Acetylcysteine zidrimer API Manufacturers
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Looking for Acetylcysteine zidrimer API 2736440-65-4?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Acetylcysteine zidrimer. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Acetylcysteine zidrimer
- Synonyms:
- Dendrimer N-acetyl-cysteine , OP 101 , OP-101
- Cas Number:
- 2736440-65-4
- DrugBank number:
- DB16496
- Unique Ingredient Identifier:
- 7JWF1EYH61
General Description:
Acetylcysteine zidrimer is a chemical compound identified by the CAS number 2736440-65-4.
Mechanism of Action:
Acetylcysteine zidrimer functions by: OP-101 is a novel compound that involves n-acetyl cyseine covalently bonded to an inactive dendrimer. In preclinical models, it was shown that OP-101 is selectively taken up by activated microglia, and localizes in areas wehre there is neuroinflammation. In these activated neural cells, OP-101 releases n-acetyl cysteine and helps reduce oxidative stress and inflammation. In multiple animal models, OP-101 was shown to normalize reactive macrophages, shut down cytokine cascades, and attenuate hyperinflammation. Thus, in May 2020, Orpheris, a subsidiary of Ashvattha Therapeutics and the developer of the compound, is pursuing a Phase 2 clinical study on the safety, pharmacokinetics, and efficacy of OP-101 in patients exhibiting severe COVID-19 symptoms (NCT04458298). This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Categories:
Acetylcysteine zidrimer is categorized under the following therapeutic classes: Experimental Unapproved Treatments for COVID-19. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
