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Located in:

France

Producer

Produced in:

France

Established in: 1952

MOQ: 250 kg

Employees: 550+

API manufacturing (Innovators, Generics and Highly Potent)

A tailor-made and flexible service approach

State-of-the-art analytical services including solid form and QbD laboratories

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Located in:

India

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Produced in:

India

Established in: 1984

MOQ: -

Employees: 21,650

Diverse portfolio of 180+APIs

1754+ DMF across global markets

1100+ patents filed, and more than 70 own patents granted

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HIGHLIGHTED

Located in:

United States

Produced in:

United States

Established in: 1994

MOQ: -

Employees: 50+

26+ years of distribution expertise with regulatory excellence

16 worldwide locations supplying high quality ingredients

All our manufacturer partners are cGMP complaint

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Produced in:

India

Established in: 2018

MOQ: -

Employees: 200+

WHO GMP Approved sites for production

25+ years experience in manufacturing APIs for regulated markets

High quality product & superior client service

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Located in:

China

Produced in:

China

Established in: 1987

MOQ: 1 kg

Passed ISO9001:2015 and SGS audit

Provide one-stop CDMO service from R&D to production

Certifications: ISO9001: 2015, HALAL Certificate, Kosher Certification

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Produced in:

World

Established in: 2005

MOQ: -

Employees: 200+

Portfolio of over 2,000 APIs

Precise quality control

End-to-end global regulatory support

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Slovenia

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Austria

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Produced in:

India

Established in: 1994

MOQ: -

Employees: 4,000

All our 5 plants are top notch and FDA approved

We are a backwards integrated company

We have received 24 CEP’s and 27 USDMF’s

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France

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Looking for Esomeprazole API 119141-88-7?

Description:
Here you will find a list of producers, manufacturers and traders of Esomeprazole. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:
Esomeprazole 
Synonyms:
Esomeprazol , Esomeprazolum , Omeprazole S-form , Perprazole , Esomeprazole magnesium dihydrate  
Cas Number:
119141-88-7 
DrugBank number:
DB00736 
Unique Ingredient Identifier:
N3PA6559FT

About Esomeprazole

Some technical information about this product: Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison (ZE) Syndrome. It can also be found in quadruple regimens for the treatment of H. pylori infections along with other antibiotics including Amoxicillin, Clarithromycin, and Metronidazole, for example Its efficacy is considered similar to other medications within the PPI class including Omeprazole, Pantoprazole, Lansoprazole, Dexlansoprazole, and Rabeprazole. Esomeprazole is the s-isomer of Omeprazole, which is a racemate of the S- and R-enantiomer.

Esomeprazole has been shown to inhibit acid secretion to a similar extent as Omeprazole, without any significant differences between the two compounds in vitro. Esomeprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme at the secretory surface of gastric parietal cells. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. As the binding of esomeprazole to the (H+, K+)-ATPase enzyme is irreversible and new enzyme needs to be expressed in order to resume acid secretion, esomeprazole's duration of antisecretory effect persists longer than 24 hours.

More information such as the structure, indication or toxicity is available on Drugbank, click the ID above.

Esomeprazole is a type of Proton pump inhibitors


Proton pump inhibitors (PPIs) are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) commonly used for the treatment of gastroesophageal reflux disease (GERD), peptic ulcers, and other acid-related gastrointestinal conditions. PPIs work by inhibiting the gastric proton pump, which is responsible for the secretion of stomach acid.

The primary mechanism of PPIs involves blocking the final step in acid production, thereby reducing the amount of acid produced in the stomach. This inhibition occurs by binding irreversibly to the hydrogen-potassium ATPase enzyme system, also known as the proton pump, located on the parietal cells of the stomach lining. By reducing the acid levels, PPIs provide relief from the symptoms of acid reflux, such as heartburn and regurgitation, while promoting the healing of ulcers.

PPIs are available in various formulations, including delayed-release capsules, tablets, and oral suspensions. Some commonly prescribed PPIs include omeprazole, lansoprazole, pantoprazole, and esomeprazole. These medications are typically taken orally, with the dosage and duration of treatment determined by the severity of the condition and the individual patient's needs.

It is important to note that PPIs are intended for short-term use, generally ranging from four to eight weeks. Prolonged use of PPIs may lead to potential side effects, including an increased risk of gastrointestinal infections, vitamin and mineral deficiencies, and bone fractures.

In summary, proton pump inhibitors are a widely used subcategory of pharmaceutical APIs that effectively reduce stomach acid production. While they provide relief from acid-related conditions, careful consideration of their appropriate usage and potential side effects is necessary for optimal patient care.


Esomeprazole (Proton pump inhibitors), classified under Gastrointestinal Agents


Gastrointestinal Agents belong to the pharmaceutical API category that focuses on treating disorders and ailments related to the digestive system. These agents play a crucial role in addressing various gastrointestinal conditions, such as acid reflux, ulcers, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD).

One of the key types of gastrointestinal agents is proton pump inhibitors (PPIs), which work by reducing the production of stomach acid. PPIs help in treating conditions like gastroesophageal reflux disease (GERD) and peptic ulcers. Another essential class of agents is antacids, which neutralize excessive stomach acid, providing relief from heartburn and indigestion.

Gastrointestinal agents also include antispasmodics that alleviate abdominal cramps and spasms associated with conditions like IBS. These drugs work by relaxing the smooth muscles of the digestive tract. Additionally, there are drugs categorized as laxatives that aid in relieving constipation by promoting bowel movements.

Moreover, certain gastrointestinal agents act as antiemetics, effectively reducing nausea and vomiting. These drugs are particularly useful for patients undergoing chemotherapy or experiencing motion sickness.

Pharmaceutical companies develop and manufacture a wide range of gastrointestinal agents in various forms, including tablets, capsules, suspensions, and injections. These agents are typically formulated using active pharmaceutical ingredients (APIs) and other excipients to ensure their efficacy and safety.

In conclusion, gastrointestinal agents form a vital category of pharmaceutical APIs, providing relief from digestive disorders and improving overall gastrointestinal health. The availability of diverse agents catering to different conditions ensures that patients can receive targeted treatment for their specific gastrointestinal needs.



Esomeprazole manufacturers | traders | suppliers

We have 36 companies offering Esomeprazole produced in 7 different countries.

Get in contact with the supplier of your choice:

  • Minakem from France, product country of origin France
  • Dr. Reddy's from India, product country of origin India
  • Rochem International, Inc. from United States, product country of origin United States
  • Gonane Pharma from India, product country of origin India
  • Sinoway industrial Co.,Ltd from China, product country of origin China
  • LGM Pharma from United States, product country of origin World
  • Torrent Pharma from India, product country of origin India
  • Jiangsu Zhongbang from China, product country of origin China
  • Zhejiang Huayi from China, product country of origin China
  • KRKA from Slovenia, product country of origin Unknown
  • Shouguang Fukang from China, product country of origin China
  • Sandoz from Austria, product country of origin Turkey
  • Menovo from China, product country of origin China
  • Rajasthan Antibiotics from India, product country of origin India
  • Lee Pharma from India, product country of origin India
  • Alkem Labs. from India, product country of origin India
  • HEC Pharm from Germany, product country of origin China
  • Zhejiang Changming from China, product country of origin China
  • Vasudha Pharma Chem Ltd. from India, product country of origin India
  • PCAS from France, product country of origin Unknown
  • Zhejiang Neo-Dankong from China, product country of origin China
  • Ehfield Co.,Ltd from China, product country of origin China
  • Zhejiang Yongtai Pharma from China, product country of origin China
  • Srini Pharma from India, product country of origin India
  • Lupin from India, product country of origin Unknown
  • Mac Chem Products from India, product country of origin India
  • Sterile India from India, product country of origin India
  • MSN Life Sciences from India, product country of origin India
  • Glenmark Pharma from India, product country of origin India
  • Jubilant Generics from India, product country of origin India
  • Sun Pharma from India, product country of origin India
  • Emcure Pharma from India, product country of origin India
  • Cipla from India, product country of origin India
  • Zhejiang Jinhua Conba from China, product country of origin China
  • Hetero Drugs from India, product country of origin Unknown
  • Mylan from India, product country of origin India

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