Aliskiren API Manufacturers
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Looking for Aliskiren API 173334-57-1?
- Here you will find a list of producers, manufacturers and traders of Aliskiren. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
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More information about this product: Aliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension. It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. Aliskiren has been proven to efficacious in reducing blood pressure when used alone or in conjunction with other antihypertensive agents.
Ask the supplier for a certificate of analysis to find out more about the quality of Aliskiren.
Aliskiren is a type of Renin inhibitors
Renin inhibitors are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in managing hypertension and related cardiovascular disorders. These inhibitors target renin, an enzyme responsible for initiating the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure and fluid balance in the body.
By inhibiting renin activity, renin inhibitors prevent the conversion of angiotensinogen into angiotensin I, the first step in the RAAS cascade. This mechanism effectively reduces the production of angiotensin II, a potent vasoconstrictor, and aldosterone, a hormone that promotes sodium and water retention. As a result, renin inhibitors help relax blood vessels, decrease peripheral resistance, and decrease fluid volume, ultimately leading to lowered blood pressure.
Renin inhibitors offer several advantages over traditional antihypertensive medications. They provide a targeted approach by directly inhibiting the primary driver of the RAAS system, thereby offering more effective control of blood pressure. Additionally, renin inhibitors may have favorable effects on endothelial function and vascular remodeling, potentially benefiting patients with additional cardiovascular risks.
Some commonly used renin inhibitors include aliskiren, the first-in-class direct renin inhibitor, and other newer agents under development. These medications are typically administered orally and undergo hepatic metabolism for elimination.
Overall, renin inhibitors are a promising class of pharmaceutical APIs that hold significant potential for effectively managing hypertension and improving cardiovascular health. Their targeted mechanism of action and potential additional benefits make them an important tool in the fight against cardiovascular diseases.
Aliskiren (Renin inhibitors), classified under Antihypertensive agents
Antihypertensive agents are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) used to treat high blood pressure, also known as hypertension. These medications are designed to lower blood pressure and reduce the risk of associated cardiovascular complications.
Antihypertensive agents function by targeting various mechanisms involved in blood pressure regulation. Some common classes of antihypertensive agents include angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta-blockers, calcium channel blockers (CCBs), and diuretics.
ACE inhibitors work by inhibiting the enzyme responsible for converting angiotensin I to angiotensin II, a hormone that constricts blood vessels. ARBs, on the other hand, block the receptors to which angiotensin II binds, thereby preventing its vasoconstrictive effects.
Beta-blockers reduce blood pressure by blocking the effects of adrenaline and noradrenaline, which are responsible for increasing heart rate and constricting blood vessels. CCBs inhibit calcium from entering the smooth muscles of blood vessels, resulting in relaxation and vasodilation. Diuretics promote the elimination of excess fluid and sodium from the body, reducing blood volume and thereby lowering blood pressure.
Antihypertensive agents are typically prescribed based on the individual patient's condition and specific needs. They can be used alone or in combination to achieve optimal blood pressure control. It is important to note that antihypertensive agents should be taken regularly as prescribed by a healthcare professional and may require periodic monitoring to ensure their effectiveness and manage any potential side effects.
In summary, antihypertensive agents play a vital role in the management of hypertension by targeting various mechanisms involved in blood pressure regulation. These medications offer significant benefits in reducing the risk of cardiovascular complications associated with high blood pressure.
Aliskiren manufacturers | traders | suppliers
We have 3 companies offering Aliskiren produced in 2 different countries.
Get in contact with the supplier of your choice:
- Chemo Iberica from Spain, product country of origin Spain
- Jubilant Generics from India, product country of origin India
- MSN Labs. from India, product country of origin India
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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