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What makes Repaglinide unique? Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal.
Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Repaglinide is extensively metabolized in the liver and excreted in bile. Repaglinide metabolites do not possess appreciable hypoglycemic activity. Approximately 90% of a single orally administered dose is eliminated in feces and 8% in urine.
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Repaglinide manufacturers | traders | suppliers
We have 17 companies offering Repaglinide from 5 different countries.
Get in contact with the supplier of your choice:
- TIEFENBACHER API + Ingredients from Germany
- Aurobindo from India
- Sun Pharma from India
- Zhejiang Hisoar from China
- Biocon from India
- Polpharma from Poland
- Dr. Reddy's from India
- Flavine from Germany
- Jubilant Generics from India
- Macleods Pharma from India
- Torrent Pharma from India
- USV from India
- Chromo Labs. from India
- Actavis Group from Iceland
- Asymchem from China
- Themis Medicare from India
- Sichuan Benepure from China
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