Tetrofosmin API Manufacturers

General Description:

Tetrofosmin, identified by CAS number 127502-06-1, is a notable compound with significant therapeutic applications. Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.

Indications:

This drug is primarily indicated for: Tetrofosmin is indicated to be used as a complex with technetium Tc-99m for scintigraphic imaging of the myocardium following separate administrations under exercise and/or resting conditions. It helps in the delineation of regions of reversible myocardial ischemia in absence of infarcted myocardium. This complex is also used for scintigraphic imaging of the myocardium to identify changes in perfusion induced by pharmacologic stress in patients with known or suspected coronary artery disease. This complex is indicated for the assessment of left ventricular function in patients evaluated for heart disease. Its use in specific medical scenarios underscores its importance in the therapeutic landscape.

Metabolism:

Tetrofosmin undergoes metabolic processing primarily in: This pharmacokinetic property has not been fully studied. This metabolic pathway ensures efficient processing of the drug, helping to minimize potential toxicity and side effects.

Absorption:

The absorption characteristics of Tetrofosmin are crucial for its therapeutic efficacy: After intravenous administration, tetrofosmin is rapidly cleared from the blood and taken up by the heart, skeletal muscle, liver, spleen and kidneys. The drug's ability to rapidly penetrate into cells ensures quick onset of action.

Half-life:

The half-life of Tetrofosmin is an important consideration for its dosing schedule: Refer to. This determines the duration of action and helps in formulating effective dosing regimens.

Protein Binding:

Tetrofosmin exhibits a strong affinity for binding with plasma proteins: Refer to. This property plays a key role in the drug's pharmacokinetics and distribution within the body.

Route of Elimination:

The elimination of Tetrofosmin from the body primarily occurs through: Refer to. Understanding this pathway is essential for assessing potential drug accumulation and toxicity risks.

Volume of Distribution:

Tetrofosmin is distributed throughout the body with a volume of distribution of: This pharmacokinetic property has not been fully studied. This metric indicates how extensively the drug permeates into body tissues.

Clearance:

The clearance rate of Tetrofosmin is a critical factor in determining its safe and effective dosage: Refer to. It reflects the efficiency with which the drug is removed from the systemic circulation.

Pharmacodynamics:

Tetrofosmin exerts its therapeutic effects through: Refer to. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.

Mechanism of Action:

Tetrofosmin functions by: Tetrofosmin normal biodistribution makes it suitable to be used as a myocardial agent as it is uptaken by the myocardial tissue and it presents a very low redistribution after 3-4 hours of administration. After distribution, tetrofosmin is a lipophilic cationic agent which is passively diffused and accumulated in viable myocardial tissue. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.

Toxicity:

Classification:

Tetrofosmin belongs to the class of organic compounds known as organic phosphines and derivatives. These are organic compounds containing a phosphine derivative, with the general formula B1P(R2)R3 (R1-R3=alkyl, aryl), classified under the direct parent group Organic phosphines and derivatives. This compound is a part of the Organic compounds, falling under the Organophosphorus compounds superclass, and categorized within the Organic phosphines and derivatives class, specifically within the None subclass.

Categories:

Tetrofosmin is categorized under the following therapeutic classes: Radioactive Diagnostic Agent. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.

Experimental Properties:

Further physical and chemical characteristics of Tetrofosmin include:

• Water Solubility: Soluble
• Boiling Point: 100ºC