Calcium polycarbophil API Manufacturers
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Looking for Calcium polycarbophil API 126040-58-2?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Calcium polycarbophil. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Calcium polycarbophil
- Synonyms:
- Polycarbophil calcium , Polycarbophil, calcium
- Cas Number:
- 126040-58-2
- DrugBank number:
- DB14684
- Unique Ingredient Identifier:
- 8F049NKY49
General Description:
Calcium polycarbophil, identified by CAS number 126040-58-2, is a notable compound with significant therapeutic applications. Calcium polycarbophil is a stool stabilizer. Based on its chemical structure, it is a synthetic polymer of polyacrylic acid cross-linked with divinyl glycol presenting a calcium atom as a counter-ion. Polycarbophil is used to treat constipation. This drug may also be used to help relieve the symptoms of irritable bowel syndrome or diarrhea. Less gas and bloating compared to psyllium laxative products, but can cause heartburn, and belly cramps. It is insoluble in water, dilute acids, and dilute alkali. The material possesses exceptionally high water-binding capacity. is not absorbed, does not interfere with the activity of digestive enzymes or intestinal absorption, possesses satisfactory stability, is physiologically inert, and does not cause gastrointestinal irritation.
Indications:
This drug is primarily indicated for: Polycarbophil is used to treat constipation and to help maintain regular bowel movements. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Metabolism:
Calcium polycarbophil undergoes metabolic processing primarily in: Polycarrbophil calcium is not metabolized and has limited hydrophilic activity in acidic environments. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.
Absorption:
The absorption characteristics of Calcium polycarbophil are crucial for its therapeutic efficacy: Calcium polycarbophil is not absorbed from the intestine. The drug's ability to rapidly penetrate into cells ensures quick onset of action.
Half-life:
The half-life of Calcium polycarbophil is an important consideration for its dosing schedule: Calcium polycarbophil is not absorbed from the intestine. This determines the duration of action and helps in formulating effective dosing regimens.
Protein Binding:
Calcium polycarbophil exhibits a strong affinity for binding with plasma proteins: Calcium polycarbophil is not absorbed from the intestine. This property plays a key role in the drug's pharmacokinetics and distribution within the body.
Route of Elimination:
The elimination of Calcium polycarbophil from the body primarily occurs through: Excreted in feces. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.
Volume of Distribution:
Calcium polycarbophil is distributed throughout the body with a volume of distribution of: Calcium polycarbophil is not absorbed from the intestine. This metric indicates how extensively the drug permeates into body tissues.
Clearance:
The clearance rate of Calcium polycarbophil is a critical factor in determining its safe and effective dosage: Calcium polycarbophil is not absorbed from the intestine. It reflects the efficiency with which the drug is removed from the systemic circulation.
Pharmacodynamics:
Calcium polycarbophil exerts its therapeutic effects through: Relieves constipation or diarrhea associated with bowel disorders and acute nonspecific diarrhea. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Calcium polycarbophil functions by: It is known as a bulk-forming laxative. It increases the bulk in the stool, an effect that helps to cause movement of the intestines. It also works by increasing the amount of water in the stool, making the stool softer and easier to pass. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Toxicity:
Categories:
Calcium polycarbophil is categorized under the following therapeutic classes: Alimentary Tract and Metabolism, Antidiarrheals, Bulk-Forming Laxatives, Calcium Salts, Compounds used in a research, industrial, or household setting, Drugs for Constipation, Gastrointestinal Agents, Laxatives, Macromolecular Substances, Plastics, Polymers, Resins, Synthetic. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Calcium polycarbophil is a type of Antidiarrheals
Antidiarrheals are a category of pharmaceutical active pharmaceutical ingredients (APIs) that are commonly used to treat diarrhea. Diarrhea is a common gastrointestinal disorder characterized by frequent loose or watery stools. It can be caused by various factors, including viral or bacterial infections, food poisoning, medication side effects, or digestive disorders.
Antidiarrheals work by targeting the underlying causes of diarrhea to alleviate symptoms and restore normal bowel function. These APIs can be classified into several subcategories, including opioids, antimotility agents, and adsorbents.
Opioid-based antidiarrheals, such as loperamide, function by slowing down intestinal motility and reducing excessive bowel contractions. By doing so, they help to decrease the frequency and urgency of bowel movements.
Antimotility agents, such as diphenoxylate with atropine, act on the intestinal muscles to inhibit peristalsis, the wave-like movements that propel stool through the intestines. This helps to slow down the passage of stools and allows for more efficient absorption of fluids and electrolytes.
Adsorbent antidiarrheals, like activated charcoal, function by binding to toxins and bacteria in the digestive tract, preventing their absorption and facilitating their elimination from the body.
Overall, antidiarrheals are valuable pharmaceutical APIs that provide relief from diarrhea by addressing its underlying causes. It is important to note that these medications should be used under the guidance of healthcare professionals, as the appropriate choice of antidiarrheal and dosage may vary depending on the specific condition and patient characteristics.
