Calcitriol
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Looking for Calcitriol 32222-06-3?
- Description:
- Here you will find a list of producers, manufacturers and traders of Calcitriol. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Calcitriol
- Synonyms:
- Calcijex , Calcitriol , Calcitriolum , Decostriol , Rocaltrol
- Cas Number:
- 32222-06-3
- DrugBank number:
- DB00136
- Unique Ingredient Identifier:
- FXC9231JVH
About Calcitriol
It's time for some technical information for the ones who understand chemistry: Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 15-dihydroxycholecalciferol, or 1alpha5-dihydroxyvitamin D3, 15-dihydroxyvitamin D. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to Vitamin D3 (vitamin D3) in the skin, which is then converted to Calcifediol in the liver and kidneys. Calcifediol undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity Calcitriol is considered to be the most potent metabolite of vitamin D in humans Renal production of calcitriol is stimulated in response to PTH, low calcium and low phosphate Calcitriol plays a role in plasma calcium regulation in concert with parathyroid hormone (PTH) by enhancing absorption of dietary calcium and phosphate from the gastrointestinal tract, promoting renal tubular reabsorption of calcium in the kidneys, and stimulating the release of calcium stores from the skeletal system.
In addition to promoting fatty acid synthesis and inhibiting lipolysis, calcitriol has been demonstrated to increase energy efficiency by suppressing UCP2 expression, which is modulated by signaling pathways of classical nuclear receptors (nVDR), where calcitriol acts as a natural ligand There is also evidence that calcitriol modulates the action of cytokines and may regulate immune and inflammatory response, cell turnover, cell differentiation Administered orally and intravenously, calcitriol is commonly used as a medication in the treatment of secondary hyperparathyroidism and resultant metabolic bone disease, hypocalcemia in patients undergoing chronic renal dialysis, and osteoporosis. It is also available in topical form for the treatment of mild to moderate plaque psoriasis in adults. Calcitriol is marketed under various trade names including Rocaltrol (Roche), Calcijex (Abbott) and Decostriol (Mibe, Jesalis).
Check who is selling Calcitriol in the overview above.
Calcitriol manufacturers | traders | suppliers
We have 14 companies offering Calcitriol from 9 different countries.
Get in contact with the supplier of your choice:
- Shandong Octagon Chemicals Limited from China
- Jesalis Pharma from Germany
- Formosa Labs from Taiwan
- G.C. Chemie Pharmie Ltd from India
- Dishman from Netherlands
- Sichuan Neijiang Huixin Pharmaceutical Co Ltd from China
- Instytut Farma from Poland
- Microbiopharm Japan from Japan
- Mahalaxmi Chemi Pharm from India
- Carbogen AMCIS from Switzerland
- D. K. Pharmachem from India
- Cerbios-Pharma from Switzerland
- Teva API from Israel
- Shaoxing Hantai Pharma from China
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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