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Ethylhexyl methoxycrylene API Manufacturers & Suppliers

General Description:

Ethylhexyl methoxycrylene, identified by CAS number 947753-66-4, is a notable compound with significant therapeutic applications. Ethylhexyl methoxycrylene is a photostabilizer that preserves the effectiveness of UV filters by interacting with both the singlet and triplet states . It returns UV filters to their ground states without absorbing sunlight . It is used as a solvent for crystalline UV filters and is easily emulsified and suitable for use in various lotions, creams, sprays, sticks, and gel formulations . It currently enjoys regional approvals in Canada, the EU, and the US .

Indications:

This drug is primarily indicated for: Ethylhexyl methoxycrylene is employed as a photostabilizing agent in various sunscreen products . Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Metabolism:

Ethylhexyl methoxycrylene undergoes metabolic processing primarily in: Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.

Absorption:

The absorption characteristics of Ethylhexyl methoxycrylene are crucial for its therapeutic efficacy: Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . At this time, however, studies demonstrate that the components of most commonly used sunscreens are likely absorbed into the skin at least to some extent - although penetration to deeper tissues and the cutaneous circulation remains limited . Despite the extensive use of sunscreen products around the world, there have been few reports of adverse effects related to their use . The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Ethylhexyl methoxycrylene is an important consideration for its dosing schedule: Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal. This determines the duration of action and helps in formulating effective dosing regimens.

Protein Binding:

Ethylhexyl methoxycrylene exhibits a strong affinity for binding with plasma proteins: Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal. This property plays a key role in the drug's pharmacokinetics and distribution within the body.

Route of Elimination:

The elimination of Ethylhexyl methoxycrylene from the body primarily occurs through: Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.

Volume of Distribution:

Ethylhexyl methoxycrylene is distributed throughout the body with a volume of distribution of: Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal. This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Ethylhexyl methoxycrylene is a critical factor in determining its safe and effective dosage: Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal. It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Ethylhexyl methoxycrylene exerts its therapeutic effects through: As an active ingredient in topical sunscreen products, ethylhexyl methoxycrylene is applied directly onto human skin where it acts as a critical component for conferring photostability to the product's other constituent ingredients, protecting the product as a whole from deterioration in the sunlight . Additionally, considering the high log Pow value (6.05-6.32) and low water solubility, dermal absorption of ethylhexyl methoxycrylene is expected to be low. This is supported by a dermal absorption of less than 5% observed for an acceptable analogue of the notified chemical . Consequently, little systemic exposure and pharmacokinetics are expected and users can freely wash off and re-apply ethylhexyl methoxycrylene containing compounds as necessary. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Ethylhexyl methoxycrylene functions by: Ethylhexyl methoxycrylene is a photostabilizer with exceptionally low singlet (S1) and triplet (T1) energy states . Given these properties, ethylhexyl methoxycrylene is capable of draining the singlet excited state reservoir of UV radiation excited molecules of various sunscreen agents . This action used to be considered impossible because molecules stay in the singlet excited state for a very short period of time - often as short as 13 one-thousandths of a billionth of a second . Ethylhexyl methoxycrylene, however, is a singlet quencher that dramatically reduces the flow of energy to the triplet escited state reservoir . As it quenches the singlet excited state, molecules do not have the chance to get to the triplet excited state reservoir and largely return to the ground state where they can continue functioning . In fact, this mechanism of action of ethylhexyl methoxycrylene is considered as being able to return UV filters to their ground states without absorbing sunlight . Ultimately, because ethylhexyl methoxycrylene can work so quickly, it allows manufacturers to formulate products with combinations of sunscreen ingredients that used to be considered too photo-unstable to be effective . Moreover, ethylhexyl methoxycrylene is easily emulsified, and is suitable for use in lotions, creams, sprays, sticks, and gel formulations . This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Toxicity:

Classification:

Ethylhexyl methoxycrylene belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups, classified under the direct parent group Diphenylmethanes. This compound is a part of the Organic compounds, falling under the Benzenoids superclass, and categorized within the Benzene and substituted derivatives class, specifically within the Diphenylmethanes subclass.