Mipomersen API Manufacturers
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Looking for Mipomersen API 1000120-98-8?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Mipomersen. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Mipomersen
- Cas Number:
- 1000120-98-8
- DrugBank number:
- DB05528
- Unique Ingredient Identifier:
- 9GJ8S4GU0M
About Mipomersen
What can you use it for? Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. Mipomersen is indicated in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering medications. It is marketed under the brand name Kynamro in the United States, and the FDA label includes a black box warning of hepatoxicity.
Specifically, elevations in the liver enzymes, i.e. transaminases, and in liver fat (hepatic steatosis) have been reported. Due to this serious risk of liver toxicity, mipomersen sodium is only available to patients under the restricted program called Kynamro Risk Evaluation and Mitigation Strategy program.
You can ask the supplier for more technical information about the product.
