Sildenafil API Manufacturers

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Located in:

India

Supply to over 40 countries around the globe

Contract manufacturing (CRAMS) services

High quality product & superior client service

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

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Produced in:

China

Established in: 2011

MOQ: 1 kg

Employees: 10+

Fast Response and Good Communication

Willingness To Start From Small

Flexible Payment Terms

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  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • CoA

  • MSDS

  • BSE/TSE

  • DMF

  • GMP

  • ISO9001

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Distributor

Produced in:

World

Established in: 2005

MOQ: -

Employees: 200+

Portfolio of over 2,000 APIs

Precise quality control

End-to-end global regulatory support

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

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  • BSE/TSE

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Produced in:

Unknown

Established in: 1923

MOQ: 25 kg

Employees: 20+

Service-oriented company

Global supply chain resilience

Support of your new projects from start to commercial realisation

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

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  • MSDS

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Producer

Produced in:

Unknown

Established in: 1944

MOQ: -

Employees: 4,000

14 international API plant sites

Portfolio of 350+ APIs

Teva is among the world’s largest generic drug/API manufacturers

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  • FDA

  • DMF

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Located in:

Mexico

Producer

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  • FDA

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  • CoA

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Replies slower than most

Located in:

India

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

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  • DMF

  • CoA

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Replies slower than most

Located in:

Slovenia

Producer

  • CoA

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  • FDA

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  • + 0

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  • GMP

  • CoA

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Replies slower than most

Located in:

India
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  • FDA

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  • DMF

  • CoA

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Replies slower than most

Located in:

India
  • CoA

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  • FDA

  • DMF

  • + 0

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  • CoA

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Replies slower than most

Located in:

India
  • CoA

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  • CEP

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  • DMF

  • + 0

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  • DMF

  • CoA

Located in:

India

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • WC

  • CoA

  • DMF

  • GMP

Located in:

India

Producer

  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

Located in:

India
  • CoA

  • GMP

  • CEP

  • FDA

  • DMF

  • + 0

All certificates

  • DMF

  • CoA

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Looking for Sildenafil API 139755-83-2?

Description:
Here you will find a list of producers, manufacturers and traders of Sildenafil. You can sort by certificates such as GMP, FDA, CEP, Written Confirmation and more. Send inquiries for free and get in direct contact with the supplier of your choice.
API | Excipient name:
Sildenafil 
Synonyms:
 
Cas Number:
139755-83-2 
DrugBank number:
DB00203 
Unique Ingredient Identifier:
3M7OB98Y7H

About Sildenafil

Some technical information about this product: In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart - before being serendipitously indicated for treating erectile dysfunction in the late 1980s.

You can find more info about this product by clicking on the DB ID above.



Sildenafil is a type of Phosphodiesterase-5 inhibitors


Phosphodiesterase-5 inhibitors are a subcategory of pharmaceutical active pharmaceutical ingredients (APIs) that are widely used in the treatment of various medical conditions. These inhibitors target the enzyme phosphodiesterase-5, which plays a crucial role in the regulation of cyclic guanosine monophosphate (cGMP) levels in the body.

By inhibiting phosphodiesterase-5, these APIs effectively increase the concentration of cGMP in certain tissues and organs, leading to several beneficial effects. One of the most well-known applications of phosphodiesterase-5 inhibitors is in the treatment of erectile dysfunction (ED). These medications, such as sildenafil, tadalafil, and vardenafil, work by enhancing the blood flow to the penile tissues, promoting and sustaining erections.

Phosphodiesterase-5 inhibitors also find applications in the treatment of pulmonary arterial hypertension (PAH). By dilating the blood vessels in the lungs, these APIs reduce the workload on the heart and improve exercise capacity in PAH patients. Furthermore, they are being explored for their potential benefits in other areas, such as the treatment of Raynaud's disease and altitude sickness.

It is important to note that phosphodiesterase-5 inhibitors should be used under medical supervision, as they can interact with other medications and have potential side effects. Common side effects include headache, flushing, nasal congestion, and gastrointestinal disturbances.

In summary, phosphodiesterase-5 inhibitors are a class of pharmaceutical APIs that are widely utilized for the treatment of erectile dysfunction and pulmonary arterial hypertension. Their ability to selectively inhibit phosphodiesterase-5 and modulate cGMP levels makes them valuable therapeutic agents in managing these conditions.


Sildenafil (Phosphodiesterase-5 inhibitors), classified under Genitourinary Agents


Genitourinary agents are a category of pharmaceutical active ingredients (APIs) that are specifically designed to target and treat disorders related to the genitourinary system. The genitourinary system encompasses the organs and structures involved in the production, storage, and elimination of urine, as well as the reproductive organs.

These APIs play a crucial role in the treatment of various genitourinary conditions, including urinary tract infections (UTIs), erectile dysfunction, urinary incontinence, benign prostatic hyperplasia (BPH), and other related disorders. They exert their therapeutic effects by interacting with specific receptors or enzymes in the genitourinary system, regulating physiological processes, and restoring normal function.

Some commonly used genitourinary agents include alpha-blockers, which relax the smooth muscles in the prostate and bladder neck, improving urine flow in patients with BPH. Additionally, phosphodiesterase type 5 inhibitors (PDE5 inhibitors) are widely prescribed for erectile dysfunction, as they enhance blood flow to the penile tissues, facilitating erection.

These APIs are typically formulated into various dosage forms, such as tablets, capsules, creams, gels, or injections, allowing for convenient administration to patients. The development and production of genitourinary agents involve stringent quality control measures and compliance with regulatory guidelines to ensure safety, efficacy, and consistent product performance.

In summary, genitourinary agents form a crucial category of pharmaceutical APIs used to treat a range of disorders affecting the genitourinary system. Their targeted mechanisms of action and diverse dosage forms make them valuable tools in improving genitourinary health and enhancing patients' quality of life.



Sildenafil manufacturers | traders | suppliers

We have 14 companies offering Sildenafil produced in 6 different countries.

Get in contact with the supplier of your choice:

  • Hari Ganesh Pharma Private Limited from India, product country of origin India
  • Shandong Octagon Chemicals Limited from China, product country of origin China
  • LGM Pharma from United States, product country of origin World
  • Otto Brandes GmbH from Germany, product country of origin Unknown
  • Teva API from Israel, product country of origin Unknown
  • Signa from Mexico, product country of origin Mexico
  • Raks Pharma from India, product country of origin India
  • KRKA from Slovenia, product country of origin Slovenia
  • Torrent Pharma from India, product country of origin India
  • Amoli Organics from India, product country of origin India
  • Hetero Drugs from India, product country of origin India
  • Mylan from India, product country of origin India
  • Aurobindo from India, product country of origin India
  • MSN Organics from India, product country of origin India

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