Clofibrate API Manufacturers

Looking for Clofibrate API 637-07-0?

Description:

Here you will find a list of producers, manufacturers and distributors of Clofibrate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Clofibrate 

Synonyms:

Atromid-S , Clofibrate , Clofibrato , Clofibratum , ELPI , EPIB , Ethyl chlorophenoxyisobutyrate , Ethyl clofibrate , Lipofacton , Liprin  

Cas Number:

637-07-0 

DrugBank number:

DB00636 

Unique Ingredient Identifier:

HPN91K7FU3

Clofibrate is a type of Fibrates

Fibrates are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) used in the treatment of various cardiovascular disorders. These medications primarily target lipid metabolism and are commonly prescribed to manage conditions such as hyperlipidemia and dyslipidemia.

Fibrates work by activating peroxisome proliferator-activated receptors (PPARs) in the liver, which regulate genes involved in lipid metabolism. By stimulating PPARs, fibrates enhance the breakdown of triglycerides and increase the production of high-density lipoprotein (HDL) cholesterol, commonly referred to as "good cholesterol." Simultaneously, they reduce low-density lipoprotein (LDL) cholesterol levels, also known as "bad cholesterol," and decrease the levels of total cholesterol.

The most commonly used fibrates include gemfibrozil, fenofibrate, and bezafibrate. These drugs are available in various formulations such as tablets and capsules for oral administration. Fibrates are typically prescribed in combination with dietary modifications and lifestyle changes to optimize their effectiveness.

Although fibrates are generally well-tolerated, they may have some side effects, including gastrointestinal disturbances, liver enzyme abnormalities, and muscular complications. Therefore, close monitoring of patients is necessary during fibrates therapy.

In conclusion, fibrates are a crucial subcategory of pharmaceutical APIs utilized to manage lipid disorders. By modulating lipid metabolism through PPAR activation, these medications effectively regulate cholesterol levels and improve cardiovascular health. However, medical supervision and regular monitoring are essential to ensure their safe and effective use.

Clofibrate (Fibrates), classified under Lipid-lowering agents

Lipid-lowering agents are a category of pharmaceutical active ingredients (APIs) that are widely used in the treatment of hyperlipidemia, a condition characterized by elevated levels of lipids (such as cholesterol and triglycerides) in the blood. These agents play a crucial role in managing lipid abnormalities and reducing the risk of cardiovascular diseases.

One of the most commonly prescribed lipid-lowering agents is statins. Statins work by inhibiting an enzyme called HMG-CoA reductase, which is responsible for the production of cholesterol in the liver. By blocking this enzyme, statins effectively lower cholesterol levels in the bloodstream.

Another class of lipid-lowering agents is fibric acid derivatives, which primarily target triglyceride levels. These agents activate a nuclear receptor known as PPAR-alpha, which regulates lipid metabolism. By activating PPAR-alpha, fibric acid derivatives enhance the breakdown of triglycerides and increase the elimination of fatty acids from the bloodstream.

Additionally, bile acid sequestrants are often used as lipid-lowering agents. These agents bind to bile acids in the intestine, preventing their reabsorption. As a result, the liver utilizes more cholesterol to produce new bile acids, leading to a decrease in circulating cholesterol levels.

Lipid-lowering agents are available in various formulations, including tablets, capsules, and suspensions, allowing for convenient administration. They are usually prescribed alongside lifestyle modifications, such as dietary changes and regular exercise, to optimize the management of hyperlipidemia.

It is important to note that the use of lipid-lowering agents should be under the supervision of a healthcare professional, as they may have potential side effects and interactions with other medications. Proper monitoring of lipid levels and regular follow-up visits are essential for ensuring the effectiveness and safety of these pharmaceutical agents.

• Syn-tech Chem from Taiwan, product country of origin Taiwan

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