Rolofylline API Manufacturers
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Looking for Rolofylline API 136199-02-5?
- Description:
- Here you will find a list of producers, manufacturers and distributors of Rolofylline. You can filter on certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
- API | Excipient name:
- Rolofylline
- Synonyms:
- Cas Number:
- 136199-02-5
- DrugBank number:
- DB12670
- Unique Ingredient Identifier:
- 7805S5HIHX
General Description:
Rolofylline, identified by CAS number 136199-02-5, is a notable compound with significant therapeutic applications. Rolofylline is under clinical development by pharmaceutical company NovaCardia for the treatment of congestive heart failure.
Mechanism of Action:
Rolofylline functions by: Rolofylline is an adenosine A1-receptor antagonist. Plasma adenosine levels are elevated in patients with heart failure and adenosine A1 receptors in the kidney mediate vasoconstriction of afferent arterioles, reabsorption of sodium and water in proximal tubules, and tubuloglomerular feedback in the juxtaglomerular apparatus. Accordingly, inhibition of these receptors would be expected to increase renal blood flow and enhance diuresis. The effects of Rolofylline on renal function are consistent with those obtained with another adenosine A1-receptor antagonist in both experimental and human heart failure. This mechanism highlights the drug's role in inhibiting or promoting specific biological pathways, contributing to its therapeutic effects.
Classification:
Rolofylline belongs to the class of organic compounds known as xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety, classified under the direct parent group Xanthines. This compound is a part of the Organic compounds, falling under the Organoheterocyclic compounds superclass, and categorized within the Imidazopyrimidines class, specifically within the Purines and purine derivatives subclass.
Categories:
Rolofylline is categorized under the following therapeutic classes: Alkaloids, Diuretics, Heterocyclic Compounds, Fused-Ring, Natriuretic Agents, Purines, Purinones. These classifications highlight the drug's diverse therapeutic applications and its importance in treating various conditions.
