distribution of: The volume of distribution at steady state of camostat mesylate is 0.34-1.31L/kg. This metric indicates how extensively the drug permeates into body tissues.
Clearance:
The clearance rate of Camostat is a critical factor in determining its safe and effective dosage: The clearance of camostat mesylate is 4.5-7.3mL/min/kg. It reflects the efficiency with which the drug is removed from the systemic circulation.
Pharmacodynamics:
Camostat exerts its therapeutic effects through: Camostat mesylate is a protease inhibitor used to treat chronic pancreatitis. The duration of action is not long, as it is typically given in 3 divided doses daily. Patients should be counselled regarding the risk of anaphylaxis, thrombocytopenia, hepatic dysfunction, and hyperkalemia. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Camostat functions by: In rats, oral camostat mesylate may increase pancreatic secretions and hypertrophy by increasing cholecystokinin release. Administration in rats has also lead to lower levels of IL-1beta, IL-6, TNF-alpha, TGF-beta, and PSC. Similar activity is seem after administration in humans, leading to reduced pain and inflammation as well as improve the function of the pancrease in chronic pancreatitis. In the case of SARS-CoV-2, camostat mesylate inhibits the action of the serine protease TMPRSS2, preventing the priming of the viral spike protein for attachment to ACE2, and entry into the cell. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Toxicity:
Classification:
Camostat belongs to the class of organic compounds known as depsides and depsidones. These are polycyclic compounds that is either a polyphenolic compound composed of two or more monocyclic aromatic units linked by an ester bond (depside), or a compound containing the depsidone structure (depsidone), classified under the direct parent group Depsides and depsidones. This compound is a part of the Organic compounds, falling under the Phenylpropanoids and polyketides superclass, and categorized within the Depsides and depsidones class, specifically within the None subclass.
Categories:
Camostat is categorized under the following therapeutic classes: Amidines, Antifibrinolytic Agents, Blood and Blood Forming Organs, Enzyme Inhibitors, Guanidines, Hemostatics, Protease Inhibitors, Proteinase Inhibitors, Serine Protease Inhibitors, Trypsin Inhibitors. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Camostat include:
- Melting Point: 194-198
Camostat is a type of Enzyme Replacements/modifiers
Enzyme replacements/modifiers are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) utilized in the treatment of various enzyme-related disorders. Enzymes play a vital role in the normal functioning of the body by catalyzing specific biochemical reactions. However, in certain medical conditions, the body may lack or produce dysfunctional enzymes, leading to serious health complications.
Enzyme replacement therapy (ERT) involves administering exogenous enzymes to compensate for the enzyme deficiency in patients. These enzymes are typically derived from natural sources or produced using recombinant DNA technology. By introducing these enzymes into the body, they can effectively substitute the missing or defective enzymes, thereby restoring normal metabolic processes.
On the other hand, enzyme modifiers are API substances that regulate the activity of specific enzymes within the body. These modifiers can either enhance or inhibit the enzyme's function, depending on the therapeutic objective. By modulating enzyme activity, these APIs can restore the balance of enzymatic reactions, leading to improved physiological outcomes.
Enzyme replacements/modifiers have shown remarkable success in treating various genetic disorders, such as Gaucher disease, Fabry disease, and lysosomal storage disorders. Additionally, they have demonstrated potential in managing enzyme deficiencies associated with rare diseases and certain types of cancer.
The development and production of enzyme replacements/modifiers involve rigorous research, formulation optimization, and adherence to stringent quality control measures. Pharmaceutical companies invest substantial resources in developing these APIs to ensure their safety, efficacy, and compliance with regulatory standards.
Overall, enzyme replacements/modifiers represent a vital therapeutic category in modern medicine, offering hope and improved quality of life for patients with enzyme-related disorders.
Camostat manufacturers | traders | suppliers
We have 1 companies offering Camostat produced in 1 different countries.
Get in contact with the supplier of your choice:
- SETV Global from India, product country of origin India
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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