Ketoconazole
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Established in: 1968
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Looking for Ketoconazole 65277-42-1?
- API | Excipient name:
- Ketoconazole
- Synonyms:
- Extina , Ketoconazol , Ketoconazole , Ketoconazolum , Ketozole , Nizoral , Nizoral a-D , Xolegel
- Cas Number:
- 65277-42-1
- DrugBank number:
- DB01026
- Unique Ingredient Identifier:
- R9400W927I
About Ketoconazole
Why are people looking for Ketoconazole? Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections. It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus1 Ketoconazole was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, miconazole and clotrimazole, due to its broad spectrum and good absorption. However, it was discovered that ketoconazole produces frequent gastrointestinal side effects and dose-related hepatitis These effects combined with waning efficacy led to its eventual replacement by triazole agents, fluconazole, itraconazole, voriconazole, and posaconazole.
Ketoconazole and its predecessor clotrimazole continue to be used in topical formulations.
More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.
Ketoconazole manufacturers | traders | suppliers
We have 15 companies offering Ketoconazole from 5 different countries.
Get in contact with the supplier of your choice:
- TIEFENBACHER API + Ingredients from Germany
- Xi'an Tian Guangyuan Biotech Co.,Ltd from China
- Duchefa Farma B.V. from Netherlands
- Caesar & Loretz GmbH (CAELO) from Germany
- Gufic Biosciences from India
- Prachi Pharmaceuticals from India
- Unnati Pharmaceuticals Pvt Ltd from India
- Quimica Sintetica from Spain
- Nanjing Baijingyu from China
- Derivados Quimicos from Spain
- Sharon Bio-Medicine from India
- Janssen Pharma from Belgium
- Piramal Healthcare from United Kingdom
- Piramal Pharma Solutions from India
- Shaoxing Hantai Pharma from China
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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