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Strontium chloride API Manufacturers & Suppliers

General Description:

Strontium chloride, identified by CAS number 10476-85-4, is a notable compound with significant therapeutic applications. Strontium chloride (SrCl2) is a salt of strontium and chloride. SrCl2 is useful in reducing tooth sensitivity by forming a barrier over microscopic tubules in the dentin containing nerve endings that have become exposed by gum recession . This kind of barrier protection for tooth hypersensitivity has, however, been superseded by other toothpaste formulations and ingredients designed to be nerve calming agents instead . Such strontium chloride toothpaste formulations may subsequently not be available for sale anymore in certain parts of the world .

Indications:

This drug is primarily indicated for: When employed as an ingredient in toothpaste formulations, strontium chloride is predominantly indicated for treating teeth hypersensitivity . Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Metabolism:

Strontium chloride undergoes metabolic processing primarily in: Strontium can bind to proteins and, based on its similarity to calcium, probably forms complexes with various inorganic anions, such as carbonate and phosphate, and carboxylic acids, such as citrate and lactate . Strontium can also interact with ligands that normally bind calcium, like hypoxyapatite, the main component of mineralized bone, and a variety of calcium-binding and calcium transport proteins that are important in the physiological disposition of calcium in cells, including Ca2+ adenosine triphosphatases, Na+Ca+ antiport], and Ca2+ channels . This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.

Absorption:

The absorption characteristics of Strontium chloride are crucial for its therapeutic efficacy: About 30 percent of ingested strontium is absorbed into the blood through the gut . The amount of strontium absorbed tends to decrease with age and is higher (about 60 percent) in children in their first year of life . Once it is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat . About 8 percent of ingested strontium remains in the body after 30 days, and this decreases to about 4 percent after 1 year . The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Strontium chloride is an important consideration for its dosing schedule: Readily accessible information about the half-life of strontium calcium used in toothpastes is not available. This determines the duration of action and helps in formulating effective dosing regimens.

Protein Binding:

Strontium chloride exhibits a strong affinity for binding with plasma proteins: A protein binding of 30-40% has been documented for strontium chloride . This property plays a key role in the drug's pharmacokinetics and distribution within the body.

Route of Elimination:

The elimination of Strontium chloride from the body primarily occurs through: Once strontium is absorbed into the blood, most of it ends up in bone; with the remainder going to soft tissues or being excreted in urine, feces, and sweat . Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.

Volume of Distribution:

Strontium chloride is distributed throughout the body with a volume of distribution of: The distribution of absorbed strontium in the human body is similar to that of calcium, with about 99% of total amount in the body being distributed in the skeleton . This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Strontium chloride is a critical factor in determining its safe and effective dosage: Despite being the major route of excretion of absorbed strontium, urinary excretion of absorbed strontium is observed to be slow . It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Strontium chloride exerts its therapeutic effects through: As an active ingredient in a toothpaste formulation, strontium chloride and the rest of the toothpaste product that it is incorporated into is designed to come into contact with and topically coat the teeth that are being brushed and is not supposed to be swallowed. The regular use of the toothpaste maintains protection that strontium chloride provides against tooth sensitivity despite the normal everyday wear, tear, and cleaning of teeth. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Strontium chloride functions by: For dental hypersensitivity, strontium ions in strontium chloride toothpaste formulations appear to relieve pain and sensitivity by blocking fluid flow in dentinal tubules, which are essentially microscopic canals in the dentin . Regular use of such toothpastes maintains the strontium chloride barricading of the tubules despite normal everyday wear, tear, and washing of teeth. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Toxicity:

Classification:

Strontium chloride belongs to the class of inorganic compounds known as alkaline earth metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a lanthanide, classified under the direct parent group Alkaline earth metal chlorides. This compound is a part of the Inorganic compounds, falling under the Mixed metal/non-metal compounds superclass, and categorized within the Alkaline earth metal salts class, specifically within the Alkaline earth metal chlorides subclass.

Categories:

Strontium chloride is categorized under the following therapeutic classes: Drugs that are Mainly Renally Excreted, Elements, Metals, Metals, Alkaline Earth, Metals, Heavy, Strontium Radioisotopes. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.