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Looking for Leucovorin API 58-05-9?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Leucovorin. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Leucovorin
- Synonyms:
- 5-Formyltetrahydrofolate , Acide folinique , folinate , Folinic acid , Leucovorinum
- Cas Number:
- 58-05-9
- DrugBank number:
- DB00650
- Unique Ingredient Identifier:
- Q573I9DVLP
About Leucovorin
More information about this product: Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin) is the 5-formyl derivative of tetrahydrofolic acid, a necessary co-factor in the body. Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro, the levo-isomer has been shown to be rapidly converted to the biologically available methyl-tetrahydrofolate form while the dextro form is slowly excreted by the kidneys. Despite this difference in activity, the two commercially available forms have been shown to be pharmacokinetically identical and may be used interchangeably with limited differences in efficacy or side effects (Kovoor et al, 2009).
As folate analogs, leucovorin and levoleucovorin are both used to counteract the toxic effects of folic acid antagonists, such as methotrexate, which act by inhibiting the enzyme dihydrofolate reductase (DHFR). They are indicated for use as rescue therapy following use of high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid antagonists. Injectable forms are also indicated for use in the treatment of megaloblastic anemias due to folic acid deficiency when oral therapy is not feasible and for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.
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Leucovorin is a type of Antidotes
Antidotes are a vital subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in counteracting the toxic effects of certain substances or drugs. These specialized substances are developed to treat and reverse the harmful effects caused by accidental or intentional poisonings, drug overdoses, or adverse reactions.
Antidotes work through various mechanisms to neutralize or counteract the toxic effects of specific substances. They may function by binding to the toxin directly, preventing it from interacting with its target receptors or enzymes. Alternatively, they may stimulate enzymatic pathways that metabolize and eliminate the toxic substance from the body more rapidly.
The development of antidotes involves rigorous research and testing to ensure their safety and efficacy. Clinical trials are conducted to evaluate their effectiveness in treating poisoning cases and to establish appropriate dosing regimens. Furthermore, antidotes are subject to stringent regulatory guidelines to ensure their quality, purity, and consistency.
Medical professionals, particularly toxicologists and emergency healthcare providers, rely on antidotes to manage and treat poisoning emergencies effectively. Antidotes are essential tools in the emergency department and poison control centers, where timely administration can be life-saving.
In summary, antidotes are specialized pharmaceutical APIs designed to counteract the toxic effects of specific substances. Their development, testing, and regulatory compliance are crucial to ensure their efficacy and safety. These critical medications are indispensable in the field of emergency medicine and play a pivotal role in saving lives affected by poisoning incidents.
Leucovorin (Antidotes), classified under Antidotes, Deterrents, and Toxicologic Agents
Antidotes, Deterrents, and Toxicologic Agents are an important category of pharmaceutical Active Pharmaceutical Ingredients (APIs) that play a critical role in healthcare and toxicology. These substances are designed to counteract the effects of poisons, toxins, and overdoses, thereby saving lives and preventing severe health consequences.
Antidotes are substances that neutralize the toxic effects of certain drugs, chemicals, or poisons. They work by either directly binding to the toxic substance or by blocking its harmful actions on the body. Antidotes are administered in emergency situations to quickly reverse the effects of poisoning and restore normal physiological functions.
Deterrents, on the other hand, are pharmaceutical agents used to discourage or prevent harmful behaviors, such as substance abuse. They are designed to make the ingestion or misuse of certain substances unpleasant or less desirable. Deterrents can be formulated to cause unpleasant side effects, such as nausea or vomiting, when a particular substance is consumed in excessive amounts.
Toxicologic agents encompass a broad range of pharmaceutical APIs used in toxicology studies and research. These substances are employed to investigate the toxicity, metabolism, and mechanisms of action of various chemicals and compounds. Toxicologic agents are vital for understanding the potential hazards and risks associated with certain substances, ensuring the safety of drugs, and developing effective treatments for poisoning cases.
In conclusion, Antidotes, Deterrents, and Toxicologic Agents are essential categories of pharmaceutical APIs that address poisoning emergencies, deter harmful behaviors, and enable toxicological research. Their development and availability are crucial for safeguarding public health, enhancing patient care, and advancing our understanding of toxicology.
Leucovorin manufacturers | traders | suppliers
We have 2 companies offering Leucovorin produced in 0 different countries.
Get in contact with the supplier of your choice:
- Huzhou Zhanwang from China, product country of origin China
- Cerbios-Pharma from Switzerland, product country of origin Switzerland
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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