Isosorbide API Manufacturers
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Looking for Isosorbide API 652-67-5?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Isosorbide. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Isosorbide
- Synonyms:
- Cas Number:
- 652-67-5
- DrugBank number:
- DB09401
- Unique Ingredient Identifier:
- WXR179L51S
General Description:
Isosorbide, identified by CAS number 652-67-5, is a notable compound with significant therapeutic applications. Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the and forms, and is used for the prevention of angina. Refer to these drug entries for more information.
Indications:
This drug is primarily indicated for: Isosorbide was previously indicated for temporary reduction of intraocular pressure and used to interrupt an acute glaucoma attack, however, this is not a currently approved indication. Refer to and drug entries for more isosorbide indications. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Absorption:
The absorption characteristics of Isosorbide are crucial for its therapeutic efficacy: Isosorbide is rapidly absorbed after oral administration. Refer to for detailed absorption information. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Pharmacodynamics:
Isosorbide exerts its therapeutic effects through: Isosorbide reduces intraocular pressure through its effects on ocular blood vessels. While in the blood, isosorbide promotes redistribution of water toward the circulation, promoting the excretion of urine. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Isosorbide functions by: Isosorbide causes vascular relaxation, reducing systolic ophthalmic artery pressure (SOAP), systolic ocular perfusion pressure (SOPP). This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Isosorbide belongs to the class of organic compounds known as isosorbides. These are organic polycyclic compounds containing an isosorbide(1,4-Dianhydrosorbitol) moiety, which consists of two -oxolan-3-ol rings, classified under the direct parent group Isosorbides. This compound is a part of the Organic compounds, falling under the Organoheterocyclic compounds superclass, and categorized within the Furofurans class, specifically within the Isosorbides subclass.
Categories:
Isosorbide is categorized under the following therapeutic classes: Alcohols, Antianginal Agents, Carbohydrates, Cardiovascular Agents, Diuretics, Diuretics, Osmotic, Natriuretic Agents, Noxae, Organic Nitrates, Terpenes, Vasodilating Agents. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Isosorbide include:
- Water Solubility: 29 mg/mL
- Melting Point: 60-63
- Boiling Point: 175
Isosorbide is a type of Anti-anginal agents
Anti-anginal agents are a category of pharmaceutical active pharmaceutical ingredients (APIs) used for the treatment of angina, a condition characterized by chest pain or discomfort caused by reduced blood flow to the heart muscle. These APIs target the underlying cause of angina, which is often related to insufficient blood supply to the heart.
One commonly used anti-anginal agent is nitroglycerin, which belongs to the class of organic nitrates. Nitroglycerin works by dilating blood vessels, including the coronary arteries that supply blood to the heart. This dilation improves blood flow to the heart, relieving chest pain and reducing the workload on the heart.
Another class of anti-anginal agents is calcium channel blockers (CCBs). CCBs inhibit the movement of calcium ions into heart muscle cells and blood vessel walls. By doing so, they relax and widen blood vessels, enhancing blood flow to the heart and reducing the frequency and severity of angina episodes.
Beta blockers are also commonly used in the treatment of angina. These agents block the effects of adrenaline and other stress hormones on the heart, resulting in reduced heart rate and blood pressure. By slowing down the heart's activity, beta blockers decrease the demand for oxygen and reduce angina symptoms.
Anti-anginal agents play a crucial role in managing angina, providing relief to patients and improving their quality of life. It is important to consult with healthcare professionals for proper diagnosis, prescription, and usage of these pharmaceutical APIs to ensure safe and effective treatment of angina.
