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Dapagliflozin amorphous (Dapagliflozin) API Manufacturers & Suppliers

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Description:

Here you will find a list of producers, manufacturers and distributors of Dapagliflozin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.

API | Excipient name:

Dapagliflozin 

Synonyms:

Dapagliflozin Amorphous , Dapagliflozin Propanediol  

Cas Number:

461432-26-8 

DrugBank number:

DB06292 

Unique Ingredient Identifier:

1ULL0QJ8UC

Dapagliflozin is a type of SGLT2-inhibitors

SGLT2 inhibitors, short for Sodium-Glucose Co-Transporter 2 inhibitors, belong to the pharmaceutical API subcategory utilized in the treatment of type 2 diabetes mellitus (T2DM). These innovative drugs target the SGLT2 protein responsible for reabsorbing glucose in the kidneys, resulting in increased urinary glucose excretion.

By inhibiting SGLT2, these drugs effectively lower blood glucose levels and improve glycemic control in patients with T2DM. This mechanism of action is independent of insulin secretion or sensitivity, making SGLT2 inhibitors an attractive option for individuals who are resistant to or cannot tolerate other diabetes medications.

Some commonly prescribed SGLT2 inhibitors include canagliflozin, dapagliflozin, and empagliflozin. These pharmaceutical APIs are typically formulated into oral tablets, making them convenient for patient administration.

Clinical studies have demonstrated the effectiveness of SGLT2 inhibitors in reducing HbA1c levels, body weight, and blood pressure in patients with T2DM. Additionally, these medications have shown potential cardiovascular benefits, including a decreased risk of cardiovascular events.

However, it is important to note that SGLT2 inhibitors are not suitable for everyone, and their use should be carefully considered in patients with renal impairment or a history of ketoacidosis. Adverse effects may include genitourinary infections and increased risk of dehydration.

Overall, SGLT2 inhibitors are a promising class of pharmaceutical APIs that offer an innovative approach to managing T2DM by targeting renal glucose reabsorption. Ongoing research and development in this field aim to further optimize the therapeutic potential of SGLT2 inhibitors and improve patient outcomes.

Dapagliflozin (SGLT2-inhibitors), classified under Anti-diabetics

Anti-diabetics, belonging to the pharmaceutical API (Active Pharmaceutical Ingredient) category, are a group of compounds designed to manage and treat diabetes mellitus, a chronic metabolic disorder characterized by high blood sugar levels. These medications play a vital role in controlling diabetes and preventing complications associated with the disease.

Anti-diabetics encompass a wide range of drug classes, including biguanides, sulfonylureas, thiazolidinediones, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists. Each class works through different mechanisms to regulate blood sugar levels and improve insulin sensitivity.

Biguanides, such as metformin, reduce glucose production by the liver and enhance insulin sensitivity in peripheral tissues. Sulfonylureas, like glipizide, stimulate insulin secretion from pancreatic beta cells. Thiazolidinediones, including pioglitazone, improve insulin sensitivity in muscle and adipose tissues. DPP-4 inhibitors, such as sitagliptin, increase insulin release and inhibit glucagon secretion. SGLT2 inhibitors, like dapagliflozin, decrease renal glucose reabsorption, leading to increased urinary glucose excretion. GLP-1 receptor agonists, such as exenatide, enhance insulin secretion, suppress glucagon release, slow gastric emptying, and promote satiety.

These anti-diabetic APIs serve as the foundational ingredients for the formulation of various oral tablets, capsules, and injectable medications used in the treatment of diabetes. By targeting different aspects of glucose regulation, they help patients achieve and maintain optimal blood sugar levels, thus reducing the risk of diabetic complications, such as cardiovascular disease, neuropathy, and nephropathy.

It is crucial for healthcare professionals to prescribe and administer these anti-diabetic medications appropriately, considering factors like the patient's medical history, co-existing conditions, and potential drug interactions. Regular monitoring of blood glucose levels and close medical supervision are necessary to ensure effective diabetes management.

In conclusion, anti-diabetics form a critical category of pharmaceutical APIs used for the treatment of diabetes. These compounds, encompassing various drug classes, work through distinct mechanisms to regulate blood sugar levels and improve insulin sensitivity. By facilitating glucose control, anti-diabetic APIs help mitigate the risk of complications associated with diabetes mellitus, ultimately promoting better health outcomes for patients.

• Polpharma from Poland, product country of origin Poland
• Sinoway industrial Co.,Ltd from China, product country of origin China
• Senova Technology Co., Ltd. from China, product country of origin China
• Valence Labs from India, product country of origin India
• Morepen Laboratories Ltd. from India, product country of origin India
• Shandong Octagon Chemicals Limited from China, product country of origin China
• Apino Pharma Co., Ltd. from China, product country of origin China
• Jiangsu Hansoh Pharma from China, product country of origin China
• Honour Lab from India, product country of origin India
• Biocon from India, product country of origin India
• Hikal from India, product country of origin India
• Solfyn International LLP from India, product country of origin China
• Dr. Reddy's from India, product country of origin India
• ALP PHARM from China, product country of origin China
• Fuxing Long Rui Pharma from China, product country of origin China
• Jiangxi Aifeimu Technology Co Ltd from China, product country of origin China
• Harman Finochem from India, product country of origin India
• Finorga from France, product country of origin France
• Raks Pharma from India, product country of origin India
• MSN Labs. from India, product country of origin India
• Siegfried from Germany, product country of origin Germany
• ZCL Chemicals from India, product country of origin India
• Piramal Pharma Solutions from India, product country of origin India
• Micro Labs from India, product country of origin India
• Shaoxing Hantai Pharma from China, product country of origin China
• Lupin from India, product country of origin India
• Sun Pharma from India, product country of origin India

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