Nadroparin API Manufacturers
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Established in: 2019
MOQ: 1 kg
Focused on pharmaceutical industry
Reasonable price for the customers
Full service from R&D stage to commercial stage
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Looking for Nadroparin API 9041-08-1?
- Here you will find a list of producers, manufacturers and traders of Nadroparin. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
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More information about this product: Nadroparin is a low molecular weight heparin (LMWH) which, when bound to antithrombin III (ATIII), accelerates the inactivation of factor II and factor Xa. Nadroparin halts the coagulation pathway by inhibiting the activation of thrombin (factor IIa) by factor Xa. The amplification of the fibrin clotting cascade is stopped once factors Xa and IIa are inactivated. It is derived from porcine sources and has a mean molecular size of 5000 daltons. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.
Nadroparin is a type of Heparins
Heparins are a vital subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs) widely used in the medical industry. These compounds are derived from the mucous membranes of pigs or cows, and they play a crucial role in preventing and treating blood clotting disorders. This technical description will delve into the key aspects of heparins, highlighting their composition, therapeutic applications, and manufacturing process.
Heparins consist of a complex mixture of sulfated polysaccharides, primarily composed of repeating units of glucuronic acid and N-acetylglucosamine. These chains exhibit high molecular weights, ranging from 3,000 to 30,000 Daltons. Their unique chemical structure and anticoagulant properties make them indispensable in the treatment of conditions like deep vein thrombosis, pulmonary embolism, and during cardiac surgeries.
The production of heparins involves a rigorous extraction process from animal tissues, followed by purification and standardization to ensure consistent quality and efficacy. The raw materials undergo several steps, including depolymerization, fractionation, and removal of impurities, resulting in different forms such as unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH). LMWH offers advantages like improved bioavailability, longer half-life, and reduced risk of certain side effects compared to UFH.
Heparins have found widespread usage in various medical settings, including hospitals, clinics, and home-based treatments. As a potent anticoagulant, they effectively prevent clot formation, minimizing the risk of life-threatening conditions. Additionally, heparins also possess anti-inflammatory and immunomodulatory properties, contributing to their therapeutic efficacy in certain diseases beyond anticoagulation.
In summary, heparins are vital pharmaceutical APIs derived from animal tissues, offering unparalleled anticoagulant effects. Their complex composition, diverse therapeutic applications, and stringent manufacturing processes make them indispensable in modern medicine.
Nadroparin (Heparins), classified under Anticoagulants
Anticoagulants are a vital category of pharmaceutical active pharmaceutical ingredients (APIs) used to prevent and treat blood clotting disorders. These medications play a crucial role in various medical conditions, including deep vein thrombosis (DVT), pulmonary embolism (PE), and atrial fibrillation (AF). Anticoagulants work by inhibiting the formation of blood clots or by preventing existing clots from getting larger.
There are different types of anticoagulants available, including direct thrombin inhibitors, vitamin K antagonists, and factor Xa inhibitors. Direct thrombin inhibitors, such as dabigatran, directly target the enzyme thrombin to hinder clot formation. Vitamin K antagonists, like warfarin, interfere with the production of clotting factors that rely on vitamin K. Factor Xa inhibitors, such as rivaroxaban and apixaban, inhibit the activity of factor Xa, a crucial component in the clotting cascade.
Anticoagulants are commonly prescribed to patients at risk of developing blood clots or those with existing clotting disorders. They are often used during surgeries, such as hip or knee replacements, to minimize the risk of post-operative clot formation. Patients with AF, a condition characterized by irregular heart rhythm, may also be prescribed anticoagulants to prevent stroke caused by blood clots.
While anticoagulants offer significant benefits in preventing and treating clot-related conditions, they also carry potential risks, including bleeding complications. Patients taking anticoagulants require careful monitoring to ensure the right dosage is administered, as excessive anticoagulation can lead to hemorrhage. Regular blood tests and close medical supervision are essential to manage the delicate balance between preventing clots and avoiding excessive bleeding.
In conclusion, anticoagulants are a crucial category of pharmaceutical APIs used to prevent and treat blood clotting disorders. They function by inhibiting clot formation or preventing existing clots from enlarging. While highly beneficial, their use requires careful monitoring to minimize the risk of bleeding complications.
Nadroparin manufacturers | traders | suppliers
We have 3 companies offering Nadroparin from 1 different countries.
Get in contact with the supplier of your choice:
- Apino Pharma Co., Ltd. from China
- Hebei Changshan Bio. from China
- Shandong Chen Zhong from China
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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