Calcitriol | compare suppliers & send inquiries for free
Looking for Calcitriol 32222-06-3?
It's time for some technical information for the ones who understand chemistry: Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 15-dihydroxycholecalciferol, or 1alpha5-dihydroxyvitamin D3, 15-dihydroxyvitamin D. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to Vitamin D3 (vitamin D3) in the skin, which is then converted to Calcifediol in the liver and kidneys. Calcifediol undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity Calcitriol is considered to be the most potent metabolite of vitamin D in humans Renal production of calcitriol is stimulated in response to PTH, low calcium and low phosphate Calcitriol plays a role in plasma calcium regulation in concert with parathyroid hormone (PTH) by enhancing absorption of dietary calcium and phosphate from the gastrointestinal tract, promoting renal tubular reabsorption of calcium in the kidneys, and stimulating the release of calcium stores from the skeletal system.
In addition to promoting fatty acid synthesis and inhibiting lipolysis, calcitriol has been demonstrated to increase energy efficiency by suppressing UCP2 expression, which is modulated by signaling pathways of classical nuclear receptors (nVDR), where calcitriol acts as a natural ligand There is also evidence that calcitriol modulates the action of cytokines and may regulate immune and inflammatory response, cell turnover, cell differentiation Administered orally and intravenously, calcitriol is commonly used as a medication in the treatment of secondary hyperparathyroidism and resultant metabolic bone disease, hypocalcemia in patients undergoing chronic renal dialysis, and osteoporosis. It is also available in topical form for the treatment of mild to moderate plaque psoriasis in adults. Calcitriol is marketed under various trade names including Rocaltrol (Roche), Calcijex (Abbott) and Decostriol (Mibe, Jesalis).
Check who is selling Calcitriol in the overview above.
Calcitriol manufacturers | traders | suppliers
We have 16 companies offering Calcitriol from 9 different countries.
Get in contact with the supplier of your choice:
- Shandong Octagon Chemicals Limited from China
- JINLAN Pharm-Drugs Technology Co., Ltd. from China
- Avik Pharma from India
- Dishman from Netherlands
- Shaoxing Hantai Pharma from China
- Teva API from Israel
- G.C. Chemie Pharmie Ltd from India
- Formosa Labs from Taiwan
- Cerbios-Pharma from Switzerland
- Microbiopharm Japan from Japan
- Jesalis Pharma from Germany
- Instytut Farma from Poland
- Carbogen AMCIS from Switzerland
- D. K. Pharmachem from India
- Mahalaxmi Chemi Pharm from India
- Sichuan Neijiang Huixin Pharmaceutical Co Ltd from China
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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