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Looking for Nicorandil API 65141-46-0?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Nicorandil. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Nicorandil
- Cas Number:
- 65141-46-0
- DrugBank number:
- DB09220
- Unique Ingredient Identifier:
- 260456HAM0
About Nicorandil
Here you will find more information about Nicorandil. Nicorandil is an orally efficacious vasodilatory drug and antianginal agent marketed in the UK, Australia, most of Europe, India, Philippines, Japan, South Korea, and Taiwan. It is not an approved drug by FDA. It is a niacinamide derivative that induces vasodilation of arterioles and large coronary arteries by activating potassium channels.
It is often used for patients with angina who remain symptomatic despite optimal treatment ith other antianginal drugs. Nicorandil is a dual-action potassium channel opener that relaxes vascular smooth muscle through membrane hyperpolarization via increased transmembrane potassium conductance and increased intracellular concentration of cyclic GMP. It is shown to dilate normal and stenotic coronary arteries and reduces both ventricular preload and afterload.
Ask the supplier for a certificate of analysis to find out more about the quality of Nicorandil.
Nicorandil is a type of Potassium channel blockers
Potassium channel blockers belong to the subcategory of pharmaceutical active pharmaceutical ingredients (APIs) used in the development of drugs targeting potassium channels. These blockers play a crucial role in the regulation of various physiological processes in the human body. Potassium channels are membrane proteins that allow the selective passage of potassium ions across cell membranes. They are involved in maintaining the electrical activity of cells, including nerve cells, muscle cells, and cardiac cells. By selectively blocking these channels, potassium channel blockers can modulate cellular excitability and influence various physiological functions.
In the field of medicine, potassium channel blockers have found application in the treatment of several disorders, including cardiovascular diseases, epilepsy, and neuropathic pain. By inhibiting the potassium channels, these blockers can effectively regulate abnormal electrical activity in the heart, brain, and other tissues.
Pharmaceutical companies employ various strategies to develop potassium channel blockers as API for drug formulation. These strategies involve chemical synthesis, molecular modeling, and structure-activity relationship studies to design compounds with high selectivity and affinity for specific potassium channels.
The development of potassium channel blockers requires rigorous testing to evaluate their pharmacokinetic and pharmacodynamic properties, safety, and efficacy. Preclinical and clinical studies are conducted to assess the drug's therapeutic potential and identify any potential adverse effects.
In conclusion, potassium channel blockers are an important subcategory of pharmaceutical APIs used in the development of drugs targeting potassium channels. Their ability to modulate cellular excitability makes them valuable therapeutic agents for treating various disorders, particularly those involving abnormal electrical activity in the body.
Nicorandil (Potassium channel blockers), classified under Anti-arrhythmics
Anti-arrhythmics belong to the pharmaceutical API category designed to treat irregular heart rhythms, also known as arrhythmias. These medications work by targeting the electrical signals in the heart, helping to regulate the heart's rhythm and restore it to a normal, steady beat.
Anti-arrhythmics are crucial in managing various types of arrhythmias, such as atrial fibrillation, ventricular tachycardia, and supraventricular tachycardia. These conditions can pose serious risks, including an increased likelihood of stroke or heart failure. Hence, anti-arrhythmics play a vital role in improving patient outcomes and reducing these associated risks.
Pharmaceutical companies develop anti-arrhythmic APIs, which are the active ingredients used to formulate the final medications. These APIs undergo rigorous testing and quality control measures to ensure their safety, efficacy, and consistent performance. They are manufactured in accordance with Good Manufacturing Practices (GMP) guidelines to meet the highest quality standards.
Healthcare professionals prescribe anti-arrhythmics based on the specific arrhythmia type, severity, and individual patient factors. These APIs can be formulated into different dosage forms, including tablets, capsules, or intravenous solutions, depending on the desired route of administration and patient requirements.
It is important to note that anti-arrhythmics are prescription-only medications and should only be used under medical supervision. Patients using these medications must follow their healthcare provider's instructions and regularly monitor their heart rhythm to ensure optimal treatment effectiveness and minimize potential side effects.
In conclusion, anti-arrhythmics are a crucial category of pharmaceutical APIs used to treat various types of irregular heart rhythms. They are formulated into medications that help regulate the heart's electrical signals, reduce associated risks, and improve patient outcomes.
Nicorandil manufacturers | traders | suppliers
We have 6 companies offering Nicorandil produced in 0 different countries.
Get in contact with the supplier of your choice:
- AXXO GmbH from Germany, product country of origin European Union
- Vital Laboratories Pvt. Ltd. from India, product country of origin India
- Rpg Life Sciences from India, product country of origin India
- S.I.M.S. from Italy, product country of origin Italy
- Procos from Italy, product country of origin Italy
- Edmond Pharma (Recipharm) from Italy, product country of origin Italy
Let the supplier know whether you are looking for a product with a specific monograph such as EP (Ph. Eur.), USP, JP, BP or another quality. Or, whether you are looking for hydrochloride (HCl), anhydricum, base, micronisatum or a specific purity.
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