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Calcium Phosphate
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Looking for Calcium Phosphate API 10103-46-5?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Calcium Phosphate. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Calcium Phosphate
- Synonyms:
- calcio fosfato , Calcium phosphates , Phosphoric acid, calcium salt
- Cas Number:
- 10103-46-5
- DrugBank number:
- DB11348
- Unique Ingredient Identifier:
- 97Z1WI3NDX
General Description:
Calcium Phosphate, identified by CAS number 10103-46-5, is a notable compound with significant therapeutic applications. Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes .
Indications:
This drug is primarily indicated for: For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste . Its use in specific medical scenarios underscores its importance in the therapeutic landscape.
Pharmacodynamics:
Calcium Phosphate exerts its therapeutic effects through: Calcium phosphate reacts with acid in the stomach to raise the pH . In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth . As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis. The drug's ability to modulate various physiological processes underscores its efficacy in treating specific conditions.
Mechanism of Action:
Calcium Phosphate functions by: The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH) . Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Calcium Phosphate belongs to the class of inorganic compounds known as alkaline earth metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is an alkaline earth metal, classified under the direct parent group Alkaline earth metal phosphates. This compound is a part of the Inorganic compounds, falling under the Mixed metal/non-metal compounds superclass, and categorized within the Alkaline earth metal oxoanionic compounds class, specifically within the Alkaline earth metal phosphates subclass.
Categories:
Calcium Phosphate is categorized under the following therapeutic classes: Acids, Acids, Noncarboxylic, Alimentary Tract and Metabolism, Biocompatible Materials, Calcium Compounds, Calcium Salts, Ceramics, Compounds used in a research, industrial, or household setting, Mineral Supplements, Phosphate salts, Phosphoric Acids, Phosphorus Acids, Phosphorus Compounds. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
Experimental Properties:
Further physical and chemical characteristics of Calcium Phosphate include:
- Water Solubility: 7.7g/L
- Melting Point: >450
Calcium Phosphate is a type of Electrolytes
Electrolytes are a crucial category of pharmaceutical active pharmaceutical ingredients (APIs) that play a vital role in maintaining the balance of essential ions in the body. These ions include sodium, potassium, calcium, magnesium, and chloride, among others. Electrolytes are responsible for maintaining proper hydration, regulating nerve and muscle function, and supporting various physiological processes.
In the pharmaceutical industry, electrolytes are widely utilized in the formulation of oral rehydration solutions, intravenous fluids, and dialysis solutions. These medications are employed to treat conditions such as dehydration, electrolyte imbalances, and renal dysfunction.
The availability of high-quality electrolyte APIs is of utmost importance to ensure the efficacy and safety of these pharmaceutical products. Pharmaceutical manufacturers rely on reputable suppliers who adhere to stringent quality control measures and comply with Good Manufacturing Practices (GMP) to produce electrolyte APIs of consistent quality.
To meet regulatory requirements, electrolyte APIs undergo rigorous testing to confirm their identity, purity, and potency. This includes analysis using advanced techniques such as high-performance liquid chromatography (HPLC), mass spectrometry (MS), and atomic absorption spectroscopy (AAS).
In conclusion, electrolytes are a vital category of pharmaceutical APIs used to maintain the balance of essential ions in the body. They are extensively employed in various medications aimed at treating dehydration, electrolyte imbalances, and renal dysfunction. Pharmaceutical manufacturers prioritize the use of high-quality electrolyte APIs to ensure the safety and efficacy of their products, and adherence to stringent regulatory standards is crucial in their production and testing processes.
