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Osimertinib API Manufacturers
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Date | Seller | Exporter country | Buyer | Importer country | Product | Quantity (KG) | Price per KG | Latest transactions |
---|---|---|---|---|---|---|---|---|
19-Sep-2024 | (Hidden) | India | AZISTA BHU... | Bhutan | OSIMERTINI... | 3.60 | $ @36$-7! | Check all data |
12-Sep-2024 | (Hidden) | India | EASTERN BA... | Bangladesh | OSIMERTINI... | 0.25 | $ @36$-7! | |
12-Sep-2024 | (Hidden) | India | AZISTA BHU... | Bhutan | OSIMERTINI... | 10 | $ @36$-7! |
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Produced in:
Established in: 2008
MOQ: 1 kg
Employees: 300+
More than 150 patents based on independent intelligence
Expertise in anti-tumor, anti-diabetes and cardiovascular API and intermediates.
GMP facility with annual production capacity of 300M
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Engaged in the production of small molecule chemical drug APIs and preparations
Provide CDMO services for high-activity anti-tumor characteristic APIs
153-acre API and preparation production base
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Producer
Produced in:
Established in: 2021
MOQ: -
Employees: 19
API, Intermediates, Building Blocks, Impurities, Amino acids and Peptides
Small quantity APIs to commercial scale
GMP and USFDA certification based on quantity, order, assignment.
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Producer
Produced in:
Established in: 2019
MOQ: 1 kg
Employees: 10+
Focused on pharmaceutical industry
Reasonable price for the customers
Full service from R&D stage to commercial stage
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Distributor
Produced in:
Established in: 2011
MOQ: 10 g
Employees: 10+
Fast Response and Good Communication
Willingness To Start From Small
Flexible Payment Terms
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Producer
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Producer
Produced in:
Established in: 2005
MOQ: -
Employees: 500
Platinum drugs rank Top 3 in the Chinese market
Dedicated to producing anti-cancer, anti-tumor, anti-fungal, and other APIs and Intermediates
Plants with GMP standard
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Producer
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Looking for Osimertinib API 1421373-65-0?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Osimertinib. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Osimertinib
- Synonyms:
- Mereletinib
- Cas Number:
- 1421373-65-0
- DrugBank number:
- DB09330
- Unique Ingredient Identifier:
- 3C06JJ0Z2O
About Osimertinib
What makes Osimertinib unique? Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals. Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing and which has progressed following therapy with a first-generation EGFR tyrosine kinase inhibitor. Approximately 10% of patients with NSCLC have a rapid and clinically effective response to EGFR-TKIs due to the presence of specific activating EGFR mutations within the tumour cells. More specifically, deletions around the LREA motif in exon 19 and exon 21 L858R point mutations are correlated with response to therapy.
Development of third-generation EGFR-TKIs, such as osimertinib, has been in response to altered tumour resistance patterns following treatment and toxic side effects that impact patient quality of life. Treatment with first-generation EGFR-TKIs (gefitinib and erlotinib) has been associated with the development of resistance through activating mutations in the EGFR gene. Second-generation EGFR-TKIs (afatinib and dacomitinib) were then developed to be more potent inhibitors, although their use is associated with increased toxicity through nonspecific targeting of wild-type EGFR. In contrast, third-generation inhibitors are specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease. Furthermore, osimertinib has been shown to spare wild-type EGFR during therapy, thereby reducing non-specific binding and limiting toxicity.
Check who is selling Osimertinib in the overview above.
Osimertinib is a type of Protein kinase inhibitors
Protein kinase inhibitors are a vital subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that play a crucial role in targeted cancer therapies. These inhibitors specifically target and block the activity of protein kinases, enzymes that regulate various cellular processes, including cell growth, division, and signal transduction.
Protein kinase inhibitors function by binding to the active site of protein kinases, preventing them from phosphorylating specific proteins and disrupting intracellular signaling pathways. This targeted approach inhibits the uncontrolled growth and proliferation of cancer cells, ultimately leading to their death.
The development of protein kinase inhibitors has revolutionized cancer treatment by providing more effective and less toxic alternatives to traditional chemotherapy. These drugs have demonstrated impressive results in the treatment of various cancers, including lung, breast, and leukemia.
The pharmaceutical industry invests heavily in research and development to discover novel protein kinase inhibitors with improved potency, selectivity, and pharmacokinetic properties. High-throughput screening, computational modeling, and structure-activity relationship studies are employed to identify potential lead compounds.
The success of protein kinase inhibitors in treating cancer has spurred significant interest in this subcategory of APIs. Ongoing research aims to expand their applications to other diseases, such as autoimmune disorders and neurological conditions.
In conclusion, protein kinase inhibitors are a valuable class of pharmaceutical APIs with immense potential for targeted cancer therapies. Continued advancements in this field hold promise for improved treatment outcomes and enhanced patient care.
Osimertinib (Protein kinase inhibitors), classified under Anticancer drugs
Anticancer drugs belong to the pharmaceutical API (Active Pharmaceutical Ingredient) category designed specifically to combat cancer cells. These powerful medications play a crucial role in cancer treatment and are developed to target and destroy cancerous cells, preventing their growth and spread.
Anticancer drugs are classified based on their mode of action and can include various types such as chemotherapy drugs, targeted therapy drugs, immunotherapy drugs, and hormonal therapy drugs. Chemotherapy drugs work by interfering with the cell division process, thereby inhibiting the growth of cancer cells. Targeted therapy drugs, on the other hand, are designed to attack specific molecules or genes involved in cancer growth, minimizing damage to healthy cells. Immunotherapy drugs stimulate the body's immune system to recognize and destroy cancer cells. Hormonal therapy drugs are used in cancers that are hormone-dependent, such as breast or prostate cancer, to block the hormones that fuel cancer cell growth.
These APIs are typically synthesized through complex chemical processes in state-of-the-art manufacturing facilities. Stringent quality control measures ensure the purity, potency, and safety of these drugs. Anticancer APIs undergo rigorous testing and adhere to stringent regulatory guidelines before being approved for clinical use.
Due to their critical role in cancer treatment, anticancer drugs are in high demand worldwide. Researchers and pharmaceutical companies continually strive to develop new and more effective APIs in this category to enhance treatment outcomes and minimize side effects. The ongoing advancements in the field of anticancer drug development offer hope for improved cancer therapies and better patient outcomes.
Osimertinib manufacturers | traders | suppliers
We have 8 companies offering Osimertinib produced in 3 different countries.
Get in contact with the supplier of your choice:
- Tianjin Pharmacn Medical Technology Co., ltd from China, product country of origin China
- Sichuan Elixir Pharmaceutical Co., Ltd from China, product country of origin China
- SETV Global from India, product country of origin India
- Apino Pharma Co., Ltd. from China, product country of origin China
- Shandong Octagon Chemicals Limited from China, product country of origin China
- R&S Chemicals from United States, product country of origin United States
- Shandong Boyuan from China, product country of origin China
- MSN Labs. from India, product country of origin India
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