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Looking for Siltuximab API 541502-14-1?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Siltuximab. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Siltuximab
- Cas Number:
- 541502-14-1
- DrugBank number:
- DB09036
- Unique Ingredient Identifier:
- T4H8FMA7IM
About Siltuximab
More information about the use of: Siltuximab. Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). Its use is indicated for the treatment of adult patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.
MCD is a rare blood disorder caused by dysregulated IL-6 production, proliferation of lymphocytes, and subsequent enlargement of the lymph nodes. It is administered as a 1 hour intravenous infusion every 3 weeks.
Do you want to buy this product? Send an inquiry to the listed suppliers that meets your quality requirements.
Siltuximab is a type of Interleukin inhibitors
Interleukin inhibitors are a crucial subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a significant role in the treatment of various inflammatory diseases. Interleukins are proteins produced by immune cells and act as chemical messengers in the immune system, regulating immune responses and inflammation. However, when these interleukins become overactive or dysregulated, they can contribute to chronic inflammatory conditions.
Interleukin inhibitors work by targeting specific interleukins and blocking their activity, thereby reducing inflammation and alleviating associated symptoms. These inhibitors are designed to selectively bind to interleukins or their receptors, preventing them from initiating inflammatory responses. By inhibiting interleukins, these APIs can effectively modulate immune system activity and suppress inflammation.
The development of interleukin inhibitors has revolutionized the treatment landscape for various inflammatory diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. These APIs have demonstrated remarkable efficacy in clinical trials, offering patients improved disease management and enhanced quality of life.
The use of interleukin inhibitors as pharmaceutical APIs is based on extensive research and understanding of the complex mechanisms underlying inflammatory diseases. Pharmaceutical companies are continuously investing in research and development to discover novel interleukin inhibitors with enhanced specificity and potency.
In conclusion, interleukin inhibitors are a vital class of pharmaceutical APIs that effectively target and modulate the activity of interleukins, providing a powerful therapeutic approach for managing inflammatory diseases.
Siltuximab (Interleukin inhibitors), classified under Immunomodulators
Immunomodulators, a category of pharmaceutical active pharmaceutical ingredients (APIs), are substances that help regulate and modify the immune response of an individual. These compounds play a crucial role in treating various immune-related disorders and diseases. Immunomodulators work by either enhancing or suppressing the immune system, depending on the specific condition being treated.
Immunomodulators are used in the treatment of autoimmune disorders, such as rheumatoid arthritis, multiple sclerosis, and psoriasis. By suppressing the immune system, these APIs help reduce the overactive immune response associated with these conditions, thereby alleviating symptoms and preventing further damage to the body's tissues.
On the other hand, immunomodulators are also employed to boost the immune system in cases of immunodeficiency disorders. These APIs stimulate the immune response, enabling the body to better fight off infections and diseases. Additionally, immunomodulators are utilized in the prevention and treatment of organ transplant rejection, where they help modulate the immune system to accept the transplanted organ.
The development and production of immunomodulators require rigorous testing and quality control to ensure their safety and efficacy. Pharmaceutical companies carefully formulate these APIs into various dosage forms, including tablets, capsules, injections, and topical preparations, to cater to different patient needs.
In summary, immunomodulators form a vital category of pharmaceutical APIs that regulate and modify the immune system. With their ability to modulate immune responses, these compounds contribute significantly to the management and treatment of various immune-related disorders and diseases, improving the quality of life for many patients.
Siltuximab manufacturers | traders | suppliers
We have 1 companies offering Siltuximab produced in 1 different countries.
Get in contact with the supplier of your choice:
- Janssen Pharma from Belgium, product country of origin Netherlands
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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