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Established in: 1991
More than 12 GMP manufacturing facilities (EU, US, India)
Portfolio of more than 240 commercial APIs
We are experts in the cGMP production of highly potent compounds
Established in: 1944
14 international API plant sites
Portfolio of 350+ APIs
Teva is among the world’s largest generic drug/API manufacturers
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Looking for Triethylenetetramine 112-24-3?
- Here you will find a list of producers, manufacturers and traders of Triethylenetetramine. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Trien , TETA , Trientine
- Cas Number:
- DrugBank number:
- Unique Ingredient Identifier:
What makes Triethylenetetramine unique? Triethylenetatramine (TETA) is a highly selective divalent Cu(II) chelator and orphan drug that revereses copper overload in tissues. Its salt form, trientine (triethylenetetramine dihydrochloride or 2,2,2-tetramine) was introduced in 1969 as an alternative to D-penicillamine. It consists of a polyamine-like structure different from D-penicillamine, as it lack sulfhydryl groups. It was previously approved by FDA in 1985 as second-line pharmacotherapy for Wilson's disease.
Although penicillamine treatment is believed to be more extensive, TETA therapy has been shown to be an effective initial therapy, even with patients with decompensated liver disease at the outset, and prolonged TETA treatment is not associated with adverse effects as expected in penicillamine treatment. Its clinical applications on cancer, diabetes mellitus, Alzheimer's disease and vascular demetia are being studied.
Do you want to buy this product? Send an inquiry to the listed suppliers that meets your quality requirements.
Triethylenetetramine is a type of Chelating agents
Chelating agents are a crucial subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a vital role in various medicinal applications. These agents possess a unique ability to form coordination complexes with metal ions, thus facilitating the removal of these ions from biological systems. Chelation is the process of binding metal ions tightly through multiple coordination bonds, forming stable chelates.
Chelating agents find widespread application in pharmaceutical formulations, particularly in the treatment of heavy metal poisoning and metal-related diseases. They act by chelating toxic metal ions, such as lead, mercury, or arsenic, and enhancing their elimination from the body through urine or feces.
In addition to their metal chelation properties, these agents offer several therapeutic benefits. They can improve the bioavailability and stability of pharmaceutical formulations by complexing with metal ions that may otherwise degrade or interact with other compounds in the formulation. Chelation therapy also shows promise in the treatment of certain cardiovascular diseases, as it can help remove calcium deposits from arterial walls.
Commonly used chelating agents in pharmaceuticals include ethylenediaminetetraacetic acid (EDTA), dimercaprol (BAL), and deferoxamine. These agents are carefully selected based on their specific chelating properties and safety profiles.
Overall, chelating agents are indispensable in the pharmaceutical industry due to their ability to effectively bind and remove toxic metal ions from the body. Their diverse applications make them a crucial component in the formulation of medicines, offering therapeutic benefits and improved drug delivery.
Triethylenetetramine (Chelating agents), classified under Others
The others category refers to pharmaceutical APIs that do not fall under specific classifications such as antibiotics, antivirals, analgesics, or cardiovascular drugs. These APIs are diverse in nature and serve various therapeutic purposes, making them a crucial component of pharmaceutical formulations.
Pharmaceutical companies develop APIs in the others category to address specific medical conditions or target novel biological pathways. This category includes APIs used in oncology, neurology, immunology, and other specialized areas of medicine. The APIs in this category are often designed to interact with specific molecular targets or receptors, providing targeted therapeutic effects.
The development of APIs in the others category requires extensive research and testing to ensure their efficacy, safety, and compliance with regulatory standards. Pharmaceutical manufacturers employ advanced techniques such as chemical synthesis, biotechnology, and genetic engineering to produce these APIs.
Due to the broad range of applications and therapeutic uses, APIs in the others category contribute significantly to the advancement of medical treatments. Pharmaceutical companies constantly strive to innovate and discover new APIs within this category to address unmet medical needs and improve patient outcomes.
In conclusion, the others category of pharmaceutical APIs encompasses a diverse range of active ingredients used in drug formulation. These APIs play a crucial role in developing innovative therapies across various therapeutic areas, contributing to advancements in healthcare and patient well-being.
Triethylenetetramine manufacturers | traders | suppliers
We have 7 companies offering Triethylenetetramine from 4 different countries.
Get in contact with the supplier of your choice:
- Curia from United States
- Sumitomo Chemical from Japan
- NAVINTA from United States
- Teva API from Israel
- Biophore India from India
- Emcure Pharma from India
- MSN Organics from India
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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