Dimethyl fumarate

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Description:

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API | Excipient name:

Dimethyl fumarate 

Synonyms:

dimethyl (E) butenedioate , Fumaric acid , dimethyl ester , Tecfidera , trans-1 , 2-Ethylenedicarboxylic acid dimethyl ester , trans-Butenedioic acid dimethyl ester  

Cas Number:

624-49-7 

DrugBank number:

DB08908 

Unique Ingredient Identifier:

FO2303MNI2

Dimethyl fumarate is a type of Immunosuppressants

Immunosuppressants are a vital subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in medical treatments. These substances are designed to suppress or weaken the immune system's response, making them invaluable in various therapeutic applications.

Immunosuppressants find extensive use in the management of autoimmune diseases, organ transplantation, and the prevention of rejection reactions. By modulating the immune system's activity, these APIs help control excessive immune responses that can lead to tissue damage and chronic inflammation.

There are different classes of immunosuppressants, including corticosteroids, calcineurin inhibitors, antimetabolites, and biologics. Each class targets specific immune pathways to achieve the desired therapeutic effect. Corticosteroids, for instance, are known for their potent anti-inflammatory properties, making them effective in managing conditions such as rheumatoid arthritis and asthma.

Calcineurin inhibitors like cyclosporine and tacrolimus act by inhibiting the activity of calcineurin, a protein involved in immune cell activation. These drugs are commonly used in organ transplantation to prevent the immune system from attacking the transplanted organ.

Antimetabolites interfere with DNA synthesis and cell proliferation, thereby dampening immune responses. They are often prescribed for conditions like psoriasis and rheumatoid arthritis.

Biologic immunosuppressants, such as monoclonal antibodies, target specific immune cells or molecules involved in the disease process. They have revolutionized the treatment of autoimmune diseases like rheumatoid arthritis, Crohn's disease, and psoriasis.

Immunosuppressants require careful administration and monitoring due to their potential side effects and interactions with other medications. Close collaboration between healthcare professionals, pharmacists, and patients is essential to ensure the safe and effective use of these APIs in various therapeutic settings.

Overall, immunosuppressants represent a critical category of pharmaceutical APIs that significantly contribute to improving patients' quality of life by controlling the immune system's activity and managing various autoimmune conditions and transplantation outcomes.

Dimethyl fumarate (Immunosuppressants), classified under Immunomodulators

Immunomodulators, a category of pharmaceutical active pharmaceutical ingredients (APIs), are substances that help regulate and modify the immune response of an individual. These compounds play a crucial role in treating various immune-related disorders and diseases. Immunomodulators work by either enhancing or suppressing the immune system, depending on the specific condition being treated.

Immunomodulators are used in the treatment of autoimmune disorders, such as rheumatoid arthritis, multiple sclerosis, and psoriasis. By suppressing the immune system, these APIs help reduce the overactive immune response associated with these conditions, thereby alleviating symptoms and preventing further damage to the body's tissues.

On the other hand, immunomodulators are also employed to boost the immune system in cases of immunodeficiency disorders. These APIs stimulate the immune response, enabling the body to better fight off infections and diseases. Additionally, immunomodulators are utilized in the prevention and treatment of organ transplant rejection, where they help modulate the immune system to accept the transplanted organ.

The development and production of immunomodulators require rigorous testing and quality control to ensure their safety and efficacy. Pharmaceutical companies carefully formulate these APIs into various dosage forms, including tablets, capsules, injections, and topical preparations, to cater to different patient needs.

In summary, immunomodulators form a vital category of pharmaceutical APIs that regulate and modify the immune system. With their ability to modulate immune responses, these compounds contribute significantly to the management and treatment of various immune-related disorders and diseases, improving the quality of life for many patients.

• Shilpa Medicare Ltd from India
• Laboratorium Ofichem B.V. from Netherlands
• Vasudha Pharma Chem Ltd. from India
• SENOVA Technology Co., Ltd. from China
• Chongqing Huapont from China
• Natco Pharma from India
• Chinoin from Hungary
• Yabao Pharma from China
• PLIVA from Czech Republic
• Intas Pharma from United Kingdom
• Raks Pharma from India
• Alkem Labs. from India
• Sionc Pharma from India
• Arevipharma from Germany
• Zhejiang Huahai Pharma from China
• Unichem Labs. from India
• Cadila Healthcare from India
• Torrent Pharma from India
• Honour Lab from India
• Sun Pharma from India
• Biophore India from India
• Granules India from India
• Aurobindo from India
• Mylan from India
• Optimus Drugs Pvt Ltd from India
• Dr. Reddy's from India
• Micro Labs from India
• MSN Organics from India
• Glenmark Pharma from India

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