Immunosuppressants


Immunosuppressants are a vital subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in medical treatments. These substances are designed to suppress or weaken the immune system's response, making them invaluable in various therapeutic applications.

Immunosuppressants find extensive use in the management of autoimmune diseases, organ transplantation, and the prevention of rejection reactions. By modulating the immune system's activity, these APIs help control excessive immune responses that can lead to tissue damage and chronic inflammation.

There are different classes of immunosuppressants, including corticosteroids, calcineurin inhibitors, antimetabolites, and biologics. Each class targets specific immune pathways to achieve the desired therapeutic effect. Corticosteroids, for instance, are known for their potent anti-inflammatory properties, making them effective in managing conditions such as rheumatoid arthritis and asthma.

Calcineurin inhibitors like cyclosporine and tacrolimus act by inhibiting the activity of calcineurin, a protein involved in immune cell activation. These drugs are commonly used in organ transplantation to prevent the immune system from attacking the transplanted organ.

Antimetabolites interfere with DNA synthesis and cell proliferation, thereby dampening immune responses. They are often prescribed for conditions like psoriasis and rheumatoid arthritis.

Biologic immunosuppressants, such as monoclonal antibodies, target specific immune cells or molecules involved in the disease process. They have revolutionized the treatment of autoimmune diseases like rheumatoid arthritis, Crohn's disease, and psoriasis.

Immunosuppressants require careful administration and monitoring due to their potential side effects and interactions with other medications. Close collaboration between healthcare professionals, pharmacists, and patients is essential to ensure the safe and effective use of these APIs in various therapeutic settings.

Overall, immunosuppressants represent a critical category of pharmaceutical APIs that significantly contribute to improving patients' quality of life by controlling the immune system's activity and managing various autoimmune conditions and transplantation outcomes.

NameCAS numberCategoryAmount of suppliersAPI market price
Apremilast608141-41-9ImmunosuppressantsView 36 Suppliers Average price per kg: $
Azathioprine446-86-6ImmunosuppressantsView 21 Suppliers Average price per kg: $
Cyclosporine59865-13-3ImmunosuppressantsView 27 Suppliers Average price per kg: $
Dimethyl fumarate624-49-7ImmunosuppressantsView 41 Suppliers Average price per kg: $
Diroximel Fumarate1156109-27-2ImmunosuppressantsView 4 Suppliers Average price per kg: $
ElafinImmunosuppressantsView 1 Suppliers Average price per kg: $
Etanercept185243-69-0ImmunosuppressantsView 3 Suppliers Average price per kg: $
Everolimus159351-69-6ImmunosuppressantsView 21 Suppliers Average price per kg: $
Fingolimod162359-55-9ImmunosuppressantsView 28 Suppliers Average price per kg: $
Glatiramer Acetate147245-92-9ImmunosuppressantsView 17 Suppliers Average price per kg: $
Leflunomide75706-12-6ImmunosuppressantsView 15 Suppliers Average price per kg: $
Mycophenolate mofetil128794-94-5ImmunosuppressantsView 43 Suppliers Average price per kg: $
Mycophenolic acid24280-93-1ImmunosuppressantsView 15 Suppliers Average price per kg: $
Omalizumab242138-07-4ImmunosuppressantsView 1 Suppliers Average price per kg: $
Siponimod1230487-00-9ImmunosuppressantsView 3 Suppliers Average price per kg: $
Sirolimus53123-88-9ImmunosuppressantsView 25 Suppliers Average price per kg: $
Teriflunomide163451-81-8ImmunosuppressantsView 27 Suppliers Average price per kg: $
Tofacitinib477600-75-2ImmunosuppressantsView 26 Suppliers Average price per kg: $
Tranilast53902-12-8ImmunosuppressantsView 2 Suppliers Average price per kg: $